Aging adipose: Depot location dictates age-associated expansion and dysfunction.
Brown adipose tissue
Osteoporosis
Sarcopenia
Senescence
White adipose tissue
Journal
Ageing research reviews
ISSN: 1872-9649
Titre abrégé: Ageing Res Rev
Pays: England
ID NLM: 101128963
Informations de publication
Date de publication:
05 2021
05 2021
Historique:
received:
25
10
2020
revised:
09
12
2020
accepted:
18
01
2021
pubmed:
31
1
2021
medline:
20
4
2021
entrez:
30
1
2021
Statut:
ppublish
Résumé
Adipose tissue has a variety of diverse functions that maintain energy homeostasis. In conditions of excess energy availability, adipose tissue increases its lipid storage and communicates the nutritional abundance to various organs in the body. In conditions of energy depletion, such as fasting, cold exposure, or prolonged exercise, triglycerides stored in adipose tissue are released as free fatty acids to support the shift to catabolic metabolism. These diverse functions of storage, communication, and energy homeostasis are shared between numerous adipose depots including subcutaneous, visceral, brown, beige, intramuscular, marrow, and dermal adipose tissue. As organisms age, the cellular composition of these depots shifts to facilitate increased inflammatory cell infiltration, decreased vasculature, and increased adipocyte quantity and lipid droplet size. The purpose of this review is to give a comprehensive overview of the molecular and cellular changes that occur in various aged adipose depots and discuss their impact on physiology. The molecular signature of aged adipose leads to higher prevalence of metabolic disease in aged populations including type 2 diabetes, cardiovascular disease, Alzheimer's disease, and certain types of cancer.
Identifiants
pubmed: 33515751
pii: S1568-1637(21)00006-4
doi: 10.1016/j.arr.2021.101259
pmc: PMC8379680
mid: NIHMS1731675
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
101259Subventions
Organisme : NIAMS NIH HHS
ID : K12 AR084227
Pays : United States
Organisme : NICHD NIH HHS
ID : K12 HD101368
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG017266
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK020579
Pays : United States
Informations de copyright
Published by Elsevier B.V.
Références
Ageing Res Rev. 2020 May;59:101040
pubmed: 32112889
Aging (Albany NY). 2016 Jul;8(7):1457-69
pubmed: 27434510
Cell Metab. 2014 Jan 7;19(1):162-171
pubmed: 24374218
Metabolism. 2017 Sep;74:1-9
pubmed: 28764843
Skeletal Radiol. 1985;14(1):10-9
pubmed: 3895447
Nat Med. 2017 May;23(5):631-637
pubmed: 28346411
Nat Commun. 2020 Jun 18;11(1):3097
pubmed: 32555194
Age (Dordr). 2015 Oct;37(5):87
pubmed: 26307156
Science. 1996 Feb 2;271(5249):665-8
pubmed: 8571133
J Immunol. 2011 Dec 15;187(12):6208-16
pubmed: 22075699
Cell Rep. 2016 Sep 13;16(11):2991-3002
pubmed: 27626667
Aging (Albany NY). 2016 Oct 24;8(10):2525-2537
pubmed: 27777379
Diabetes. 2014 Dec;63(12):4089-99
pubmed: 25056438
Cell. 2013 Jun 6;153(6):1194-217
pubmed: 23746838
Cell Metab. 2008 May;7(5):410-20
pubmed: 18460332
Int J Exp Pathol. 2017 Apr;98(2):100-108
