High-intensity exercise and cognitive function in cognitively normal older adults: a pilot randomised clinical trial.

Aged Australia Cardiorespiratory Fitness Cognition Exercise Female Humans Male Pilot Projects
Cardiorespiratory fitness Cognition Dementia Exercise Genetics Intensity

Journal

Alzheimer's research & therapy
ISSN: 1758-9193
Titre abrégé: Alzheimers Res Ther
Pays: England
ID NLM: 101511643

Informations de publication

Date de publication:
01 02 2021
Historique:
received: 18 09 2020
accepted: 15 01 2021
entrez: 1 2 2021
pubmed: 2 2 2021
medline: 25 6 2021
Statut: epublish

Résumé

Physical inactivity has been consistently linked to increased risk of cognitive decline; however, studies examining the impact of exercise interventions on cognition have produced inconsistent findings. Some observational studies suggest exercise intensity may be important for inducing cognitive improvements; however, this has yet to be thoroughly examined in older adult cohorts. The objective of the current study was to evaluate the effect of systematically manipulated high-intensity and moderate-intensity exercise interventions on cognition. This multi-arm pilot randomised clinical trial investigated the effects of 6 months of high-intensity exercise and moderate-intensity exercise, compared with an inactive control, on cognition. Outcome measures were assessed at pre- (baseline), post- (6 months), and 12 months post-intervention. Ninety-nine cognitively normal men and women (aged 60-80 years) were enrolled from October 2016 to November 2017. Participants that were allocated to an exercise group (i.e. high-intensity or moderate-intensity) engaged in cycle-based exercise two times per week for 6 months. Cognition was assessed using a comprehensive neuropsychological test battery. Cardiorespiratory fitness was evaluated by a graded exercise test. There was a dose-dependent effect of exercise intensity on cardiorespiratory fitness, whereby the high-intensity group experienced greater increases in fitness than the moderate-intensity and control groups. However, there was no direct effect of exercise on cognition. We did not observe a direct effect of exercise on cognition. Future work in this field should be appropriately designed and powered to examine factors that may contribute to individual variability in response to intervention. This study is registered with the Australian New Zealand Clinical Trials Registry (ACTRN12617000643370). Registered on 3 May 2017-retrospectively registered. https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=372780.

Sections du résumé

BACKGROUND
Physical inactivity has been consistently linked to increased risk of cognitive decline; however, studies examining the impact of exercise interventions on cognition have produced inconsistent findings. Some observational studies suggest exercise intensity may be important for inducing cognitive improvements; however, this has yet to be thoroughly examined in older adult cohorts. The objective of the current study was to evaluate the effect of systematically manipulated high-intensity and moderate-intensity exercise interventions on cognition.
METHODS
This multi-arm pilot randomised clinical trial investigated the effects of 6 months of high-intensity exercise and moderate-intensity exercise, compared with an inactive control, on cognition. Outcome measures were assessed at pre- (baseline), post- (6 months), and 12 months post-intervention. Ninety-nine cognitively normal men and women (aged 60-80 years) were enrolled from October 2016 to November 2017. Participants that were allocated to an exercise group (i.e. high-intensity or moderate-intensity) engaged in cycle-based exercise two times per week for 6 months. Cognition was assessed using a comprehensive neuropsychological test battery. Cardiorespiratory fitness was evaluated by a graded exercise test.
RESULTS
There was a dose-dependent effect of exercise intensity on cardiorespiratory fitness, whereby the high-intensity group experienced greater increases in fitness than the moderate-intensity and control groups. However, there was no direct effect of exercise on cognition.
CONCLUSIONS
We did not observe a direct effect of exercise on cognition. Future work in this field should be appropriately designed and powered to examine factors that may contribute to individual variability in response to intervention.
TRIAL REGISTRATION
This study is registered with the Australian New Zealand Clinical Trials Registry (ACTRN12617000643370). Registered on 3 May 2017-retrospectively registered. https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=372780.

