Genome-wide meta-analysis of muscle weakness identifies 15 susceptibility loci in older men and women.

Aged Aged, 80 and over Aging / genetics Cohort Studies Europe Female Genetic Predisposition to Disease / genetics Genome-Wide Association Study / methods Growth Differentiation Factor 5 / genetics HLA-DQ alpha-Chains / genetics Humans Male Middle Aged Muscle Strength / genetics Muscle Weakness / genetics Polymorphism, Single Nucleotide Sarcopenia / genetics

Journal

Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555

Informations de publication

Date de publication:
28 01 2021
Historique:
received: 13 05 2020
accepted: 22 12 2020
entrez: 29 1 2021
pubmed: 30 1 2021
medline: 23 2 2021
Statut: epublish

Résumé

Low muscle strength is an important heritable indicator of poor health linked to morbidity and mortality in older people. In a genome-wide association study meta-analysis of 256,523 Europeans aged 60 years and over from 22 cohorts we identify 15 loci associated with muscle weakness (European Working Group on Sarcopenia in Older People definition: n = 48,596 cases, 18.9% of total), including 12 loci not implicated in previous analyses of continuous measures of grip strength. Loci include genes reportedly involved in autoimmune disease (HLA-DQA1 p = 4 × 10

Identifiants

DOI: 10.1038/s41467-021-20918-w PMID: 33510174 PMC: PMC7844411
pubmed: 33510174
doi: 10.1038/s41467-021-20918-w
pii: 10.1038/s41467-021-20918-w
pmc: PMC7844411
doi:

Substances chimiques

GDF5 protein, human 0
Growth Differentiation Factor 5 0
HLA-DQ alpha-Chains 0
HLA-DQA1 antigen 0

Types de publication

Journal Article Meta-Analysis Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

654

Subventions

Organisme : Medical Research Council
ID : MC_UU_00006/1
Pays : United Kingdom
Organisme : NHLBI NIH HHS
ID : R01 HL120393
Pays : United States
Organisme : NHLBI NIH HHS
ID : U01 HL130114
Pays : United States
Organisme : Medical Research Council
ID : MC_UU_12015/1
Pays : United Kingdom
Organisme : NHLBI NIH HHS
ID : U01 HL120393
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG017917
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL105756
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG010161
Pays : United States
Organisme : NIA NIH HHS
ID : U19 AG063893
Pays : United States
Organisme : Medical Research Council
ID : MR/M008924/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/M023095/1
Pays : United Kingdom
Organisme : NIA NIH HHS
ID : K01 AG057726
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG015819
Pays : United States

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Auteurs

Garan Jones (G)

Epidemiology and Public Health Group, Institute of Biomedical and Clinical Science, University of Exeter Medical School, Exeter, UK.
ORCID: 0000-0002-8917-3930

Katerina Trajanoska (K)

Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands.
Department of Epidemiology Medicine, Erasmus Medical Center, Rotterdam, The Netherlands.
ORCID: 0000-0002-3792-4296

Adam J Santanasto (AJ)

University of Pittsburgh, Department of Epidemiology, Pittsburgh, PA, USA.
ORCID: 0000-0002-6912-2909

Najada Stringa (N)

Department of Epidemiology and Biostatistics, Amsterdam UMC- Vrije Universiteit, Amsterdam Public Health Research Institute, Amsterdam, The Netherlands.
ORCID: 0000-0001-6350-452X

Chia-Ling Kuo (CL)

Biostatistics Center, Connecticut Convergence Institute for Translation in Regenerative Engineering, UConn Health, Farmington, CT, USA.

Janice L Atkins (JL)

Epidemiology and Public Health Group, Institute of Biomedical and Clinical Science, University of Exeter Medical School, Exeter, UK.
ORCID: 0000-0003-4919-9068

Joshua R Lewis (JR)

School of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, Australia.
School fo Public Health University of Sydney, Sydney, NSW, Australia.
Medical School, University of Western Australia, Crawley, WA, Australia.
ORCID: 0000-0003-1003-8443

ThuyVy Duong (T)

McKusick-Nathans Institute, Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Shengjun Hong (S)

Lübeck Interdisciplinary Plattform for Genome Analytics, Institutes of Neurogenetics and Cardiogenetics, University of Lübeck, Lübeck, Germany.

Mary L Biggs (ML)

Cardiovascular Health Research Unit, Department of Medicine, and Department of Biostatistics, University of Washington, Seattle, WA, USA.

Jian'an Luan (J)

MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge, CB2 0QQ, UK.
ORCID: 0000-0003-3137-6337

Chloe Sarnowski (C)

Biostatistics Department, Boston University School of Public Health, Boston, MA, USA.
ORCID: 0000-0002-6090-7099

Kathryn L Lunetta (KL)

Biostatistics Department, Boston University School of Public Health, Boston, MA, USA.
ORCID: 0000-0002-9268-810X

Toshiko Tanaka (T)

Longitudinal Study Section, Translational Gerontology branch, National Institute on Aging, Baltimore, MD, USA.

