Protective effects of growth hormone-releasing hormone analogs in DSS-induced colitis in mice.
Animals
Anti-Inflammatory Agents
/ pharmacology
Biomarkers
Biopsy
Colitis
/ etiology
Cytokines
/ metabolism
Dextran Sulfate
/ adverse effects
Dinoprostone
/ metabolism
Disease Models, Animal
Growth Hormone-Releasing Hormone
/ analogs & derivatives
Inflammation Mediators
/ metabolism
Intestinal Mucosa
/ metabolism
L-Lactate Dehydrogenase
/ metabolism
Lipopolysaccharides
/ adverse effects
Mice
Nitrites
/ metabolism
Protective Agents
/ pharmacology
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
28 01 2021
28 01 2021
Historique:
received:
29
09
2020
accepted:
08
01
2021
entrez:
29
1
2021
pubmed:
30
1
2021
medline:
18
9
2021
Statut:
epublish
Résumé
Besides its metabolic and endocrine effects, growth hormone (GH)-releasing hormone (GHRH) is involved in the modulation of inflammation. Recently synthetized GHRH antagonist MIA-690 and MR-409, GHRH agonist, developed by us have shown potent pharmacological effects in various experimental paradigms. However, whether their administration modify resistance to chronic inflammatory stimuli in colon is still unknown. Ex vivo results demonstrated that MIA-690 and MR-409 inhibited production of pro-inflammatory and oxidative markers induced by lipopolysaccharide on isolated mouse colon specimens. In vivo, both MIA-690 and MR-409 have also been able to decrease the responsiveness to nociceptive stimulus, in hot plate test. Additionally, both peptides also induced a decreased sensitivity to acute and persistent inflammatory stimuli in male mice, in formalin test and dextran sodium sulfate (DSS)-induced colitis model, respectively. MIA-690 and MR-409 attenuate DSS-induced colitis with particular regard to clinical manifestations, histopathological damage and release of pro-inflammatory and oxidative markers in colon specimens. Respect to MR-409, MIA-690 showed higher efficacy in inhibiting prostaglandin (PG)E
Identifiants
pubmed: 33510215
doi: 10.1038/s41598-021-81778-4
pii: 10.1038/s41598-021-81778-4
pmc: PMC7844299
doi:
Substances chimiques
Anti-Inflammatory Agents
0
Biomarkers
0
Cytokines
0
Inflammation Mediators
0
Lipopolysaccharides
0
Nitrites
0
Protective Agents
0
Growth Hormone-Releasing Hormone
9034-39-3
Dextran Sulfate
9042-14-2
L-Lactate Dehydrogenase
EC 1.1.1.27
Dinoprostone
K7Q1JQR04M
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2530Références
PLoS One. 2012;7(9):e38801
pubmed: 22962574
Neuropharmacology. 1988 Oct;27(10):1019-25
pubmed: 2853311
Nat Rev Cancer. 2004 Jul;4(7):505-18
pubmed: 15229476
Exp Eye Res. 2019 Apr;181:277-284
pubmed: 30831084
J Endocrinol. 2001 May;169(2):205-31
pubmed: 11312139
Acta Histochem. 2002;104(2):185-92
pubmed: 12086339
Molecules. 2019 Aug 19;24(16):
pubmed: 31430921
Behav Brain Res. 2001 Nov 1;125(1-2):65-73
pubmed: 11682095
Peptides. 2017 Mar;89:60-70
pubmed: 28130121
J Endocrinol Invest. 2016 Jul;39(7):721-7
pubmed: 26891937
Cell Rep. 2017 Apr 11;19(2):225-234
pubmed: 28402847
Proc Natl Acad Sci U S A. 2017 Dec 12;114(50):13248-13253
pubmed: 29180438
Chin J Integr Med. 2014 Nov;20(11):865-9
pubmed: 24126972
