Role of Sphingosine 1-Phosphate Signalling Axis in Muscle Atrophy Induced by TNFα in C2C12 Myotubes.


Journal

International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791

Informations de publication

Date de publication:
28 Jan 2021
Historique:
received: 24 12 2020
revised: 19 01 2021
accepted: 25 01 2021
entrez: 2 2 2021
pubmed: 3 2 2021
medline: 9 9 2021
Statut: epublish

Résumé

Skeletal muscle atrophy is characterized by a decrease in muscle mass causing reduced agility, increased fatigability and higher risk of bone fractures. Inflammatory cytokines, such as tumor necrosis factor-alpha (TNFα), are strong inducers of skeletal muscle atrophy. The bioactive sphingolipid sphingosine 1-phoshate (S1P) plays an important role in skeletal muscle biology. S1P, generated by the phosphorylation of sphingosine catalyzed by sphingosine kinase (SK1/2), exerts most of its actions through its specific receptors, S1P

Identifiants

pubmed: 33525436
pii: ijms22031280
doi: 10.3390/ijms22031280
pmc: PMC7866171
pii:
doi:

Substances chimiques

Lysophospholipids 0
S1pr3 protein, mouse 0
Sphingosine-1-Phosphate Receptors 0
Tumor Necrosis Factor-alpha 0
sphingosine 1-phosphate 26993-30-6
Phosphotransferases (Alcohol Group Acceptor) EC 2.7.1.-
Sphk1 protein, mouse EC 2.7.1.-
sphingosine kinase 2, mouse EC 2.7.1.-
Sphingosine NGZ37HRE42

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Fondazione Cassa di Risparmio di Firenze
ID : 2018.1019 to Chiara Donati
Organisme : Università degli Studi di Firenze
ID : Fondi di Ateneo (ex 60%) to CD, PB, FC, CB
Organisme : Associazione Italiana per la Ricerca sul Cancro
ID : AIRC fellowship to VG

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Auteurs

Caterina Bernacchioni (C)

Department of Experimental and Clinical Biomedical Sciences "M. Serio", University of Florence, 50134 Florence, Italy.

Veronica Ghini (V)

Magnetic Resonance Center (CERM), University of Florence, 50019 Sesto Fiorentino, Italy.
Consorzio Interuniversitario Risonanze Magnetiche di Metallo Proteine (CIRMMP), 50019 Sesto Fiorentino, Italy.

Roberta Squecco (R)

Department of Experimental and Clinical Medicine, Section of Physiological Sciences, University of Florence, 50134 Florence, Italy.

Eglantina Idrizaj (E)

Department of Experimental and Clinical Medicine, Section of Physiological Sciences, University of Florence, 50134 Florence, Italy.

Rachele Garella (R)

Department of Experimental and Clinical Medicine, Section of Physiological Sciences, University of Florence, 50134 Florence, Italy.

Elisa Puliti (E)

Department of Experimental and Clinical Biomedical Sciences "M. Serio", University of Florence, 50134 Florence, Italy.

Francesca Cencetti (F)

Department of Experimental and Clinical Biomedical Sciences "M. Serio", University of Florence, 50134 Florence, Italy.

Paola Bruni (P)

Department of Experimental and Clinical Biomedical Sciences "M. Serio", University of Florence, 50134 Florence, Italy.

Chiara Donati (C)

Department of Experimental and Clinical Biomedical Sciences "M. Serio", University of Florence, 50134 Florence, Italy.

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Classifications MeSH