Structure of the human secretory immunoglobulin M core.

Cell Line Humans Immunoglobulin A, Secretory / chemistry Immunoglobulin J-Chains / metabolism Immunoglobulin M / chemistry Models, Molecular Protein Conformation Secretory Component / metabolism Structural Homology, Protein Transcytosis
cryo-electron microscopy immunoglobulin mucosa transcytosis

Journal

Structure (London, England : 1993)
ISSN: 1878-4186
Titre abrégé: Structure
Pays: United States
ID NLM: 101087697

Informations de publication

Date de publication:
03 06 2021
Historique:
received: 15 10 2020
revised: 22 12 2020
accepted: 08 01 2021
pubmed: 30 1 2021
medline: 14 1 2022
entrez: 29 1 2021
Statut: ppublish

Résumé

Immunoglobulins (Ig) A and M are the only human antibodies that form oligomers and undergo transcytosis to mucosal secretions via the polymeric Ig receptor (pIgR). When complexed with the J-chain (JC) and the secretory component (SC) of pIgR, secretory IgA and IgM (sIgA and sIgM) play critical roles in host-pathogen defense. Recently, we determined the structure of sIgA-Fc which elucidated the mechanism of polymeric IgA assembly and revealed an extensive binding interface between IgA-Fc, JC, and SC. Despite low sequence identity shared with IgA-Fc, IgM-Fc also undergoes JC-mediated assembly and binds pIgR. Here, we report the structure of sIgM-Fc and carryout a systematic comparison to sIgA-Fc. Our structural analysis reveals a remarkably conserved mechanism of JC-templated oligomerization and SC recognition of both IgM and IgA through a highly conserved network of interactions. These studies reveal the structurally conserved features of sIgM and sIgA required for function in mucosal immunity.

Identifiants

DOI: 10.1016/j.str.2021.01.002 PMID: 33513362
pubmed: 33513362
pii: S0969-2126(21)00002-2
doi: 10.1016/j.str.2021.01.002
pii:
doi:

Substances chimiques

Immunoglobulin A, Secretory 0
Immunoglobulin J-Chains 0
Immunoglobulin M 0
Secretory Component 0
secretory IgM 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

564-571.e3

Informations de copyright

Copyright © 2021 Elsevier Ltd. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of interests All authors are employees of Genentech, Inc., a member of the Roche Group, and may hold stock and options.

Auteurs

Nikit Kumar (N)

Department of Structural Biology, Genentech, 1 DNA Way, South San Francisco, CA 94080, USA.

Christopher P Arthur (CP)

Department of Structural Biology, Genentech, 1 DNA Way, South San Francisco, CA 94080, USA.

Claudio Ciferri (C)

Department of Structural Biology, Genentech, 1 DNA Way, South San Francisco, CA 94080, USA.

Marissa L Matsumoto (ML)

Department of Structural Biology, Genentech, 1 DNA Way, South San Francisco, CA 94080, USA. Electronic address: matsumoto.marissa@gene.com.

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Classifications MeSH

questionsmedicales.fr › Cellules › Cellules cultivées › Lignée cellulaire › Structure of the human secretory immunoglobulin M core.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Structure of the human secretory immunoglobulin M core.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Anticorps › Isotypes des immunoglobulines › Immunoglobuline A › Immunoglobuline A sécrétoire › Structure of the human secretory immunoglobulin M core.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Sous-unités des immunoglobulines › Chaines J des immunoglobulines › Structure of the human secretory immunoglobulin M core.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Anticorps › Isotypes des immunoglobulines › Immunoglobuline M › Structure of the human secretory immunoglobulin M core.
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles moléculaires › Structure of the human secretory immunoglobulin M core.
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Conformation moléculaire › Conformation des protéines › Structure of the human secretory immunoglobulin M core.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Sous-unités des immunoglobulines › Composant sécrétoire › Structure of the human secretory immunoglobulin M core.
questionsmedicales.fr › Phénomènes génétiques › Similitude structurale de protéines › Structure of the human secretory immunoglobulin M core.
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Exocytose › Transcytose › Structure of the human secretory immunoglobulin M core.