The central moTOR of metabolism.
amino acids
lipids
mTOR
mTORC1
mTORC2
metabolism
protein
rapamycin
Journal
Developmental cell
ISSN: 1878-1551
Titre abrégé: Dev Cell
Pays: United States
ID NLM: 101120028
Informations de publication
Date de publication:
28 03 2022
28 03 2022
Historique:
received:
10
12
2021
revised:
20
02
2022
accepted:
24
02
2022
pubmed:
23
3
2022
medline:
15
4
2022
entrez:
22
3
2022
Statut:
ppublish
Résumé
The protein kinase mechanistic target of rapamycin (mTOR) functions as a central regulator of metabolism, integrating diverse nutritional and hormonal cues to control anabolic processes, organismal physiology, and even aging. This review discusses the current state of knowledge regarding the regulation of mTOR signaling and the metabolic regulation of the four macromolecular building blocks of the cell: carbohydrate, nucleic acid, lipid, and protein by mTOR. We review the role of mTOR in the control of organismal physiology and aging through its action in key tissues and discuss the potential for clinical translation of mTOR inhibition for the treatment and prevention of diseases of aging.
Identifiants
pubmed: 35316619
pii: S1534-5807(22)00126-5
doi: 10.1016/j.devcel.2022.02.024
pmc: PMC9004513
mid: NIHMS1791483
pii:
doi:
Substances chimiques
Mechanistic Target of Rapamycin Complex 1
EC 2.7.11.1
TOR Serine-Threonine Kinases
EC 2.7.11.1
Sirolimus
W36ZG6FT64
Types de publication
Journal Article
Review
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
691-706Subventions
Organisme : BLRD VA
ID : I01 BX004031
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG056771
Pays : United States
Organisme : NIAMS NIH HHS
ID : K12 AR084227
Pays : United States
Organisme : NIA NIH HHS
ID : R21 AG061635
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG062328
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK020579
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK125859
Pays : United States
Organisme : NICHD NIH HHS
ID : K12 HD101368
Pays : United States
Informations de copyright
Published by Elsevier Inc.
Déclaration de conflit d'intérêts
Declaration of interests D.W.L. has received funding from and is a scientific advisory board member of Aeovian Pharmaceuticals, which seeks to develop novel, selective mTOR inhibitors for the treatment of various diseases.
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