Spatial Association between Gastric Cancer Mortality and Goiter in Sardinia.
Diet
Goiter
Helicobacter pylori
gastric carcinoma
stature
Journal
Asian Pacific journal of cancer prevention : APJCP
ISSN: 2476-762X
Titre abrégé: Asian Pac J Cancer Prev
Pays: Thailand
ID NLM: 101130625
Informations de publication
Date de publication:
01 Jan 2021
01 Jan 2021
Historique:
received:
14
08
2020
entrez:
28
1
2021
pubmed:
29
1
2021
medline:
5
10
2021
Statut:
epublish
Résumé
Gastric cancer (GC) is the third leading cause of cancer mortality worldwide. The incidence of GC varies between countries according to exposure to different risk factors. Hypothyroidism has been suggested as a potential GC risk factor. In Sardinia, Italy, the prevalence of endemic goiter is high and GC mortality is unevenly distributed. This ecological study aimed to investigate GC mortality and its relationship with hypothyroidism, adjusting for potential confounders. The spatial association between GC mortality and goiter (a proxy of hypothyroidism), diet, stature and pastoralism (a proxy of Helicobacter pylori infection), available at the aggregated level, was modelled in the island's 377 municipalities, separately by sex, using geographically weighted regression (GWR). The GC standardized mortality ratio ranged from 0.0 to 10.4 across municipalities. A hotspot of GC mortality was detected in the central mountainous area of Sardinia among males, positively associated with goiter (GWR estimate 0.213 ± 0.122), and the practice of sheep‒rearing (GWR estimate 0.127 ± 0.080), whereas a negative association with the diet score (GWR estimate 0.032 ± 0.034), and null for stature were found. No significant associations were found in females. Within the limitations of ecological studies goiter prevalence was an independent predictor of GC mortality in males.
Sections du résumé
BACKGROUND
BACKGROUND
Gastric cancer (GC) is the third leading cause of cancer mortality worldwide. The incidence of GC varies between countries according to exposure to different risk factors. Hypothyroidism has been suggested as a potential GC risk factor. In Sardinia, Italy, the prevalence of endemic goiter is high and GC mortality is unevenly distributed. This ecological study aimed to investigate GC mortality and its relationship with hypothyroidism, adjusting for potential confounders.
METHODS
METHODS
The spatial association between GC mortality and goiter (a proxy of hypothyroidism), diet, stature and pastoralism (a proxy of Helicobacter pylori infection), available at the aggregated level, was modelled in the island's 377 municipalities, separately by sex, using geographically weighted regression (GWR).
RESULTS
RESULTS
The GC standardized mortality ratio ranged from 0.0 to 10.4 across municipalities. A hotspot of GC mortality was detected in the central mountainous area of Sardinia among males, positively associated with goiter (GWR estimate 0.213 ± 0.122), and the practice of sheep‒rearing (GWR estimate 0.127 ± 0.080), whereas a negative association with the diet score (GWR estimate 0.032 ± 0.034), and null for stature were found. No significant associations were found in females.
CONCLUSION
CONCLUSIONS
Within the limitations of ecological studies goiter prevalence was an independent predictor of GC mortality in males.
Identifiants
pubmed: 33507686
doi: 10.31557/APJCP.2021.22.1.105
pmc: PMC8184186
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
105-110Références
Isr J Med Sci. 1985 Oct;21(10):864
pubmed: 4077481
Lancet. 1999 Jul 10;354(9173):132
pubmed: 10408497
Cancer Epidemiol Biomarkers Prev. 1996 Sep;5(9):673-7
pubmed: 8877056
Int J Cancer. 1987 Oct 15;40(4):484-9
pubmed: 3117710
Stat Med. 2005 Sep 15;24(17):2695-717
pubmed: 16118814
Proc Nutr Soc. 2008 Aug;67(3):253-6
pubmed: 18452640
Eur J Nutr. 2007 Aug;46(5):251-6
pubmed: 17497074
Am J Gastroenterol. 2001 May;96(5):1396-401
pubmed: 11374673
Eur J Med Res. 2017 Jun 21;22(1):21
pubmed: 28637498
Panminerva Med. 2016 Dec;58(4):304-317
pubmed: 27716738
Lancet Oncol. 2015 Dec;16(16):1599-600
pubmed: 26514947
Gastric Cancer. 2014;17(3):463-8
pubmed: 24174008
Eur J Ageing. 2019 Mar 22;16(4):405-414
pubmed: 31798366
Nutr Metab Cardiovasc Dis. 2013 Mar;23(3):212-9
pubmed: 21958760
Dig Dis Sci. 2011 May;56(5):1585-6; author reply 1586
pubmed: 21394461
Lancet. 2018 Nov 10;392(10159):1736-1788
pubmed: 30496103
Br J Cancer. 1954 Sep;8(3):393-411
pubmed: 13230371
Cancers (Basel). 2019 Apr 28;11(5):
pubmed: 31035365
Adv Clin Path. 2000 Jan;4(1):11-7
pubmed: 10936894
J Dairy Sci. 2009 Oct;92(10):5133-8
pubmed: 19762831
Eur J Endocrinol. 1999 Apr;140(4):371-2
pubmed: 10097259
Am J Clin Nutr. 2003 Sep;78(3 Suppl):559S-569S
pubmed: 12936950
Eur J Clin Nutr. 2015 Apr;69(4):411-8
pubmed: 25369832
Cancer Lett. 2002 Jan 25;175(2):121-7
pubmed: 11741739
Int J Cancer. 2006 Sep 15;119(6):1508-10
pubmed: 16642482
Int J Cancer. 2006 Jul 1;119(1):196-201
pubmed: 16450397
Gastric Cancer. 2007;10(2):75-83
pubmed: 17577615
Am J Lifestyle Med. 2016 Jul 07;10(5):318-321
pubmed: 30202288
Asian Pac J Cancer Prev. ;18(9):2403-2407
pubmed: 28950694
Endocr Metab Immune Disord Drug Targets. 2017;17(1):56-62
pubmed: 28322173
Best Pract Res Clin Gastroenterol. 2006;20(4):633-49
pubmed: 16997150
J Clin Med. 2020 Jan 03;9(1):
pubmed: 31947827
Am J Phys Anthropol. 2017 May;163(1):3-13
pubmed: 28138956
Bull World Health Organ. 1960;22:493-502
pubmed: 13849448
Int J Cancer. 1997 Mar 28;71(1):14-9
pubmed: 9096659
Biometrika. 1950 Jun;37(1-2):17-23
pubmed: 15420245
Thyroid. 2001 Sep;11(9):849-57
pubmed: 11575854
Arch Environ Health. 1994 Mar-Apr;49(2):119-22
pubmed: 8161241
Eur J Cancer. 2008 Nov;44(16):2397-403
pubmed: 18755583
Front Oncol. 2018 Aug 23;8:326
pubmed: 30191141
Eur J Cancer Prev. 1993 Jan;2(1):17-23
pubmed: 8428171
J Clin Med. 2019 May 30;8(6):
pubmed: 31151171
Dig Dis Sci. 1999 Jun;44(6):1161-4
pubmed: 10389689
Stat Med. 1995 Apr 30;14(8):799-810
pubmed: 7644860
Int J Endocrinol. 2017;2017:8401518
pubmed: 28356911
Br J Cancer. 1993 Sep;68(3):515-8
pubmed: 8353042