Judith Simcox

Affiliations

Department of Biochemistry, University of Wisconsin Madison, USA. Electronic address: jsimcox@wisc.edu.

Publications (27)

Aging adipose: Depot location dictates age-associated expansion and dysfunction.

Ageing research reviews

Avec: Helaina Von Bank , Charlie Kirsh , Judith Simcox

Mitochondrial pyruvate carrier is required for optimal brown fat thermogenesis.

eLife

Avec: Vanja Panic , Stephanie Pearson , James Banks , Trevor S Tippetts , Jesse N Velasco-Silva , Sanghoon Lee , Judith Simcox , Gisela Geoghegan , Claire L Bensard , Tyler van Ry , Will L Holland , Scott A Summers , James Cox , Gregory S Ducker , Jared Rutter , Claudio J Villanueva

Sex and genetic background define the metabolic, physiologic, and molecular response to protein restriction.

Cell metabolism

Avec: Cara L Green , Heidi H Pak , Nicole E Richardson , Victoria Flores , Deyang Yu , Jay L Tomasiewicz , Sabrina N Dumas , Katherine Kredell , Jesse W Fan , Charlie Kirsh , Krittisak Chaiyakul , Michaela E Murphy , Reji Babygirija , Gregory A Barrett-Wilt , Joshua Rabinowitz , Irene M Ong , Cholsoon Jang , Judith Simcox , Dudley W Lamming

Frontiers in endocrinology

Avec: Liam D Hurley , Hugo Lee , Gina Wade , Judith Simcox , Feyza Engin

Membrane Bound O-Acyltransferase 7 (MBOAT7) Shapes Lysosomal Lipid Homeostasis and Function to Control Alcohol-Associated Liver Injury.

bioRxiv : the preprint server for biology

Avec: Venkateshwari Varadharajan , Lyappan Ramachandiran , William J Massey , Raghav Jain , Rakhee Banerjee , Anthony J Horak , Megan R McMullen , Emily Huang , Annette Bellar , Shuhui W Lorkowski , Kailash Guilshan , Robert N Helsley , Isabella James , Vai Pathak , Jaividhya Dasarathy , Nicole Welch , Srinivasan Dasarathy , David Streem , Ofer Reizes , Daniela S Allende , Jonathan D Smith , Judith Simcox , Laura E Nagy , J Mark Brown

Protein restriction slows the development and progression of Alzheimer's disease in mice.

Research square

Avec: Reji Babygirija , Michelle M Sonsalla , Jessica H Han , Isabella James , Cara L Green , Mariah F Calubag , Jericha Mill , Gina Wade , Anna Tobon , John Michael , Michaela M Trautman , Ryan Matoska , Chung-Yang Yeh , Isaac Grunow , Heidi H Pak , Michael J Rigby , John M Denu , Luigi Puglielli , Judith Simcox , Dudley W Lamming

Loss of TLE3 promotes the mitochondrial program in beige adipocytes and improves glucose metabolism.

Genes & development

Avec: Stephanie Pearson , Anne Loft , Prashant Rajbhandari , Judith Simcox , Sanghoon Lee , Peter Tontonoz , Susanne Mandrup , Claudio J Villanueva

Targeted deletion of Tcf7l2 in adipocytes promotes adipocyte hypertrophy and impaired glucose metabolism.

Molecular metabolism

Avec: Gisela Geoghegan , Judith Simcox , Marcus M Seldin , Timothy J Parnell , Chris Stubben , Steven Just , Lori Begaye , Aldons J Lusis , Claudio J Villanueva

Determination of tissue contributions to the circulating lipid pool in cold exposure via systematic assessment of lipid profiles.

Journal of lipid research

Avec: Raghav Jain , Gina Wade , Irene Ong , Bhagirath Chaurasia , Judith Simcox

Lipid signatures of chronic pain in female adolescents with and without obesity.

Lipids in health and disease

Avec: Paula A Gonzalez , Judith Simcox , Hershel Raff , Gina Wade , Helaina Von Bank , Steven Weisman , Keri Hainsworth

SON-light activation of glucose regulation.