Mary K Wojczynski (MK)

Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA.

Ryan Cvejkus (R)

University of Pittsburgh, Department of Epidemiology, Pittsburgh, PA, USA.
ORCID: 0000-0001-5287-5341

Maria Nethander (M)

Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Bioinformatics Core Facility, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
ORCID: 0000-0003-3688-906X

Sahar Ghasemi (S)

Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany.
Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.

Jingyun Yang (J)

Rush Alzheimer's Disease Center & Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA.
ORCID: 0000-0002-3495-3710

M Carola Zillikens (MC)

Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands.

Stefan Walter (S)

Department of Medicine and Public Health, Rey Juan Carlos University, Madrid, Spain.
CIBER of Frailty and Healthy Aging (CIBERFES), Madrid, Spain.
ORCID: 0000-0002-6010-7550

Kamil Sicinski (K)

Center for Demography of Health and Aging, University of Wisconsin-Madison, Madison, WI, USA.

Erika Kague (E)

School of Physiology, Pharmacology and Neuroscience, University of Bristol, Bristol, UK.
ORCID: 0000-0002-0266-9424

Cheryl L Ackert-Bicknell (CL)

Department of Orthopedics, University of Colorado, Aurora, CO, USA.

Dan E Arking (DE)

McKusick-Nathans Institute, Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

B Gwen Windham (BG)

Department of Medicine/Geriatrics, University of Mississippi School of Medicine, Jackson, MS, USA.

Eric Boerwinkle (E)

Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA.

Megan L Grove (ML)

Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.

Misa Graff (M)

Department of Epidemiology, University of North Carolina, Chapel Hill, NC, 27516, USA.
ORCID: 0000-0001-6380-1735

Dominik Spira (D)

Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.
Berlin Institute of Health, Department of Endocrinology and Metabolism, Berlin, Germany.

Ilja Demuth (I)

Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.
Berlin Institute of Health, Department of Endocrinology and Metabolism, Berlin, Germany.
Charité - Universitätsmedizin Berlin, BCRT - Berlin Institute of Health Center for Regenerative Therapies, Berlin, Germany.

Nathalie van der Velde (N)

Department of Internal Medicine, Section of Geriatric Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

Lisette C P G M de Groot (LCPGM)

Wageningen University, Division of Human Nutrition, PO-box 17, 6700 AA, Wageningen, The Netherlands.
ORCID: 0000-0003-2778-2789

Bruce M Psaty (BM)

Cardiovascular Health Research Unit, Departments of Medicine, Epidemiology, and Health services, University of Washington, Seattle, WA, USA.
Kaiser Permanente Washington Health Research Institute, Seattle, WA, USA.

Michelle C Odden (MC)

Department of Epidemiology and Population Health, Stanford University, Stanford, CA, USA.

Alison E Fohner (AE)

Department of Epidemiology and Institute of Public Genetics, University of Washington, Seattle, WA, USA.

Claudia Langenberg (C)

MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge, CB2 0QQ, UK.
ORCID: 0000-0002-5017-7344

Nicholas J Wareham (NJ)

MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge, CB2 0QQ, UK.
ORCID: 0000-0003-1422-2993

Stefania Bandinelli (S)

Geriatric Unit, Azienda Sanitaria Firenze (ASF), Florence, Italy.

Natasja M van Schoor (NM)

Department of Epidemiology and Biostatistics, Amsterdam UMC- Vrije Universiteit, Amsterdam Public Health Research Institute, Amsterdam, The Netherlands.

Martijn Huisman (M)

Department of Epidemiology and Biostatistics, Amsterdam UMC- Vrije Universiteit, Amsterdam Public Health Research Institute, Amsterdam, The Netherlands.

Qihua Tan (Q)

Epidemiology and Biostatistics, Department of Public Health, Faculty of Health Science, University of Southern Denmark, Odense, Denmark.
ORCID: 0000-0003-3194-0030

Joseph Zmuda (J)

University of Pittsburgh, Department of Epidemiology, Pittsburgh, PA, USA.

Dan Mellström (D)

Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Geriatric Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

Magnus Karlsson (M)

Clinical and Molecular Osteoporosis Research Unit, Department of Orthopedics and Clinical Sciences, Lund University, Skåne University Hospital, Malmö, Sweden.

David A Bennett (DA)

Rush Alzheimer's Disease Center & Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA.