Inflamm Bowel Dis. 2007 Aug;13(8):1016-23
pubmed: 17476678
Oncotarget. 2018 Jun 19;9(47):28745-28756
pubmed: 29983893
Prostate. 2018 Sep;78(13):970-980
pubmed: 29786867
Proc Natl Acad Sci U S A. 1999 Dec 21;96(26):14894-8
pubmed: 10611309
Neuroscience. 2014 Jan 31;258:238-45
pubmed: 24239719
Proc Natl Acad Sci U S A. 2019 Feb 5;116(6):2226-2231
pubmed: 30659154
Gut. 1998 Jan;42(1):42-6
pubmed: 9505884
Proc Natl Acad Sci U S A. 2008 Dec 23;105(51):20470-5
pubmed: 19075233
Oncogene. 2016 May 19;35(20):2634-44
pubmed: 26364612
Gen Pharmacol. 1998 Nov;31(5):809-10
pubmed: 9809483
Sci Rep. 2020 Mar 11;10(1):4850
pubmed: 32161298
Gut. 2000 Dec;47(6):804-11
pubmed: 11076879
Lancet. 1984 Nov 24;2(8413):1208-9
pubmed: 6150249
Trends Endocrinol Metab. 2011 Aug;22(8):311-7
pubmed: 21530304
Anesth Analg. 1997 Nov;85(5):1112-5
pubmed: 9356110
EBioMedicine. 2018 Nov;37:557-562
pubmed: 30344124
Cardiovasc Res. 2009 Jul 15;83(2):303-12
pubmed: 19293247
Proc Natl Acad Sci U S A. 2010 Feb 9;107(6):2604-9
pubmed: 20133784
Endocrinology. 2019 Jul 1;160(7):1600-1612
pubmed: 31070727
Prog Neuropsychopharmacol Biol Psychiatry. 2004 Jul;28(4):625-31
pubmed: 15276687
Oncotarget. 2016 Aug 16;7(33):52661-52672
pubmed: 27494841
Growth Horm IGF Res. 2015 Apr;25(2):80-4
pubmed: 25588992
Clin Gastroenterol Hepatol. 2007 Jun;5(6):714-20
pubmed: 17481962
Growth Horm IGF Res. 2013 Dec;23(6):237-42
pubmed: 24021480
Mediators Inflamm. 2016;2016:5359768
pubmed: 27478308
Proc Natl Acad Sci U S A. 2015 Nov 3;112(44):13651-6
pubmed: 26474831
Proc Natl Acad Sci U S A. 2017 Nov 7;114(45):12033-12038
pubmed: 29078377
Endocrinology. 2015 Sep;156(9):3239-52
pubmed: 26110916
Front Oncol. 2015 Oct 15;5:230
pubmed: 26528439
Cell Cycle. 2010 Oct 15;9(20):4110-6
pubmed: 20962577
Growth Horm IGF Res. 2014 Oct;24(5):192-7
pubmed: 25028079
Oncotarget. 2012 Sep;3(9):988-97
pubmed: 22941871
Digestion. 1992;51(1):51-9
pubmed: 1639222
Proc Natl Acad Sci U S A. 1995 May 23;92(11):4872-6
pubmed: 7761415
Proc Natl Acad Sci U S A. 2020 Mar 17;117(11):6067-6074
pubmed: 32123064
Proc Natl Acad Sci U S A. 2012 Jan 10;109(2):559-63
pubmed: 22203988
Proc Natl Acad Sci U S A. 2004 Feb 10;101(6):1708-13
pubmed: 14755056
Trends Immunol. 2005 Oct;26(10):535-42
pubmed: 16109502
J Ginseng Res. 2015 Jan;39(1):14-21
pubmed: 25535472
Nat Rev Endocrinol. 2011 Jan;7(1):11-24
pubmed: 20956999
Methods. 2001 Dec;25(4):402-8
pubmed: 11846609
Nat Clin Pract Endocrinol Metab. 2008 Jan;4(1):33-43
pubmed: 18084344
Proc Natl Acad Sci U S A. 1994 Dec 6;91(25):12298-302
pubmed: 7991622
Digestion. 1994;55(1):44-9
pubmed: 8112497
Prostaglandins Other Lipid Mediat. 2019 Oct;144:106362
pubmed: 31301405
Gastroenterology. 2004 Jun;126(7):1657-64
pubmed: 15188158
Peptides. 2014 Feb;52:104-12
pubmed: 24373935
Proc Natl Acad Sci U S A. 2020 Mar 24;117(12):6726-6732
pubmed: 32156725
J Pharmacol Pharmacother. 2013 Oct;4(4):303-6
pubmed: 24250214
Proc Natl Acad Sci U S A. 2014 Dec 23;111(51):18303-8
pubmed: 25489106
Horm Metab Res. 2020 May;52(5):336-339
pubmed: 32403147
Aging (Albany NY). 2012 Nov;4(11):755-67
pubmed: 23211425
Proc Natl Acad Sci U S A. 2018 Nov 20;115(47):12028-12033
pubmed: 30373845