Host-Derived Matrix Metalloproteinase-13 Activity Promotes Multiple Myeloma-Induced Osteolysis and Reduces Overall Survival.
Animals
Cell Differentiation
/ genetics
Cell Line, Tumor
Chemokines, CXC
/ metabolism
Disease Models, Animal
Disease Progression
Female
Humans
Male
Matrix Metalloproteinase 13
/ genetics
Mesenchymal Stem Cells
/ metabolism
Mice
Mice, Inbred C57BL
Mice, Transgenic
Multiple Myeloma
/ genetics
Osteoblasts
/ metabolism
Osteoclasts
/ metabolism
Osteogenesis
/ genetics
Osteolysis
/ genetics
Signal Transduction
/ genetics
Survival Rate
Journal
Cancer research
ISSN: 1538-7445
Titre abrégé: Cancer Res
Pays: United States
ID NLM: 2984705R
Informations de publication
Date de publication:
01 05 2021
01 05 2021
Historique:
received:
12
08
2020
revised:
02
12
2020
accepted:
25
01
2021
pubmed:
3
2
2021
medline:
18
9
2021
entrez:
2
2
2021
Statut:
ppublish
Résumé
Multiple myeloma promotes systemic skeletal bone disease that greatly contributes to patient morbidity. Resorption of type I collagen-rich bone matrix by activated osteoclasts results in the release of sequestered growth factors that can drive progression of the disease. Matrix metalloproteinase-13 (MMP13) is a collagenase expressed predominantly in the skeleton by mesenchymal stromal cells (MSC) and MSC-derived osteoblasts. Histochemical analysis of human multiple myeloma specimens also demonstrated that MMP13 largely localizes to the stromal compartment compared with CD138
Identifiants
pubmed: 33526510
pii: 0008-5472.CAN-20-2705
doi: 10.1158/0008-5472.CAN-20-2705
pmc: PMC8809361
mid: NIHMS1669661
doi:
Substances chimiques
Chemokines, CXC
0
Cxcl7 protein, mouse
0
MMP13 protein, human
EC 3.4.24.-
Matrix Metalloproteinase 13
EC 3.4.24.-
Mmp13 protein, mouse
EC 3.4.24.-
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
2415-2428Subventions
Organisme : NCI NIH HHS
ID : R01 CA239214
Pays : United States
Organisme : NCI NIH HHS
ID : R21 CA191981
Pays : United States
Informations de copyright
©2021 American Association for Cancer Research.
Références
Dis Model Mech. 2009 Nov-Dec;2(11-12):604-11
pubmed: 19779066
J Biol Chem. 2006 Nov 3;281(44):33814-24
pubmed: 16959767
Gastroenterology. 2006 Jan;130(1):127-36
pubmed: 16401476
J Biol Chem. 1996 Jan 19;271(3):1544-50
pubmed: 8576151
J Cell Physiol. 2004 Jul;200(1):11-9
pubmed: 15137053
Bone. 2011 Jan;48(1):44-53
pubmed: 20601294
J Bone Miner Res. 2012 Sep;27(9):1936-50
pubmed: 22549931
Hum Mol Genet. 2007 May 1;16(9):1113-23
pubmed: 17400654
Biosci Biotechnol Biochem. 2016 Nov;80(11):2122-2131
pubmed: 27362887
Stem Cells Int. 2018 Mar 22;2018:6869128
pubmed: 29765418
Biochim Biophys Acta. 2010 Jan;1803(1):121-32
pubmed: 19616584
APMIS. 1999 Jan;107(1):45-53
pubmed: 10190279
J Biol Chem. 1996 May 24;271(21):12517-24