Cell

Avec: Gisela Geoghegan , Judith Simcox

Ormdl3 regulation of specific ceramides is dispensable for β-cell function and glucose homeostasis under obesogenic conditions.

bioRxiv : the preprint server for biology

Avec: Liam D Hurley , Hugo Lee , Gina Wade , Judith Simcox , Feyza Engin

Dietary restriction of isoleucine increases healthspan and lifespan of genetically heterogeneous mice.

Cell metabolism

Avec: Cara L Green , Michaela E Trautman , Krittisak Chaiyakul , Raghav Jain , Yasmine H Alam , Reji Babygirija , Heidi H Pak , Michelle M Sonsalla , Mariah F Calubag , Chung-Yang Yeh , Anneliese Bleicher , Grace Novak , Teresa T Liu , Sarah Newman , Will A Ricke , Kristina A Matkowskyj , Irene M Ong , Cholsoon Jang , Judith Simcox , Dudley W Lamming

Drosophila HNF4 Directs a Switch in Lipid Metabolism that Supports the Transition to Adulthood.

Developmental cell

Avec: Gilles Storelli , Hyuck-Jin Nam , Judith Simcox , Claudio J Villanueva , Carl S Thummel

Neutral sphingomyelinase regulates mechanotransduction in human engineered cardiac tissues and mouse hearts.

The Journal of physiology

Avec: Daniel G P Turner , Willem J De Lange , Yanlong Zhu , Christopher L Coe , Judith Simcox , Ying Ge , Timothy J Kamp , J Carter Ralphe , Alexey V Glukhov

Restricting dietary protein or dietary isoleucine improves metabolic health in aged mice.

bioRxiv : the preprint server for biology

Avec: Chung-Yang Yeh , Lucas C S Chini , Meredith S Gallagher , Jessica W Davidson , Isaac T Freichels , Mariah F Calubag , Allison C Rodgers , Cara L Green , Reji Babygirija , Michelle M Sonsalla , Heidi H Pak , Michaela Trautman , Timothy A Hacker , Judith Simcox , Dudley W Lamming

Branching out beyond canonical brown adipocyte function.

Cell metabolism

Avec: Helaina Von Bank , Judith Simcox

Lipid Transport in Brown Adipocyte Thermogenesis.

Frontiers in physiology

Avec: Gina Wade , Ayren McGahee , James M Ntambi , Judith Simcox

Membrane-bound

eLife

Avec: Venkateshwari Varadharajan , Iyappan Ramachandiran , William J Massey , Raghav Jain , Rakhee Banerjee , Anthony J Horak , Megan R McMullen , Emily Huang , Annette Bellar , Shuhui W Lorkowski , Kailash Gulshan , Robert N Helsley , Isabella James , Vai Pathak , Jaividhya Dasarathy , Nicole Welch , Srinivasan Dasarathy , David Streem , Ofer Reizes , Daniela S Allende , Jonathan D Smith , Judith Simcox , Laura E Nagy , J Mark Brown

Protein restriction slows the development and progression of pathology in a mouse model of Alzheimer's disease.

Nature communications

Avec: Reji Babygirija , Michelle M Sonsalla , Jericha Mill , Isabella James , Jessica H Han , Cara L Green , Mariah F Calubag , Gina Wade , Anna Tobon , John Michael , Michaela M Trautman , Ryan Matoska , Chung-Yang Yeh , Isaac Grunow , Heidi H Pak , Michael J Rigby , Dominique A Baldwin , Natalie M Niemi , John M Denu , Luigi Puglielli , Judith Simcox , Dudley W Lamming

Diabetes mellitus-Progress and opportunities in the evolving epidemic.

Cell

Avec: E Dale Abel , Anna L Gloyn , Carmella Evans-Molina , Joshua J Joseph , Shivani Misra , Utpal B Pajvani , Judith Simcox , Katalin Susztak , Daniel J Drucker

Mitochondrial Lipid Signaling and Adaptive Thermogenesis.

Metabolites

Avec: Helaina Von Bank , Mae Hurtado-Thiele , Nanami Oshimura , Judith Simcox

The central moTOR of metabolism.

Developmental cell

Avec: Judith Simcox , Dudley W Lamming

Igniting adipocyte thermogenesis.

