PAI-1 protein is a key molecular effector in the transition from normal to PTSD-like fear memory.
Journal
Molecular psychiatry
ISSN: 1476-5578
Titre abrégé: Mol Psychiatry
Pays: England
ID NLM: 9607835
Informations de publication
Date de publication:
09 2021
09 2021
Historique:
received:
16
06
2020
accepted:
11
01
2021
revised:
18
12
2020
pubmed:
30
1
2021
medline:
1
2
2022
entrez:
29
1
2021
Statut:
ppublish
Résumé
Moderate stress increases memory and facilitates adaptation. In contrast, intense stress can induce pathological memories as observed in post-traumatic stress disorders (PTSD). A shift in the balance between the expression of tPA and PAI-1 proteins is responsible for this transition. In conditions of moderate stress, glucocorticoid hormones increase the expression of the tPA protein in the hippocampal brain region which by triggering the Erk1/2
Identifiants
pubmed: 33510345
doi: 10.1038/s41380-021-01024-1
pii: 10.1038/s41380-021-01024-1
pmc: PMC8589667
doi:
Substances chimiques
Glucocorticoids
0
Plasminogen Activator Inhibitor 1
0
SERPINE1 protein, human
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
4968-4981Informations de copyright
© 2021. The Author(s), under exclusive licence to Springer Nature Limited part of Springer Nature.
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