Differential associations of APOE-ε2 and APOE-ε4 alleles with PET-measured amyloid-β and tau deposition in older individuals without dementia.

Aged Alleles Alzheimer Disease / diagnostic imaging Amyloid beta-Peptides / genetics Apolipoprotein E2 / genetics Apolipoprotein E4 / genetics Cross-Sectional Studies Genotype Humans Positron-Emission Tomography tau Proteins / genetics
APOE Amyloid-β Cognition Cross-sectional Hippocampal volumes Longitudinal PET Sex interaction Tau

Journal

European journal of nuclear medicine and molecular imaging
ISSN: 1619-7089
Titre abrégé: Eur J Nucl Med Mol Imaging
Pays: Germany
ID NLM: 101140988

Informations de publication

Date de publication:
07 2021
Historique:
received: 16 09 2020
accepted: 03 01 2021
pubmed: 2 2 2021
medline: 29 6 2021
entrez: 1 2 2021
Statut: ppublish

Résumé

To examine associations between the APOE-ε2 and APOE-ε4 alleles and core Alzheimer's disease (AD) pathological hallmarks as measured by amyloid-β (Aβ) and tau PET in older individuals without dementia. We analyzed data from 462 ADNI participants without dementia who underwent Aβ ([ Compared to APOE-ε3 homozygotes, APOE-ε2 carriers had lower global Aβ burden (β Our data suggest that the established protective effect of the APOE-ε2 allele against developing clinical AD is primarily linked to resistance against Aβ deposition rather than tau pathology.

Identifiants

DOI: 10.1007/s00259-021-05192-8 PMID: 33521872 PMC: PMC8175302
pubmed: 33521872
doi: 10.1007/s00259-021-05192-8
pii: 10.1007/s00259-021-05192-8
pmc: PMC8175302
doi:

Substances chimiques

Amyloid beta-Peptides 0
Apolipoprotein E2 0
Apolipoprotein E4 0
tau Proteins 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

2212-2224

Subventions

Organisme : Alzheimer Nederland (NL)
ID : WE.15-2019-10
Organisme : Instituto de Salud Carlos III
ID : CP19/00031
Organisme : Ministerio de Ciencia, Innovación y Universidades
ID : RYC-2013-13054
Organisme : Knut och Alice Wallenbergs Stiftelse (SE)
ID : KAW 2014.0363
Organisme : Swedish Research Council
ID : 2017-02869
Organisme : Swedish State
ID : ALFGBG-813971
Organisme : Swedish Alzheimer Foundation
ID : AF-740191
Organisme : NIA NIH HHS
ID : U01 AG024904
Pays : United States

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Auteurs

Gemma Salvadó (G)

Alzheimer Prevention Program, Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation, C/ Wellington, 30 08005, Barcelona, Spain. gsalvado@barcelonabeta.org.
IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain. gsalvado@barcelonabeta.org.
Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands. gsalvado@barcelonabeta.org.
ORCID: 0000-0002-5210-9230

Michel J Grothe (MJ)

Wallenberg Centre for Molecular and Translational Medicine, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden. mgrothe@us.es.
Unidad de Trastornos del Movimiento, Servicio de Neurología y Neurofisiología Clínica, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Avda. Manuel Siurot, s/n 41013, Seville, Spain. mgrothe@us.es.

Colin Groot (C)

Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands.

Alexis Moscoso (A)

Wallenberg Centre for Molecular and Translational Medicine, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden.

Michael Schöll (M)

Wallenberg Centre for Molecular and Translational Medicine, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden.
Dementia Research Centre, Institute of Neurology, University College London, London, UK.

Juan Domingo Gispert (JD)

Alzheimer Prevention Program, Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation, C/ Wellington, 30 08005, Barcelona, Spain.
IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain.
Universitat Pompeu Fabra, Barcelona, Spain.
Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Madrid, Spain.

Rik Ossenkoppele (R)

Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands.
Clinical Memory Research Unit, Lund University, Lund, Sweden.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Differential associations of APOE-ε2 and...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Gènes › Allèles › Differential associations of APOE-ε2 and...
questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Démence › Maladie d'Alzheimer › Differential associations of APOE-ε2 and...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Peptides bêta-amyloïdes › Differential associations of APOE-ε2 and...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Lipoprotéines › Apolipoprotéines › Apolipoprotéines E › Apolipoprotéine E2 › Differential associations of APOE-ε2 and...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Lipoprotéines › Apolipoprotéines › Apolipoprotéines E › Apolipoprotéine E4 › Differential associations of APOE-ε2 and...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études transversales › Differential associations of APOE-ε2 and...
questionsmedicales.fr › Phénomènes génétiques › Génotype › Differential associations of APOE-ε2 and...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Differential associations of APOE-ε2 and...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Techniques de diagnostic radioisotopique › Scintigraphie › Tomoscintigraphie › Tomographie par émission de positons › Differential associations of APOE-ε2 and...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de tissu nerveux › Protéines associées aux microtubules › Protéines tau › Differential associations of APOE-ε2 and...