Cell

Avec: Raghav Jain , Judith Simcox

"Humanizing" mouse environments: Humidity, diurnal cycles and thermoneutrality.

Biochimie

Avec: Ildiko Kasza , Colleen Cuncannan , Julian Michaud , Dave Nelson , Chi-Liang E Yen , Raghav Jain , Judi Simcox , Ormond A MacDougald , Brian W Parks , Caroline M Alexander

Sample multiplexing-based targeted pathway proteomics with real-time analytics reveals the impact of genetic variation on protein expression.

Nature communications

Avec: Qing Yu , Xinyue Liu , Mark P Keller , Jose Navarrete-Perea , Tian Zhang , Sipei Fu , Laura P Vaites , Steven R Shuken , Ernst Schmid , Gregory R Keele , Jiaming Li , Edward L Huttlin , Edrees H Rashan , Judith Simcox , Gary A Churchill , Devin K Schweppe , Alan D Attie , Joao A Paulo , Steven P Gygi

Hepatic Oleate Regulates Insulin-like Growth Factor-Binding Protein 1 Partially through the mTORC1-FGF21 Axis during High-Carbohydrate Feeding.

International journal of molecular sciences

Avec: Lucas M O'Neill , Yar Xin Phang , Zhaojin Liu , Sarah A Lewis , Ahmed Aljohani , Ayren McGahee , Gina Wade , Mugagga Kalyesubula , Judith Simcox , James M Ntambi

