Cortical connectivity of the nucleus basalis of Meynert in Parkinson's disease and Lewy body dementias.
DBS
DTI
MEG
coherence
oscillations
Journal
Brain : a journal of neurology
ISSN: 1460-2156
Titre abrégé: Brain
Pays: England
ID NLM: 0372537
Informations de publication
Date de publication:
12 04 2021
12 04 2021
Historique:
received:
26
07
2020
revised:
10
09
2020
accepted:
27
09
2020
pubmed:
2
2
2021
medline:
14
8
2021
entrez:
1
2
2021
Statut:
ppublish
Résumé
Parkinson's disease dementia (PDD) and dementia with Lewy bodies (DLB) are related conditions that are associated with cholinergic system dysfunction. Dysfunction of the nucleus basalis of Meynert (NBM), a basal forebrain structure that provides the dominant source of cortical cholinergic innervation, has been implicated in the pathogenesis of both PDD and DLB. Here we leverage the temporal resolution of magnetoencephalography with the spatial resolution of MRI tractography to explore the intersection of functional and structural connectivity of the NBM in a unique cohort of PDD and DLB patients undergoing deep brain stimulation of this structure. We observe that NBM-cortical structural and functional connectivity correlate within spatially and spectrally segregated networks including: (i) a beta band network to supplementary motor area, where activity in this region was found to drive activity in the NBM; (ii) a delta/theta band network to medial temporal lobe structures encompassing the parahippocampal gyrus; and (iii) a delta/theta band network to visual areas including lingual gyrus. These findings reveal functional networks of the NBM that are likely to subserve important roles in motor control, memory and visual function, respectively. Furthermore, they motivate future studies aimed at disentangling network contribution to disease phenotype.
Identifiants
pubmed: 33521808
pii: 6125159
doi: 10.1093/brain/awaa411
pmc: PMC8041337
mid: EMS115722
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
781-788Subventions
Organisme : Medical Research Council
ID : MK/K005464/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_12024/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_12024/5
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 203147
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/K022172/1
Pays : United Kingdom
Organisme : NINDS NIH HHS
ID : R01 NS023945
Pays : United States
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : NINDS NIH HHS
ID : RF1 NS023945
Pays : United States
Informations de copyright
© The Author(s) (2020). Published by Oxford University Press on behalf of the Guarantors of Brain.
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