Ulmusakidian, a new coumarin glycoside and antifungal phenolic compounds from the root bark of Ulmus davidiana var. japonica.
Antifungal Agents
/ chemistry
Candida albicans
/ drug effects
Cryptococcus neoformans
/ drug effects
Dose-Response Relationship, Drug
Microbial Sensitivity Tests
Molecular Structure
Phenols
/ chemistry
Plant Extracts
/ chemistry
Plant Roots
/ chemistry
Structure-Activity Relationship
Ulmus
/ chemistry
Antifungal activity
Coumarin glycoside
Ulmaceae
Ulmus davidiana var. japonica
Journal
Bioorganic & medicinal chemistry letters
ISSN: 1464-3405
Titre abrégé: Bioorg Med Chem Lett
Pays: England
ID NLM: 9107377
Informations de publication
Date de publication:
15 03 2021
15 03 2021
Historique:
received:
30
10
2020
revised:
30
12
2020
accepted:
19
01
2021
pubmed:
29
1
2021
medline:
30
7
2021
entrez:
28
1
2021
Statut:
ppublish
Résumé
Bioactivity-driven LC/MS-based phytochemical analysis of the root bark extract of Ulmus davidiana var. japonica led to the isolation of 10 compounds including a new coumarin glycoside derivative, ulmusakidian (1). The structure of the new compound was elucidated using extensive spectroscopic analyses via 1D and 2D NMR spectroscopic data interpretations, HR-ESIMS, and chemical transformation. The isolated compounds 1-10 were tested for their antifungal activity against human fungal pathogens Cryptococcus neoformans and Candida albicans. Compounds 9 and 10 showed antifungal activity against C. neoformans, with the lowest minimal inhibitory concentration (MIC) of 12.5-25.0 µg/mL, whereas none of the compounds showed antifungal activity against C. albicans.
Identifiants
pubmed: 33508466
pii: S0960-894X(21)00054-8
doi: 10.1016/j.bmcl.2021.127828
pii:
doi:
Substances chimiques
Antifungal Agents
0
Phenols
0
Plant Extracts
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
127828Informations de copyright
Copyright © 2021 Elsevier Ltd. All rights reserved.