Réseau de co-auteurs

Gina Wade 8 collaborations

Dudley W Lamming 6 collaborations

Raghav Jain 6 collaborations

Cara L Green 5 collaborations

Heidi H Pak 5 collaborations

Reji Babygirija 5 collaborations

Helaina Von Bank 4 collaborations

Claudio J Villanueva 4 collaborations

Isabella James 4 collaborations

Michelle M Sonsalla 4 collaborations

Mariah F Calubag 4 collaborations

Chung-Yang Yeh 4 collaborations

Gisela Geoghegan 3 collaborations

Charlie Kirsh 2 collaborations

Stephanie Pearson 2 collaborations

Sanghoon Lee 2 collaborations

Krittisak Chaiyakul 2 collaborations

Irene M Ong 2 collaborations

Cholsoon Jang 2 collaborations

Liam D Hurley 2 collaborations

Hugo Lee 2 collaborations

Feyza Engin 2 collaborations

Venkateshwari Varadharajan 2 collaborations

William J Massey 2 collaborations

Rakhee Banerjee 2 collaborations

Anthony J Horak 2 collaborations

Megan R McMullen 2 collaborations

Emily Huang 2 collaborations

Annette Bellar 2 collaborations

Shuhui W Lorkowski 2 collaborations

Robert N Helsley 2 collaborations

Vai Pathak 2 collaborations

Jaividhya Dasarathy 2 collaborations

Nicole Welch 2 collaborations

Srinivasan Dasarathy 2 collaborations

David Streem 2 collaborations

Ofer Reizes 2 collaborations

Daniela S Allende 2 collaborations

Jonathan D Smith 2 collaborations

Laura E Nagy 2 collaborations

J Mark Brown 2 collaborations

Jessica H Han 2 collaborations

Jericha Mill 2 collaborations

Anna Tobon 2 collaborations

John Michael 2 collaborations

Michaela M Trautman 2 collaborations

Ryan Matoska 2 collaborations

Isaac Grunow 2 collaborations

Michael J Rigby 2 collaborations

John M Denu 2 collaborations

Luigi Puglielli 2 collaborations

Ayren McGahee 2 collaborations

James M Ntambi 2 collaborations

Vanja Panic 1 collaboration

James Banks 1 collaboration

Trevor S Tippetts 1 collaboration

Jesse N Velasco-Silva 1 collaboration

Claire L Bensard 1 collaboration

Tyler van Ry 1 collaboration

Will L Holland 1 collaboration

Scott A Summers 1 collaboration

James Cox 1 collaboration

Gregory S Ducker 1 collaboration

Jared Rutter 1 collaboration

Nicole E Richardson 1 collaboration

Victoria Flores 1 collaboration

Deyang Yu 1 collaboration

Jay L Tomasiewicz 1 collaboration

Sabrina N Dumas 1 collaboration

Katherine Kredell 1 collaboration

Jesse W Fan 1 collaboration

Michaela E Murphy 1 collaboration

Gregory A Barrett-Wilt 1 collaboration

Joshua Rabinowitz 1 collaboration

Lyappan Ramachandiran 1 collaboration

Kailash Guilshan 1 collaboration

Anne Loft 1 collaboration

Prashant Rajbhandari 1 collaboration

Peter Tontonoz 1 collaboration

Susanne Mandrup 1 collaboration

Marcus M Seldin 1 collaboration

Timothy J Parnell 1 collaboration

Chris Stubben 1 collaboration

Steven Just 1 collaboration

Lori Begaye 1 collaboration

Aldons J Lusis 1 collaboration

Irene Ong 1 collaboration

Bhagirath Chaurasia 1 collaboration

Paula A Gonzalez 1 collaboration

Hershel Raff 1 collaboration

Steven Weisman 1 collaboration

Keri Hainsworth 1 collaboration

Michaela E Trautman 1 collaboration

Yasmine H Alam 1 collaboration

Anneliese Bleicher 1 collaboration

Grace Novak 1 collaboration

Teresa T Liu 1 collaboration

Sarah Newman 1 collaboration

Will A Ricke 1 collaboration

Kristina A Matkowskyj 1 collaboration

Gilles Storelli 1 collaboration

Hyuck-Jin Nam 1 collaboration

Carl S Thummel 1 collaboration

Daniel G P Turner 1 collaboration

Willem J De Lange 1 collaboration

Yanlong Zhu 1 collaboration

Christopher L Coe 1 collaboration

Ying Ge 1 collaboration

Timothy J Kamp 1 collaboration

J Carter Ralphe 1 collaboration

Alexey V Glukhov 1 collaboration

Lucas C S Chini 1 collaboration

Meredith S Gallagher 1 collaboration

Jessica W Davidson 1 collaboration

Isaac T Freichels 1 collaboration

Allison C Rodgers 1 collaboration

Michaela Trautman 1 collaboration

Timothy A Hacker 1 collaboration

Iyappan Ramachandiran 1 collaboration

Kailash Gulshan 1 collaboration

Dominique A Baldwin 1 collaboration

Natalie M Niemi 1 collaboration

E Dale Abel 1 collaboration

Anna L Gloyn 1 collaboration

Carmella Evans-Molina 1 collaboration

Joshua J Joseph 1 collaboration

Shivani Misra 1 collaboration

Utpal B Pajvani 1 collaboration

Katalin Susztak 1 collaboration

Daniel J Drucker 1 collaboration

Mae Hurtado-Thiele 1 collaboration

Nanami Oshimura 1 collaboration

Ildiko Kasza 1 collaboration

Colleen Cuncannan 1 collaboration

Julian Michaud 1 collaboration

Dave Nelson 1 collaboration

Chi-Liang E Yen 1 collaboration

Judi Simcox 1 collaboration

Ormond A MacDougald 1 collaboration

Brian W Parks 1 collaboration

Caroline M Alexander 1 collaboration

Qing Yu 1 collaboration

Xinyue Liu 1 collaboration

Mark P Keller 1 collaboration

Jose Navarrete-Perea 1 collaboration

Tian Zhang 1 collaboration

Sipei Fu 1 collaboration

Laura P Vaites 1 collaboration

Steven R Shuken 1 collaboration

Ernst Schmid 1 collaboration

Gregory R Keele 1 collaboration

Jiaming Li 1 collaboration

Edward L Huttlin 1 collaboration

Edrees H Rashan 1 collaboration

Gary A Churchill 1 collaboration

Devin K Schweppe 1 collaboration

Alan D Attie 1 collaboration

Joao A Paulo 1 collaboration

Steven P Gygi 1 collaboration

Lucas M O'Neill 1 collaboration

Yar Xin Phang 1 collaboration

Zhaojin Liu 1 collaboration

Sarah A Lewis 1 collaboration

Ahmed Aljohani 1 collaboration

Mugagga Kalyesubula 1 collaboration