Mitochondrial Lipid Signaling and Adaptive Thermogenesis.
acylcarnitine
brown adipose tissue
cardiolipin
free fatty acid
glycerolipids
ketone
lipids
mitochondria
plasmalogen
thermogenesis
Journal
Metabolites
ISSN: 2218-1989
Titre abrégé: Metabolites
Pays: Switzerland
ID NLM: 101578790
Informations de publication
Date de publication:
22 Feb 2021
22 Feb 2021
Historique:
received:
14
01
2021
revised:
10
02
2021
accepted:
12
02
2021
entrez:
6
3
2021
pubmed:
7
3
2021
medline:
7
3
2021
Statut:
epublish
Résumé
Thermogenesis is an energy demanding process by which endotherms produce heat to maintain their body temperature in response to cold exposure. Mitochondria in the brown and beige adipocytes play a key role in thermogenesis, as the site for uncoupling protein 1 (UCP1), which allows for the diffusion of protons through the mitochondrial inner membrane to produce heat. To support this energy demanding process, the mitochondria in brown and beige adipocytes increase oxidation of glucose, amino acids, and lipids. This review article explores the various mitochondria-produced and processed lipids that regulate thermogenesis including cardiolipins, free fatty acids, and acylcarnitines. These lipids play a number of roles in thermogenic adipose tissue including structural support of UCP1, transcriptional regulation, fuel source, and activation of cell signaling cascades.
Identifiants
pubmed: 33671745
pii: metabo11020124
doi: 10.3390/metabo11020124
pmc: PMC7926967
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : NIH HHS
ID : K12HD101368
Pays : United States
Organisme : NIA NIH HHS
ID : P30AG017266
Pays : United States
Organisme : NIH HHS
ID : P30DK020579
Pays : United States
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