Aron S Buchman (AS)

Rush Alzheimer's Disease Center & Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA.
ORCID: 0000-0002-6426-2742

Philip L De Jager (PL)

Center for Translational and Systems Neuroimmunology, Department of Neurology, Columbia University Medical Center, New York, NY, USA.
Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA.
ORCID: 0000-0002-8057-2505

Andre G Uitterlinden (AG)

Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands.
ORCID: 0000-0002-7276-3387

Uwe Völker (U)

Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany.
ORCID: 0000-0002-5689-3448

Thomas Kocher (T)

Department of Restorative Dentistry, Periodontology, Endodontology, and Preventive and Pediatric Dentistry, University Medicine Greifswald, Greifswald, Germany.
ORCID: 0000-0001-9605-2822

Alexander Teumer (A)

Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.
ORCID: 0000-0002-8309-094X

Leocadio Rodriguéz-Mañas (L)

CIBER of Frailty and Healthy Aging (CIBERFES), Madrid, Spain.
Department of Geriatrics, Getafe University Hospital, Getafe, Spain.

Francisco J García (FJ)

CIBER of Frailty and Healthy Aging (CIBERFES), Madrid, Spain.
Department of Geriatrics, Hospital Virgen del Valle, Complejo Hospitalario de Toledo, Toledo, Spain.

José A Carnicero (JA)

CIBER of Frailty and Healthy Aging (CIBERFES), Madrid, Spain.

Pamela Herd (P)

Professor of Public Policy, Georgetown University, Washington, DC, USA.

Lars Bertram (L)

Lübeck Interdisciplinary Plattform for Genome Analytics, Institutes of Neurogenetics and Cardiogenetics, University of Lübeck, Lübeck, Germany.
ORCID: 0000-0002-0108-124X

Claes Ohlsson (C)

Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Sahlgrenska University Hospital, Department of Drug Treatment, Gothenburg, Sweden.

Joanne M Murabito (JM)

Section of General Internal Medicine, Boston University School of Medicine, Boston, MA, USA.

David Melzer (D)

Epidemiology and Public Health Group, Institute of Biomedical and Clinical Science, University of Exeter Medical School, Exeter, UK.
ORCID: 0000-0002-0170-3838

George A Kuchel (GA)

Center on Aging, University of Connecticut Health, 263 Farmington Avenue, Farmington, CT, 06030, USA.
ORCID: 0000-0001-8387-7040

Luigi Ferrucci (L)

National Institute on Aging, Baltimore, MD, USA.
ORCID: 0000-0002-6273-1613

David Karasik (D)

Marcus Institute for Aging Research, Hebrew SeniorLife, Boston, MA, USA.
Azrieli Faculty of Medicine, Bar Ilan University, Safed, Israel.
ORCID: 0000-0002-8826-0530

Fernando Rivadeneira (F)

Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands.
Department of Epidemiology Medicine, Erasmus Medical Center, Rotterdam, The Netherlands.
ORCID: 0000-0001-9435-9441

Douglas P Kiel (DP)

Marcus Institute for Aging Research, Hebrew SeniorLife and Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Broad Institute of MIT & Harvard, Boston, MA, USA.
ORCID: 0000-0001-8474-0310

Luke C Pilling (LC)

Epidemiology and Public Health Group, Institute of Biomedical and Clinical Science, University of Exeter Medical School, Exeter, UK. L.Pilling@exeter.ac.uk.
ORCID: 0000-0002-3332-8454

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Genome-wide meta-analysis of muscle weakness...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Sujet âgé de 80 ans ou plus › Genome-wide meta-analysis of muscle weakness...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Vieillissement › Genome-wide meta-analysis of muscle weakness...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Genome-wide meta-analysis of muscle weakness...
questionsmedicales.fr › Régions géographiques › Europe › Genome-wide meta-analysis of muscle weakness...
questionsmedicales.fr › Phénomènes génétiques › Génotype › Prédisposition génétique à une maladie › Genome-wide meta-analysis of muscle weakness...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Épidémiologie moléculaire › Étude d'association pangénomique › Genome-wide meta-analysis of muscle weakness...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Protéines de la superfamille du TGF bêta › Facteurs de croissance et de différenciation › Facteur-5 de croissance et de différenciation › Genome-wide meta-analysis of muscle weakness...
questionsmedicales.fr › Facteurs biologiques › Antigènes › Isoantigènes › Antigènes d'histocompatibilité › Antigènes HLA › Antigènes HLA-D › Antigènes HLA-DQ › Chaines alpha des antigènes HLA-DQ › Genome-wide meta-analysis of muscle weakness...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Genome-wide meta-analysis of muscle weakness...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Genome-wide meta-analysis of muscle weakness...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système locomoteur › Force musculaire › Genome-wide meta-analysis of muscle weakness...
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Manifestations neurologiques › Manifestations neuromusculaires › Faiblesse musculaire › Genome-wide meta-analysis of muscle weakness...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Polymorphisme génétique › Polymorphisme de nucléotide simple › Genome-wide meta-analysis of muscle weakness...
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Manifestations neurologiques › Manifestations neuromusculaires › Amyotrophie › Sarcopénie › Genome-wide meta-analysis of muscle weakness...