Femoral neck strain prediction during level walking using a combined musculoskeletal and finite element model approach.
Aged
Biomechanical Phenomena
Computer Simulation
Female
Femur
/ physiology
Femur Neck
/ metabolism
Finite Element Analysis
Forecasting
/ methods
Gait
/ physiology
Hip Joint
/ physiology
Humans
Lower Extremity
Magnetic Resonance Imaging
Middle Aged
Models, Biological
Muscle, Skeletal
/ physiology
Sprains and Strains
/ etiology
Stress, Mechanical
Tomography, X-Ray Computed
Walking
/ physiology
Weight-Bearing
/ physiology
Journal
PloS one
ISSN: 1932-6203
Titre abrégé: PLoS One
Pays: United States
ID NLM: 101285081
Informations de publication
Date de publication:
2021
2021
Historique:
received:
02
09
2020
accepted:
22
12
2020
entrez:
1
2
2021
pubmed:
2
2
2021
medline:
29
7
2021
Statut:
epublish
Résumé
Recently, coupled musculoskeletal-finite element modelling approaches have emerged as a way to investigate femoral neck loading during various daily activities. Combining personalised gait data with finite element models will not only allow us to study changes in motion/movement, but also their effects on critical internal structures, such as the femur. However, previous studies have been hampered by the small sample size and the lack of fully personalised data in order to construct the coupled model. Therefore, the aim of this study was to build a pipeline for a fully personalised multiscale (body-organ level) model to investigate the strain levels at the femoral neck during a normal gait cycle. Five postmenopausal women were included in this study. The CT and MRI scans of the lower limb, and gait data were collected for all participants. Muscle forces derived from the body level musculoskeletal models were used as boundary constraints on the finite element femur models. Principal strains were estimated at the femoral neck region during a full gait cycle. Considerable variation was found in the predicted peak strain among individuals with mean peak first principal strain of 0.24% ± 0.11% and mean third principal strain of -0.29% ± 0.24%. For four individuals, two overall peaks of the maximum strains were found to occur when both feet were in contact with the floor, while one individual had one peak at the toe-off phase. Both the joint contact forces and the muscular forces were found to substantially influence the loading at the femoral neck. A higher correlation was found between the predicted peak strains and the gluteus medius (R2 ranged between 0.95 and 0.99) than the hip joint contact forces (R2 ranged between 0.63 and 0.96). Therefore, the current findings suggest that personal variations are substantial, and hence it is important to consider multiple subjects before deriving general conclusions for a target population.
Identifiants
pubmed: 33524024
doi: 10.1371/journal.pone.0245121
pii: PONE-D-20-27617
pmc: PMC7850486
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0245121Subventions
Organisme : Medical Research Council
ID : MR/P020941/1
Pays : United Kingdom
Organisme : Department of Health
Pays : United Kingdom
Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
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