Altered social recognition memory and hypothalamic neuropeptide expression in adolescent male and female rats following prenatal alcohol exposure and/or early-life adversity.
Adolescence
Early life adversity
Oxytocin
Prenatal alcohol exposure
Social behavior
Social recognition memory
Vasopressin
Journal
Psychoneuroendocrinology
ISSN: 1873-3360
Titre abrégé: Psychoneuroendocrinology
Pays: England
ID NLM: 7612148
Informations de publication
Date de publication:
04 2021
04 2021
Historique:
received:
08
09
2020
revised:
17
12
2020
accepted:
18
01
2021
pubmed:
1
2
2021
medline:
22
12
2021
entrez:
31
1
2021
Statut:
ppublish
Résumé
Prenatal alcohol exposure (PAE) and early-life adversity (ELA) both negatively impact social neurobehavioral development, including social recognition memory. Importantly, while individuals with PAE are more likely to experience ELA, relatively few studies have assessed the interaction of these two early insults on adolescent social behavior development. Here, we combine animal models of PAE and ELA to investigate both their unique and interactive effects on social neurobehavioral function in early and late adolescent male and female rats. Behavioral testing was followed by assessment of hypothalamic expression of oxytocin (OT) and vasopressin (AVP), key neuropeptides in the regulation of social behavior. Our results indicate that PAE and ELA have unique sex- and age-specific effects on social recognition memory and OT/AVP expression, with more pronounced neurobehavioral changes observed in males than in females in both early and late adolescence. Specifically, ELA impaired social recognition in early adolescent females regardless of prenatal treatment, while males showed deficits in both early and late adolescence in response to unique and interactive effects of PAE and ELA. Neurobiological data suggest that these perinatal insults differentially impact the OT and AVP systems in a sexually dimorphic manner, such that the OT system appears to be particularly sensitive to PAE in males while the AVP system appears to be more vulnerable to ELA in females. Taken together, our data provide novel insight into how the early postnatal environment may mediate outcomes of PAE as well as the power of animal models to interrogate the relationship between these pre- and postnatal insults.
Identifiants
pubmed: 33517167
pii: S0306-4530(21)00020-2
doi: 10.1016/j.psyneuen.2021.105146
pmc: PMC7969453
mid: NIHMS1668047
pii:
doi:
Substances chimiques
Ethanol
3K9958V90M
Oxytocin
50-56-6
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
105146Subventions
Organisme : NIAAA NIH HHS
ID : F31 AA023151
Pays : United States
Organisme : NIAAA NIH HHS
ID : R01 AA007789
Pays : United States
Organisme : NIAAA NIH HHS
ID : R01 AA022460
Pays : United States
Organisme : NIAAA NIH HHS
ID : R37 AA007789
Pays : United States
Informations de copyright
Copyright © 2021 Elsevier Ltd. All rights reserved.
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