Donor Preconditioning with Inhaled Sevoflurane Mitigates the Effects of Ischemia-Reperfusion Injury in a Swine Model of Lung Transplantation.
Administration, Inhalation
Anesthetics, Inhalation
/ administration & dosage
Animals
Disease Models, Animal
Ischemic Preconditioning
/ methods
Lung
/ drug effects
Lung Transplantation
/ methods
Reperfusion Injury
/ metabolism
Sevoflurane
/ administration & dosage
Sus scrofa
Swine
Transplants
/ drug effects
Journal
BioMed research international
ISSN: 2314-6141
Titre abrégé: Biomed Res Int
Pays: United States
ID NLM: 101600173
Informations de publication
Date de publication:
2021
2021
Historique:
received:
02
11
2020
revised:
18
12
2020
accepted:
28
12
2020
entrez:
28
1
2021
pubmed:
29
1
2021
medline:
29
5
2021
Statut:
epublish
Résumé
Primary graft dysfunction (PGD) and ischemia-reperfusion injury (IRI) occur in up to 30% of patients undergoing lung transplantation and may impact on the clinical outcome. Several strategies for the prevention and treatment of PGD have been proposed, but with limited use in clinical practice. In this study, we investigate the potential application of sevoflurane (SEV) preconditioning to mitigate IRI after lung transplantation. The study included two groups of swines (preconditioned and not preconditioned with SEV) undergoing left lung transplantation after 24-hour of cold ischemia. Recipients' data was collected for 6 hours after reperfusion. Outcome analysis included assessment of ventilatory, hemodynamic, and hemogasanalytic parameters, evaluation of cellularity and cytokines in BAL samples, and histological analysis of tissue samples. Hemogasanalytic, hemodynamic, and respiratory parameters were significantly favorable, and the histological score showed less inflammatory and fibrotic injury in animals receiving SEV treatment. BAL cellular and cytokine profiling showed an anti-inflammatory pattern in animals receiving SEV compared to controls. In a swine model of lung transplantation after prolonged cold ischemia, SEV showed to mitigate the adverse effects of ischemia/reperfusion and to improve animal survival. Given the low cost and easy applicability, the administration of SEV in lung donors may be more extensively explored in clinical practice.
Identifiants
pubmed: 33506025
doi: 10.1155/2021/6625955
pmc: PMC7815409
doi:
Substances chimiques
Anesthetics, Inhalation
0
Sevoflurane
38LVP0K73A
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
6625955Informations de copyright
Copyright © 2021 Alessandro Bertani et al.
Déclaration de conflit d'intérêts
The authors declare that they have no conflicts of interest.
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