Ormdl3
beta cell
high fat diet
islet
knockout mouse
lipid
lipidomics
Journal
Frontiers in endocrinology
ISSN: 1664-2392
Titre abrégé: Front Endocrinol (Lausanne)
Pays: Switzerland
ID NLM: 101555782
Informations de publication
Date de publication:
2023
2023
Historique:
received:
20
02
2023
accepted:
31
03
2023
medline:
2
5
2023
pubmed:
1
5
2023
entrez:
1
5
2023
Statut:
epublish
Résumé
Chronic elevation of sphingolipids contributes to β-cell failure. ORMDL3 has been identified as a key regulator of sphingolipid homeostasis, however, its function in pancreatic β-cell pathophysiology remains unclear. Here, we generated a mouse model lacking
Identifiants
pubmed: 37124760
doi: 10.3389/fendo.2023.1170461
pmc: PMC10140491
doi:
Substances chimiques
ORMDL3 protein, mouse
0
Membrane Proteins
0
Glucose
IY9XDZ35W2
Ceramides
0
Insulin
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1170461Subventions
Organisme : NIDDK NIH HHS
ID : R01 DK133479
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM007215
Pays : United States
Organisme : NIDDK NIH HHS
ID : R56 DK128136
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK130919
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK020579
Pays : United States
Commentaires et corrections
Type : UpdateOf
Informations de copyright
Copyright © 2023 Hurley, Lee, Wade, Simcox and Engin.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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