Identifiants

DOI: 10.1186/s13195-021-00774-y PMID: 33522961 PMC: PMC7849126
pubmed: 33522961
doi: 10.1186/s13195-021-00774-y
pii: 10.1186/s13195-021-00774-y
pmc: PMC7849126
doi:

Types de publication

Journal Article Randomized Controlled Trial Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

33

Subventions

Organisme : NIA NIH HHS
ID : P30 AG024827
Pays : United States

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Auteurs

Belinda M Brown (BM)

Discipline of Exercise Science, College of Science, Health, Engineering and Education, Murdoch University, 90 South Street, Murdoch, WA, 6150, Australia. b.brown@murdoch.edu.au.
Australian Alzheimer's Research Foundation, Sarich Neuroscience Research Institute, Nedlands, Western Australia, Australia. b.brown@murdoch.edu.au.
Centre for Healthy Ageing, Murdoch University, Murdoch, Western Australia, Australia. b.brown@murdoch.edu.au.
School of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia. b.brown@murdoch.edu.au.
ORCID: 0000-0001-7927-2540

Natalie Frost (N)

School of Psychological Science, University of Western Australia, Crawley, Western Australia, Australia.

Stephanie R Rainey-Smith (SR)

Australian Alzheimer's Research Foundation, Sarich Neuroscience Research Institute, Nedlands, Western Australia, Australia.
Centre for Healthy Ageing, Murdoch University, Murdoch, Western Australia, Australia.
School of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia.
School of Psychological Science, University of Western Australia, Crawley, Western Australia, Australia.

James Doecke (J)

Australian eHealth Research Centre, CSIRO, Brisbane, Queensland, Australia.
Department of Biomedical Sciences, Macquarie University, Sydney, New South Wales, Australia.

Shaun Markovic (S)

Discipline of Exercise Science, College of Science, Health, Engineering and Education, Murdoch University, 90 South Street, Murdoch, WA, 6150, Australia.
Australian Alzheimer's Research Foundation, Sarich Neuroscience Research Institute, Nedlands, Western Australia, Australia.

Nicole Gordon (N)

Discipline of Exercise Science, College of Science, Health, Engineering and Education, Murdoch University, 90 South Street, Murdoch, WA, 6150, Australia.

Michael Weinborn (M)

Australian Alzheimer's Research Foundation, Sarich Neuroscience Research Institute, Nedlands, Western Australia, Australia.
School of Psychological Science, University of Western Australia, Crawley, Western Australia, Australia.

Hamid R Sohrabi (HR)

Australian Alzheimer's Research Foundation, Sarich Neuroscience Research Institute, Nedlands, Western Australia, Australia.
Centre for Healthy Ageing, Murdoch University, Murdoch, Western Australia, Australia.
School of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia.
Department of Biomedical Sciences, Macquarie University, Sydney, New South Wales, Australia.

Simon M Laws (SM)

School of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia.
Collaborative Genomics and Translation Group, School of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia.
School of Pharmacy and Biomedical Sciences, Faculty of Health Sciences, Curtin Health Innovation Research Institute, Curtin University, Bentley, Western Australia, Australia.

Ralph N Martins (RN)

Australian Alzheimer's Research Foundation, Sarich Neuroscience Research Institute, Nedlands, Western Australia, Australia.
School of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia.
Department of Biomedical Sciences, Macquarie University, Sydney, New South Wales, Australia.

Kirk I Erickson (KI)

Discipline of Exercise Science, College of Science, Health, Engineering and Education, Murdoch University, 90 South Street, Murdoch, WA, 6150, Australia.
Department of Psychology, University of Pittsburgh, Pittsburgh, PA, USA.

Jeremiah J Peiffer (JJ)

Discipline of Exercise Science, College of Science, Health, Engineering and Education, Murdoch University, 90 South Street, Murdoch, WA, 6150, Australia.
Centre for Healthy Ageing, Murdoch University, Murdoch, Western Australia, Australia.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › High-intensity exercise and cognitive function...
questionsmedicales.fr › Régions géographiques › Océanie › Australasie › Australie › High-intensity exercise and cognitive function...
questionsmedicales.fr › Caractéristiques de la population › Santé › Aptitude physique › Capacité cardiorespiratoire › High-intensity exercise and cognitive function...
questionsmedicales.fr › Phénomènes psychologiques › Processus mentaux › Cognition › High-intensity exercise and cognitive function...
questionsmedicales.fr › Activités humaines › Exercice physique › High-intensity exercise and cognitive function...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › High-intensity exercise and cognitive function...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Projets pilotes › High-intensity exercise and cognitive function...