Exacerbated age-related hearing loss in mice lacking the p43 mitochondrial T3 receptor.
Age-related hearing loss
Mitochondrial dysfunction
Thyroid hormones
p43 mitochondrial T3 receptor
Journal
BMC biology
ISSN: 1741-7007
Titre abrégé: BMC Biol
Pays: England
ID NLM: 101190720
Informations de publication
Date de publication:
01 02 2021
01 02 2021
Historique:
received:
15
07
2020
accepted:
08
01
2021
entrez:
2
2
2021
pubmed:
3
2
2021
medline:
1
10
2021
Statut:
epublish
Résumé
Age-related hearing loss (ARHL), also known as presbycusis, is the most common sensory impairment seen in elderly people. However, the cochlear aging process does not affect people uniformly, suggesting that both genetic and environmental (e.g., noise, ototoxic drugs) factors and their interaction may influence the onset and severity of ARHL. Considering the potential links between thyroid hormone, mitochondrial activity, and hearing, here, we probed the role of p43, a N-terminally truncated and ligand-binding form of the nuclear receptor TRα1, in hearing function and in the maintenance of hearing during aging in p43 We found that the p43 These results demonstrate for the first time a requirement for p43 in the maintenance of hearing during aging and highlight the need to probe the potential link between human THRA gene polymorphisms and/or mutations and accelerated age-related deafness or some adult-onset syndromic deafness.
Sections du résumé
BACKGROUND
Age-related hearing loss (ARHL), also known as presbycusis, is the most common sensory impairment seen in elderly people. However, the cochlear aging process does not affect people uniformly, suggesting that both genetic and environmental (e.g., noise, ototoxic drugs) factors and their interaction may influence the onset and severity of ARHL. Considering the potential links between thyroid hormone, mitochondrial activity, and hearing, here, we probed the role of p43, a N-terminally truncated and ligand-binding form of the nuclear receptor TRα1, in hearing function and in the maintenance of hearing during aging in p43
RESULTS
We found that the p43
CONCLUSIONS
These results demonstrate for the first time a requirement for p43 in the maintenance of hearing during aging and highlight the need to probe the potential link between human THRA gene polymorphisms and/or mutations and accelerated age-related deafness or some adult-onset syndromic deafness.
Identifiants
pubmed: 33526032
doi: 10.1186/s12915-021-00953-1
pii: 10.1186/s12915-021-00953-1
pmc: PMC7852282
doi:
Substances chimiques
Receptors, Thyroid Hormone
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
18Subventions
Organisme : Labex EpiGenMed
ID : ANR-10-LABX-12-01
Organisme : Fondation de l'Avenir pour la Recherche Médicale Appliquée
ID : Et2-675
Organisme : Fondation Gueules Cassées
ID : 77-2017
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