Minor allele of GJA1 gene polymorphism is associated with higher heart rate during atrial fibrillation.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
28 01 2021
28 01 2021
Historique:
received:
06
10
2020
accepted:
15
01
2021
entrez:
29
1
2021
pubmed:
30
1
2021
medline:
18
9
2021
Statut:
epublish
Résumé
Atrial fibrillation (AF) tachycardia causes heart failure and requires more attention. The genetic background of individual heart rate (HR) variations during AF are unclear. We hypothesized that HR-associated single nucleotide polymorphisms (SNPs) reported in Genome-Wide Association Studies (GWAS) are also associated with HR during AF. We enrolled patients with persistent AF (311 for screening and 146 for replication) who underwent AF ablation and were genotyped for the 21 h-associated SNPs reported in GWAS. The patients underwent 24-h Holter monitoring before AF ablation and electrophysiological study after AF ablation during sinus rhythm. Only the GJA1 SNP rs1015451 (T>C) was significantly associated with total HR (TT 110,643 ± 17,542 beats/day, TC 116,350 ± 19,060 beats/day, CC 122,163 ± 25,684 beats/day, P = 8.5 × 10
Identifiants
pubmed: 33510344
doi: 10.1038/s41598-021-82117-3
pii: 10.1038/s41598-021-82117-3
pmc: PMC7844413
doi:
Substances chimiques
Biomarkers
0
Connexin 43
0
GJA1 protein, human
0
MicroRNAs
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2549Références
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