pubmed: 8647860
Oncotarget. 2014 Sep 30;5(18):8284-305
pubmed: 25268740
Nat Rev Clin Oncol. 2012 Jan 10;9(2):110-8
pubmed: 22231759
Matrix Biol. 2015 May-Jul;44-46:200-6
pubmed: 25652204
Dis Model Mech. 2013 Mar;6(2):397-403
pubmed: 22917927
J Bone Miner Res. 2003 Mar;18(3):482-92
pubmed: 12619933
Exp Cell Res. 2002 Sep 10;279(1):1-13
pubmed: 12213208
Crit Rev Biochem Mol Biol. 2002;37(3):149-66
pubmed: 12139441
Bone. 2004 Jan;34(1):48-56
pubmed: 14751562
J Immunol. 2002 Sep 1;169(5):2602-10
pubmed: 12193731
Oncogene. 2017 Aug;36(31):4498-4507
pubmed: 28368420
PLoS One. 2018 May 21;13(5):e0196204
pubmed: 29782494
J Mol Med (Berl). 2016 Jan;94(1):21-35
pubmed: 26423531
Dev Cell. 2010 Jan 19;18(1):77-89
pubmed: 20152179
Oncotarget. 2018 Apr 13;9(28):20119-20133
pubmed: 29732008
Breast Cancer Res. 2011 Oct 27;13(5):R105
pubmed: 22032644
J Mol Biol. 1999 Oct 1;292(4):837-44
pubmed: 10525409
Data Brief. 2016 Feb 22;7:299-310
pubmed: 26981551
Bioorg Med Chem. 2018 Oct 1;26(18):4984-4995
pubmed: 30249495
J Bone Miner Res. 2003 May;18(5):859-67
pubmed: 12733725
BMC Cancer. 2008 Mar 28;8:83
pubmed: 18373849
Mol Cancer. 2017 Feb 28;16(1):49
pubmed: 28241871
Contemp Oncol (Pozn). 2016;20(3):225-8
pubmed: 27647987
Cancer Cell. 2005 May;7(5):485-96
pubmed: 15894268
Arterioscler Thromb Vasc Biol. 2008 Nov;28(11):1920-7
pubmed: 18723831
PLoS One. 2012;7(1):e29615
pubmed: 22253746
J Biol Chem. 1996 Jan 26;271(4):2126-32
pubmed: 8567669
Development. 2004 Dec;131(23):5883-95
pubmed: 15539485
Elife. 2015 Sep 21;4:e09345
pubmed: 26390284
Exp Hematol. 2004 Nov;32(11):1064-72
pubmed: 15539084
Am J Pathol. 1999 Feb;154(2):469-80
pubmed: 10027405
J Pathol. 2001 Jun;194(2):217-24
pubmed: 11400151
Proc Natl Acad Sci U S A. 2004 Dec 7;101(49):17192-7
pubmed: 15563592
J Clin Invest. 2016 May 2;126(5):1759-72
pubmed: 27043283
Semin Hematol. 2004 Apr;41(2 Suppl 4):1-5
pubmed: 15190509
Blood. 2004 Oct 1;104(7):2149-54
pubmed: 15138161
Biochemistry. 2015 May 19;54(19):3110-21
pubmed: 25897652
J Biol Chem. 2011 Sep 30;286(39):34271-85
pubmed: 21784845
Matrix Biol. 2016 Dec;56:57-73
pubmed: 27084377
Stem Cells. 2016 Nov;34(11):2733-2743
pubmed: 27339271
J Cell Sci. 1995 Dec;108 ( Pt 12):3649-59
pubmed: 8719871
Nat Protoc. 2010 Mar;5(3):550-60
pubmed: 20203670
J Med Chem. 2017 Jul 13;60(13):5816-5825
pubmed: 28653849
Anticancer Res. 2010 Dec;30(12):5029-36
pubmed: 21187486
Immunity. 2015 Jul 21;43(1):200-9
pubmed: 26163370
J Biol Chem. 2012 Nov 9;287(46):38716-28
pubmed: 22992737
J Enzyme Inhib Med Chem. 2018 Dec;33(1):890-904
pubmed: 29723068
Leukemia. 2018 Jan;32(1):176-183
pubmed: 28626216
Matrix Biol. 2015 May-Jul;44-46:239-46
pubmed: 25595836
Am J Pathol. 2009 Aug;175(2):533-46
pubmed: 19590036
J Biol Chem. 1987 May 5;262(13):6221-6
pubmed: 3032960