Tramadol-induced hypoglycemia: A pharmacovigilance study.
analgesics
codeine
hypoglycemia
tramadol
Journal
Fundamental & clinical pharmacology
ISSN: 1472-8206
Titre abrégé: Fundam Clin Pharmacol
Pays: England
ID NLM: 8710411
Informations de publication
Date de publication:
10 2021
10 2021
Historique:
revised:
20
01
2021
received:
10
12
2020
accepted:
25
01
2021
pubmed:
30
1
2021
medline:
4
1
2022
entrez:
29
1
2021
Statut:
ppublish
Résumé
Several papers have reported that tramadol can induce hypoglycemia. However, in some reports, confounding factors can be found, like coadministration of hypoglycemic drugs. We used the WHO pharmacovigilance database (VigiBase®) to investigate whether tramadol alone could be associated with hypoglycemia. All 2010–2019 ICSRs (Individual Case Safety Reports) with the PT term “hypoglycemia” and tramadol were included. Two disproportionality analyses were performed: 1/after inclusion of all reports, 2/after exclusion of concomitant hypoglycemic drugs. Results are expressed as Reporting Odds Ratios (ROR; 95% CI). Among 10 038 436 ICSRs, 97 639 were included. In comparison with codeine, a significant association was found between tramadol use and reports of hypoglycemia before [ROR = 1.54 (1.43–1.66)] or after [ROR = 1.43 (1.31–1.56)] exclusion of hypoglycemic drugs. Tramadol use is associated with a higher risk of hypoglycemia reports than codeine, the other step 2 analgesic, in the presence as well as in the absence of other hypoglycemic drugs. We concluded that hypoglycemia is an adverse drug reaction of tramadol, which can be observed in diabetic as well as in non-diabetic patients.
Substances chimiques
Analgesics, Opioid
0
Tramadol
39J1LGJ30J
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
933-936Informations de copyright
© 2021 Société Française de Pharmacologie et de Thérapeutique.
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