Use of Testosterone in Postmenopausal Women.

Administration, Cutaneous Androgens Female Humans Libido Postmenopause Sexual Dysfunctions, Psychological / drug therapy Testosterone
Female sexual dysfunction Postmenopausal women Testosterone therapy

Journal

Endocrinology and metabolism clinics of North America
ISSN: 1558-4410
Titre abrégé: Endocrinol Metab Clin North Am
Pays: United States
ID NLM: 8800104

Informations de publication

Date de publication:
03 2021
Historique:
entrez: 1 2 2021
pubmed: 2 2 2021
medline: 26 10 2021
Statut: ppublish

Résumé

The role of testosterone in women and its potential as a therapeutic agent continue to attract controversy. The clinical trials of testosterone therapy for women primarily have focused on treatment of female sexual dysfunction, with the largest placebo-controlled studies being of transdermal testosterone in postmenopausal women. Based on the cumulative data from these studies, loss of sexual desire with associated personal distress currently is the only agreed-on indication for judicious testosterone supplementation for postmenopausal women. This article reviews the physiology of testosterone in women, summarizes the findings from observational studies and clinical trials, and considers indications for testosterone use.

Identifiants

DOI: 10.1016/j.ecl.2020.11.002 PMID: 33518180
pubmed: 33518180
pii: S0889-8529(20)30088-8
doi: 10.1016/j.ecl.2020.11.002
pii:
doi:

Substances chimiques

Androgens 0
Testosterone 3XMK78S47O

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

113-124

Informations de copyright

Copyright © 2020 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Disclosures Dr S.R. Davis reports having received honoraria from BioFemme, Besins Healthcare, and Pfizer Australia. She has also been a consultant to Mayne Pharmaceuticals, Lawley Pharmaceuticals, Roche Pharmaceuticals, Que Oncology, Abbott Pharmaceuticals, and Astellas Pharmaceuticals.

Auteurs

Susan R Davis (SR)

Women's Health Research Program, School of Public Health and Preventive Medicine, Monash University, 553 St Kilda Road, Melbourne, Victoria 3004, Australia. Electronic address: susan.davis@monash.edu.

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Classifications MeSH

questionsmedicales.fr › Thérapeutique › Traitement médicamenteux › Voies d'administration de substances chimiques et des médicaments › Administration par voie topique › Administration par voie cutanée › Use of Testosterone in Postmenopausal Women.
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Hormones, substituts d'hormones et antagonistes d'hormones › Hormones › Androgènes › Use of Testosterone in Postmenopausal Women.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Use of Testosterone in Postmenopausal Women.
questionsmedicales.fr › Phénomènes psychologiques › Théorie psychologique › Théorie psychanalytique › Libido › Use of Testosterone in Postmenopausal Women.
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Développement sexuel › Climatère › Ménopause › Post-ménopause › Use of Testosterone in Postmenopausal Women.
questionsmedicales.fr › Troubles mentaux › Dysfonctionnements sexuels psychogènes › Use of Testosterone in Postmenopausal Women.
questionsmedicales.fr › Hormones gonadiques › Hormones sexuelles stéroïdiennes › Congénères de la testostérone › Testostérone › Use of Testosterone in Postmenopausal Women.