Serotonin 5-HT
Amino Acid Substitution
Animals
Behavior, Animal
/ drug effects
Frontal Lobe
/ drug effects
Gene Expression Regulation
/ genetics
Genotype
Hyperkinesis
/ genetics
Indoles
/ pharmacology
Male
Mice
Mutation
/ genetics
Prepulse Inhibition
/ drug effects
Proto-Oncogene Proteins c-fos
/ biosynthesis
Receptor, Serotonin, 5-HT1B
/ drug effects
Sensory Gating
/ drug effects
Serotonin 5-HT1 Receptor Agonists
/ pharmacology
Serotonin Plasma Membrane Transport Proteins
/ genetics
5-HT1B
ASD
Autism spectrum disorder
OCD
Obsessive-compulsive disorder
Orbitofrontal cortex
Prepulse inhibition of startle
RU24969
Sensorimotor gating
Serotonin
Journal
Psychopharmacology
ISSN: 1432-2072
Titre abrégé: Psychopharmacology (Berl)
Pays: Germany
ID NLM: 7608025
Informations de publication
Date de publication:
Apr 2021
Apr 2021
Historique:
received:
20
07
2020
accepted:
28
12
2020
pubmed:
30
1
2021
medline:
31
3
2021
entrez:
29
1
2021
Statut:
ppublish
Résumé
Elevated whole-blood serotonin (5-HT) is a robust biomarker in ~ 30% of patients with autism spectrum disorders, in which repetitive behavior is a core symptom. Furthermore, elevated whole-blood 5-HT has also been described in patients with pediatric obsessive-compulsive disorder. The 5-HT We examined the impact of the SERT Ala56 mutation, which leads to enhanced SERT function, on 5-HT Specific binding to 5-HT While enhanced SERT function increased 5-HT While reducing 5-HT
Identifiants
pubmed: 33511450
doi: 10.1007/s00213-020-05758-8
pii: 10.1007/s00213-020-05758-8
pmc: PMC8728944
mid: NIHMS1765584
doi:
Substances chimiques
Indoles
0
Proto-Oncogene Proteins c-fos
0
Receptor, Serotonin, 5-HT1B
0
Serotonin 5-HT1 Receptor Agonists
0
Serotonin Plasma Membrane Transport Proteins
0
Slc6a4 protein, mouse
0
5-methoxy 3-(1,2,3,6-tetrahydro-4-pyridinyl)1H indole
2ISE72RACC
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1111-1120Subventions
Organisme : NIMH NIH HHS
ID : K08 MH081066
Pays : United States
Organisme : NIH HHS
ID : MH094604
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH094604
Pays : United States
Organisme : NIH HHS
ID : T32MH016434
Pays : United States
Organisme : NIMH NIH HHS
ID : T32 MH016434
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH114296
Pays : United States
Organisme : NIH HHS
ID : MH081066
Pays : United States
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