Evaluation of drug-induced liver injury as etiology for acute liver failure in Brazil.
Acute liver failure
Drug induced liver injury
Liver injury
Journal
Annals of hepatology
ISSN: 1665-2681
Titre abrégé: Ann Hepatol
Pays: Mexico
ID NLM: 101155885
Informations de publication
Date de publication:
Historique:
received:
15
10
2020
revised:
10
12
2020
accepted:
11
12
2020
pubmed:
29
1
2021
medline:
14
1
2022
entrez:
28
1
2021
Statut:
ppublish
Résumé
Little is known about the etiology of acute liver failure (ALF) in Latin America. The objective of this paper is to investigate the main etiologies of ALF in Brazil, including Drug Induced Liver Injury (DILI) using stringent causality criteria. All the cases of individuals who underwent liver transplantation (LT) in 12 centers in Brazil for ALF were reviewed. When DILI was stated as the cause of ALF, causality criteria were applied on site by the main investigator in order to rule out other etiologies. 325 individuals had ALF mainly for unknown reasons (34%), DILI (27%) and AIH (18%). Reassessment of the 89 cases of DILI, using stringent causality criteria, revealed that in only 42 subjects could DILI be confirmed as the cause of ALF. Acetaminophen (APAP) toxicity (n = 3) or DILI due to herbal and dietary supplements (HDS) (n = 2) were not commonly observed. Undetermined etiology and DILI are the main causes of ALF in Brazil. However, APAP toxicity and DILI due to HDS are mostly uncommon.
Identifiants
pubmed: 33508520
pii: S1665-2681(21)00009-0
doi: 10.1016/j.aohep.2021.100310
pii:
doi:
Substances chimiques
Acetaminophen
362O9ITL9D
Types de publication
Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
100310Informations de copyright
Copyright © 2021. Published by Elsevier España, S.L.U.