A Phase 1 and Biodistribution Study of ABT-806i, an

Adult Antibodies, Monoclonal, Humanized / immunology Cohort Studies ErbB Receptors / immunology Female Glioblastoma / diagnostic imaging Humans Immunoconjugates / immunology Indium Radioisotopes Isotope Labeling Male Middle Aged Tissue Distribution Tomography, Emission-Computed, Single-Photon
EGFR EGFRvIII SPECT imaging biodistribution solid tumors

Journal

Journal of nuclear medicine : official publication, Society of Nuclear Medicine
ISSN: 1535-5667
Titre abrégé: J Nucl Med
Pays: United States
ID NLM: 0217410

Informations de publication

Date de publication:
01 06 2021
Historique:
received: 08 07 2020
accepted: 16 09 2020
pubmed: 30 1 2021
medline: 27 8 2021
entrez: 29 1 2021
Statut: ppublish

Résumé

ABT-806 is a tumor-specific antibody targeting the epidermal growth factor receptor (EGFR). This study assessed safety, biodistribution, and pharmacokinetics of

Identifiants

DOI: 10.2967/jnumed.120.253146 PMID: 33509972
pubmed: 33509972
pii: jnumed.120.253146
doi: 10.2967/jnumed.120.253146
doi:

Substances chimiques

Antibodies, Monoclonal, Humanized 0
Immunoconjugates 0
Indium Radioisotopes 0
Indium-111 E9NGC49E0T
ErbB Receptors EC 2.7.10.1
depatuxizumab W984C353CG

Banques de données

ClinicalTrials.gov
['NCT01472003']

Types de publication

Clinical Trial, Phase I Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

787-794

Informations de copyright

© 2021 by the Society of Nuclear Medicine and Molecular Imaging.

Auteurs

Hui K Gan (HK)

Olivia Newton-John Cancer Research Institute, Austin Health, Melbourne, Australia hui.gan@onjcri.org.au.
School of Cancer Medicine, La Trobe University, Melbourne, Australia.
Department of Medicine, University of Melbourne, Melbourne, Australia.

Matthew Burge (M)

Royal Brisbane and Women's Hospital, Brisbane, Australia.
University of Queensland, Brisbane, Australia.

Benjamin Solomon (B)

Department of Medicine, University of Melbourne, Melbourne, Australia.
Peter MacCallum Cancer Centre, Melbourne, Australia.

Sze Ting Lee (ST)

Olivia Newton-John Cancer Research Institute, Austin Health, Melbourne, Australia.
School of Cancer Medicine, La Trobe University, Melbourne, Australia.
Department of Molecular Imaging and Therapy, Austin Health, Melbourne, Australia.

Kyle D Holen (KD)

AbbVie, North Chicago, Illinois; and.

Yumin Zhang (Y)

Sinotau Pharmaceutical Group, Beijing, China.

Marika Ciprotti (M)

Olivia Newton-John Cancer Research Institute, Austin Health, Melbourne, Australia.

F T Lee (FT)

Olivia Newton-John Cancer Research Institute, Austin Health, Melbourne, Australia.

Wijith Munasinghe (W)

AbbVie, North Chicago, Illinois; and.

JuDee Fischer (J)

AbbVie, North Chicago, Illinois; and.

Peter Ansell (P)

AbbVie, North Chicago, Illinois; and.

Gerard Fox (G)

AbbVie, North Chicago, Illinois; and.

Hao Xiong (H)

AbbVie, North Chicago, Illinois; and.

Edward B Reilly (EB)

AbbVie, North Chicago, Illinois; and.

Rod Humerickhouse (R)

AbbVie, North Chicago, Illinois; and.

Andrew M Scott (AM)

Olivia Newton-John Cancer Research Institute, Austin Health, Melbourne, Australia.
School of Cancer Medicine, La Trobe University, Melbourne, Australia.
Department of Medicine, University of Melbourne, Melbourne, Australia.
Department of Molecular Imaging and Therapy, Austin Health, Melbourne, Australia.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › A Phase 1 and Biodistribution Study of ABT-806i, an
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Anticorps › Anticorps monoclonaux › Anticorps monoclonaux humanisés › A Phase 1 and Biodistribution Study of ABT-806i, an
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › A Phase 1 and Biodistribution Study of ABT-806i, an
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs peptidiques › Récepteur facteur croissance › Récepteurs ErbB › A Phase 1 and Biodistribution Study of ABT-806i, an
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Tumeurs du tissu nerveux › Tumeurs neuroectodermiques › Tumeurs neuroépitheliales › Gliome › Astrocytome › Glioblastome › A Phase 1 and Biodistribution Study of ABT-806i, an
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › A Phase 1 and Biodistribution Study of ABT-806i, an
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Facteurs immunologiques › Immunoconjugués › A Phase 1 and Biodistribution Study of ABT-806i, an
questionsmedicales.fr › Produits chimiques inorganiques › Isotopes › Radio-isotopes › Radio-isotopes de l'indium › A Phase 1 and Biodistribution Study of ABT-806i, an
questionsmedicales.fr › Techniques d'investigation › Marquage isotopique › A Phase 1 and Biodistribution Study of ABT-806i, an
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › A Phase 1 and Biodistribution Study of ABT-806i, an
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Pharmacocinétique › Distribution tissulaire › A Phase 1 and Biodistribution Study of ABT-806i, an
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Techniques de diagnostic radioisotopique › Scintigraphie › Tomoscintigraphie › Tomographie par émission monophotonique › A Phase 1 and Biodistribution Study of ABT-806i, an