pubmed: 28543963
Arch Osteoporos. 2018 Sep 14;13(1):97
pubmed: 30218261
Aging Cell. 2018 Oct;17(5):e12810
pubmed: 30088333
Diabetes. 2018 Nov;67(11):2397-2409
pubmed: 30131393
Physiol Rev. 1998 Apr;78(2):339-58
pubmed: 9562032
Exp Gerontol. 2004 May;39(5):687-99
pubmed: 15130663
Cell Metab. 2019 Dec 3;30(6):1024-1039.e6
pubmed: 31735593
Cell Metab. 2014 May 6;19(5):810-20
pubmed: 24709624
Aging (Albany NY). 2014 Jul;6(7):575-86
pubmed: 25063774
J Physiol. 2014 Sep 15;592(18):4083-96
pubmed: 25038241
Ageing Res Rev. 2009 Oct;8(4):339-48
pubmed: 19576300
Diabetes. 2010 Nov;59(11):2817-25
pubmed: 20713683
Nat Commun. 2014 Jun 19;5:4099
pubmed: 24942009
Biochem Biophys Res Commun. 2014 Apr 18;446(4):1243-9
pubmed: 24685483
Cell Metab. 2017 Jan 10;25(1):166-181
pubmed: 27889388
Nat Med. 2013 May;19(5):635-9
pubmed: 23603815
Cell Metab. 2014 Dec 2;20(6):1049-58
pubmed: 25456741
Diabetes. 2011 Oct;60(10):2484-95
pubmed: 21873554
FASEB J. 2019 Jan;33(1):844-856
pubmed: 30052487
Cell Stem Cell. 2018 Aug 02;23(2):193-209.e5
pubmed: 30017591
PLoS One. 2013 Aug 14;8(8):e72367
pubmed: 23967297
Cell Metab. 2013 May 7;17(5):798-805
pubmed: 23663743
Nat Commun. 2016 Jan 05;7:10184
pubmed: 26729601
Med Clin North Am. 2018 Jan;102(1):65-85
pubmed: 29156188
Cell. 2012 Jul 20;150(2):366-76
pubmed: 22796012
Front Immunol. 2018 Feb 09;9:169
pubmed: 29479350
Cell Metab. 2017 Nov 7;26(5):753-763.e7
pubmed: 28988821
Obes Rev. 2012 Dec;13 Suppl 2:30-9
pubmed: 23107257
EBioMedicine. 2019 Sep;47:446-456
pubmed: 31542391
J Clin Endocrinol Metab. 2007 Jun;92(6):2240-7
pubmed: 17374712
Nat Rev Mol Cell Biol. 2011 Sep 28;12(11):722-34
pubmed: 21952300
Nat Med. 2012 Aug;18(8):1279-85
pubmed: 22842477
J Clin Invest. 2006 Nov;116(11):3015-25
pubmed: 17053832
BMC Genomics. 2011 May 05;12:212
pubmed: 21545734
Age (Dordr). 2016 Feb;38(1):23
pubmed: 26846415
Aging (Albany NY). 2017 Sep 7;9(9):1971-1982
pubmed: 28898202
PLoS One. 2019 Aug 23;14(8):e0221366
pubmed: 31442231
Cell Metab. 2006 May;3(5):333-41
pubmed: 16679291
Endocr J. 2010;57(10):925-30
pubmed: 20686275
Nature. 2020 Jul;583(7817):590-595
pubmed: 32669714
J Endocrinol Invest. 2002 Nov;25(10):823-35
pubmed: 12508945
Aging Cell. 2012 Dec;11(6):1074-83
pubmed: 23020201
Obesity (Silver Spring). 2016 Mar;24(3):597-605
pubmed: 26916240
Proc Natl Acad Sci U S A. 2017 May 16;114(20):5265-5270
pubmed: 28461471
Cell Stem Cell. 2017 Jun 1;20(6):771-784.e6
pubmed: 28330582
Development. 2013 Oct;140(19):3939-49
pubmed: 24046315
Front Endocrinol (Lausanne). 2019 Jun 20;10:368
pubmed: 31281288
Physiol Rev. 2004 Jan;84(1):277-359
pubmed: 14715917
Eur J Clin Invest. 2011 Feb;41(2):126-33
pubmed: 20874854
Diabetes. 2009 Feb;58(2):385-93
pubmed: 19008342
Nature. 2009 Aug 27;460(7259):1154-8
pubmed: 19641492
Mol Aspects Med. 2013 Feb;34(1):1-11
pubmed: 23068073
Am J Physiol Endocrinol Metab. 2011 Oct;301(4):E599-607
pubmed: 21586698
Cell Metab. 2017 Nov 7;26(5):764-777.e5
pubmed: 28988822
Front Endocrinol (Lausanne). 2019 Feb 26;10:114
pubmed: 30863366
Diabetes. 2010 Jan;59(1):105-9
pubmed: 19846802
Cell Metab. 2018 Jun 05;27(6):1357
