Pituitary disease and recovery: How are stem cells involved?
Ageing
Injury
Pituitary
Regeneration
Stem cells
Tumour
Journal
Molecular and cellular endocrinology
ISSN: 1872-8057
Titre abrégé: Mol Cell Endocrinol
Pays: Ireland
ID NLM: 7500844
Informations de publication
Date de publication:
05 04 2021
05 04 2021
Historique:
received:
12
06
2020
revised:
13
01
2021
accepted:
19
01
2021
pubmed:
28
1
2021
medline:
7
10
2021
entrez:
27
1
2021
Statut:
ppublish
Résumé
The pituitary gland embodies our endocrine hub and rigorously regulates hormone balances in the body, thereby ruling over vital developmental and physiological processes. Pituitary dysfunction and disease strongly impact the organism's biology. Physical damage, tumour development and ageing all negatively affect pituitary state and functionality. On top of its hormone-producing cells, the pituitary contains a population of stem cells. Not only their physiological role is still largely unknown, also whether or how these stem cells are involved in pituitary disease and recovery from defective functionality remains enigmatic. Here, we summarize what is known on the phenotypical and functional behaviour of pituitary stem cells in diseased or dysfunctional gland, as particularly caused by injury, tumourigenesis and ageing.
Identifiants
pubmed: 33503464
pii: S0303-7207(21)00020-4
doi: 10.1016/j.mce.2021.111176
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
111176Informations de copyright
Copyright © 2021 Elsevier B.V. All rights reserved.