Semaphorins and Plexins in central nervous system patterning: the key to it all?

Cell Adhesion Molecules Central Nervous System / physiology Humans Nerve Tissue Proteins Semaphorins

Journal

Current opinion in neurobiology
ISSN: 1873-6882
Titre abrégé: Curr Opin Neurobiol
Pays: England
ID NLM: 9111376

Informations de publication

Date de publication:
02 2021
Historique:
received: 13 11 2020
revised: 21 12 2020
accepted: 22 12 2020
pubmed: 30 1 2021
medline: 26 5 2021
entrez: 29 1 2021
Statut: ppublish

Résumé

Semaphorins and Plexins constitute one of the largest family of guidance molecules and receptors involved in setting critical biological steps for central nervous system development. The role of these molecules in axonal development has been extensively characterized but Semaphorins and Plexins are also involved in a variety of other developmental processes, spanning from cell polarization to migration, laminar segregation and neuronal maturation. In this review, we aim to gather discoveries carried in the field of neurodevelopment over the last decade, during which Semaphorin/Plexin complexes have emerged as key regulators of neurogenesis, neural cell migration and adult gliogenesis. As well, we report mechanisms that brought a better understanding of axonal midline crossing.

Identifiants

DOI: 10.1016/j.conb.2020.12.014 PMID: 33513538
pubmed: 33513538
pii: S0959-4388(20)30205-1
doi: 10.1016/j.conb.2020.12.014
pii:
doi:

Substances chimiques

Cell Adhesion Molecules 0
Nerve Tissue Proteins 0
Semaphorins 0
plexin 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

224-232

Informations de copyright

Copyright © 2020 The Author(s). Published by Elsevier Ltd.. All rights reserved.

Auteurs

Greta Limoni (G)

Department of Basic Neuroscience, University Medical Center, University of Geneva, Rue Michel-Servet 1, 1211 Genève 4, Switzerland. Electronic address: greta.limoni@unige.ch.

Mathieu Niquille (M)

Department of Basic Neuroscience, University Medical Center, University of Geneva, Rue Michel-Servet 1, 1211 Genève 4, Switzerland. Electronic address: mathieu.niquille@unige.ch.

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Classifications MeSH

questionsmedicales.fr › Facteurs biologiques › Antigènes › Antigènes de surface › Molécules d'adhérence cellulaire › Semaphorins and Plexins in central nervous...
questionsmedicales.fr › Système nerveux › Système nerveux central › Semaphorins and Plexins in central nervous...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Semaphorins and Plexins in central nervous...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de tissu nerveux › Semaphorins and Plexins in central nervous...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Sémaphorines › Semaphorins and Plexins in central nervous...