pubmed: 29874569
Mol Metab. 2019 Jun;24:1-17
pubmed: 31003944
Nat Commun. 2019 Jun 21;10(1):2757
pubmed: 31227697
Nat Commun. 2015 Aug 06;6:7808
pubmed: 26245716
Nat Med. 2015 Apr;21(4):389-94
pubmed: 25774848
PLoS One. 2014 Jan 15;9(1):e85161
pubmed: 24454809
Mol Cell Biol. 2009 Aug;29(16):4467-83
pubmed: 19546236
Front Endocrinol (Lausanne). 2019 Mar 11;10:137
pubmed: 30915034
Proc Natl Acad Sci U S A. 2015 Nov 17;112(46):E6301-10
pubmed: 26578790
Nature. 2017 Oct 5;550(7674):119-123
pubmed: 28953873
JCI Insight. 2016 Aug 18;1(13):e87146
pubmed: 27668285
Am J Physiol. 1990 Feb;258(2 Pt 1):C206-10
pubmed: 2305864
Nat Methods. 2019 Sep;16(9):809-812
pubmed: 31406385
J Gerontol A Biol Sci Med Sci. 2015 Nov;70(11):1320-9
pubmed: 25324219
Cell. 2014 Jun 5;157(6):1339-1352
pubmed: 24906151
Am J Physiol Endocrinol Metab. 2013 Sep 1;305(5):E567-72
pubmed: 23839524
Exp Gerontol. 2014 May;53:1-6
pubmed: 24508922
Front Physiol. 2017 Feb 15;8:87
pubmed: 28261109
Nat Metab. 2019 Sep;1(9):886-898
pubmed: 32313871
Obesity (Silver Spring). 2018 Jan;26(1):135-140
pubmed: 29178600
Cell Metab. 2012 Sep 5;16(3):336-47
pubmed: 22958919
Cell Metab. 2013 Oct 1;18(4):519-32
pubmed: 24093676
Elife. 2017 Oct 11;6:
pubmed: 29019320
Nat Med. 2018 Mar;24(3):292-303
pubmed: 29400713
J Gerontol A Biol Sci Med Sci. 2001 Mar;56(3):M146-56
pubmed: 11253156
J Clin Invest. 2020 Jan 2;130(1):247-257
pubmed: 31573981
J Aging Res. 2012;2012:629637
pubmed: 22500231
J Transl Med. 2011 Jan 18;9:10
pubmed: 21244679
J Immunol. 2007 Oct 1;179(7):4829-39
pubmed: 17878382
Cell Metab. 2020 Jul 7;32(1):1-3
pubmed: 32589948
Stem Cell Res. 2012 Mar;8(2):215-25
pubmed: 22265741
Elife. 2015 Dec 19;4:e12997
pubmed: 26687007
Nat Rev Mol Cell Biol. 2016 Aug;17(8):480-95
pubmed: 27251423
Biogerontology. 2001;2(3):165-71
pubmed: 11708718
Mol Cell Biol. 2009 Mar;29(6):1575-91
pubmed: 19114551
J Am Geriatr Soc. 2002 May;50(5):897-904
pubmed: 12028178
N Engl J Med. 2009 Apr 9;360(15):1509-17
pubmed: 19357406
Clin Sci (Lond). 2020 Jan 31;134(2):315-330
pubmed: 31998947
JCI Insight. 2017 Mar 9;2(5):e90349
pubmed: 28289709
Diabetologia. 2013 Jun;56(6):1403-12
pubmed: 23494472
Cell Metab. 2017 Sep 5;26(3):509-522.e6
pubmed: 28877455
J Gerontol A Biol Sci Med Sci. 2011 Aug;66(8):888-95
pubmed: 21572082
NCHS Data Brief. 2012 Sep;(106):1-8
pubmed: 23102091
Aging Cell. 2017 Jun;16(3):497-507
pubmed: 28156058
Diabetes. 2010 Jul;59(7):1789-93
pubmed: 20357363
Cell Metab. 2020 Mar 3;31(3):580-591.e5
pubmed: 32032542
J Clin Invest. 2019 Dec 2;129(12):5327-5342
pubmed: 31503545
Front Endocrinol (Lausanne). 2016 Apr 13;7:30
pubmed: 27148161
Biochem Biophys Res Commun. 2018 Jun 7;500(3):682-690
pubmed: 29678576
J Clin Invest. 2003 Dec;112(12):1796-808
pubmed: 14679176
Nature. 2015 Dec 3;528(7580):137-41
pubmed: 26580014
J Clin Invest. 2017 Jan 3;127(1):74-82
pubmed: 28045400
Endocrinology. 2014 Feb;155(2):485-501
pubmed: 24248466
Aging Cell. 2012 Apr;11(2):284-96
pubmed: 22221695
J Nutr Health Aging. 2014 May;18(5):532-8
pubmed: 24886741
Am J Physiol Regul Integr Comp Physiol. 2001 Jun;280(6):R1772-80
pubmed: 11353682