Kaiso (ZBTB33) subcellular partitioning functionally links LC3A/B, the tumor microenvironment, and breast cancer survival.
Automation, Laboratory
Breast Neoplasms
/ genetics
Cell Line, Tumor
Female
Fluorescent Antibody Technique
Gene Expression Regulation, Neoplastic
Humans
Image Interpretation, Computer-Assisted
Microscopy, Fluorescence
Microtubule-Associated Proteins
/ genetics
Prognosis
Retrospective Studies
Risk Assessment
Risk Factors
Signal Transduction
Time Factors
Tissue Array Analysis
Transcription Factors
/ genetics
Tumor Escape
Tumor Microenvironment
United States
/ epidemiology
Journal
Communications biology
ISSN: 2399-3642
Titre abrégé: Commun Biol
Pays: England
ID NLM: 101719179
Informations de publication
Date de publication:
01 02 2021
01 02 2021
Historique:
received:
28
02
2020
accepted:
29
12
2020
entrez:
2
2
2021
pubmed:
3
2
2021
medline:
10
8
2021
Statut:
epublish
Résumé
The use of digital pathology for the histomorphologic profiling of pathological specimens is expanding the precision and specificity of quantitative tissue analysis at an unprecedented scale; thus, enabling the discovery of new and functionally relevant histological features of both predictive and prognostic significance. In this study, we apply quantitative automated image processing and computational methods to profile the subcellular distribution of the multi-functional transcriptional regulator, Kaiso (ZBTB33), in the tumors of a large racially diverse breast cancer cohort from a designated health disparities region in the United States. Multiplex multivariate analysis of the association of Kaiso's subcellular distribution with other breast cancer biomarkers reveals novel functional and predictive linkages between Kaiso and the autophagy-related proteins, LC3A/B, that are associated with features of the tumor immune microenvironment, survival, and race. These findings identify effective modalities of Kaiso biomarker assessment and uncover unanticipated insights into Kaiso's role in breast cancer progression.
Identifiants
pubmed: 33526872
doi: 10.1038/s42003-021-01651-y
pii: 10.1038/s42003-021-01651-y
pmc: PMC7851134
doi:
Substances chimiques
MAP1LC3A protein, human
0
MAP1LC3B protein, human
0
Microtubule-Associated Proteins
0
Transcription Factors
0
ZBTB33 protein, human
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
150Subventions
Organisme : NCI NIH HHS
ID : U54 CA118623
Pays : United States
Organisme : NIMHD NIH HHS
ID : U54 MD007585
Pays : United States
Organisme : NIGMS NIH HHS
ID : U54 GM128729
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA253368
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA013696
Pays : United States
Références
Cancer Res. 2005 Dec 15;65(24):11259-64
pubmed: 16357129
Autophagy. 2018;14(6):1060-1071
pubmed: 29909716
Hum Pathol. 2018 Oct;80:219-230
pubmed: 29902578
Breast Cancer Res. 2001;3(5):289-93
pubmed: 11597316
Bioinformatics. 2013 Jan 1;29(1):15-21
pubmed: 23104886
Methods Enzymol. 2006;410:400-15
pubmed: 16938563
Bioinformatics. 2006 Jun 15;22(12):1540-2
pubmed: 16595560
Nat Commun. 2018 Mar 13;9(1):1059
pubmed: 29535312
J Natl Cancer Inst. 2019 Jan 1;111(1):99-100
pubmed: 30307580
PLoS One. 2012;7(5):e37864
pubmed: 22662240
Nat Commun. 2017 Sep 19;8(1):592
pubmed: 28928380
Am J Clin Pathol. 2017 Aug 1;148(2):108-118
pubmed: 28898983
Proc Natl Acad Sci U S A. 2019 Dec 11;:
pubmed: 31826955
Clin Cancer Res. 2020 Apr 15;26(8):1905-1914
pubmed: 31911546
Proc Natl Acad Sci U S A. 2016 Oct 25;113(43):E6600-E6609
pubmed: 27791031
Cancer Metastasis Rev. 2016 Dec;35(4):575-588
pubmed: 27913999
PLoS One. 2011 Mar 21;6(3):e17911
pubmed: 21445301
Am J Epidemiol. 2004 Dec 1;160(11):1033-8
pubmed: 15561982
Autophagy. 2014 May;10(5):913-25
pubmed: 24589857
Biochim Biophys Acta. 2007 Jan;1773(1):59-68
pubmed: 17050009
J Clin Lab Anal. 2009;23(4):249-58
pubmed: 19623642
EMBO J. 2015 Apr 1;34(7):856-80
pubmed: 25712477
Int J Cancer. 2014 Mar 15;134(6):1408-21
pubmed: 23996684
Genome Biol. 2013 Feb 14;14(2):R12
pubmed: 23409703
Clin Breast Cancer. 2016 Feb;16(1):51-8
pubmed: 26364145
Cancer. 2018 Aug;124(16):3307-3318
pubmed: 29671878
Cancer Lett. 2016 Oct 1;380(2):513-22
pubmed: 27424525
Cell Rep. 2016 May 24;15(8):1660-72
pubmed: 27184837
Cancer Res. 2012 Mar 15;72(6):1321-31
pubmed: 22422988
Nat Commun. 2013;4:1449
pubmed: 23385593
Biochim Biophys Acta Rev Cancer. 2019 Jan;1871(1):64-74
pubmed: 30419310
Cancers (Basel). 2020 May 13;12(5):
pubmed: 32414099
Genome Res. 2010 Sep;20(9):1297-303
pubmed: 20644199
Proc Natl Acad Sci U S A. 2019 Mar 5;116(10):4326-4335
pubmed: 30770442
Bioinformatics. 2004 Feb 12;20(3):307-15
pubmed: 14960456
Cell Cycle. 2009 Jul 15;8(14):2303-4
pubmed: 19502788
Bioinformatics. 2011 Jun 15;27(12):1739-40
pubmed: 21546393
Cancer Cell. 2003 Apr;3(4):307-10
pubmed: 12726856
Cancer Epidemiol Biomarkers Prev. 2018 Mar;27(3):321-330
pubmed: 29339359
Proc Natl Acad Sci U S A. 2019 Feb 26;116(9):3678-3687
pubmed: 30733298
Nat Commun. 2018 Jul 26;9(1):2921
pubmed: 30050132
Epigenetics Chromatin. 2013 May 21;6(1):13
pubmed: 23693142
Oncotarget. 2016 Jun 28;7(26):39544-39555
pubmed: 27250032
Nucleic Acids Res. 2015 Apr 20;43(7):e47
pubmed: 25605792
Nat Biotechnol. 2012 Feb 12;30(3):253-60
pubmed: 22327324
CA Cancer J Clin. 2019 Jan;69(1):7-34
pubmed: 30620402
Mod Pathol. 2018 Oct;31(10):1539-1552
pubmed: 29849114
Curr Opin Cell Biol. 2015 Aug;35:106-16
pubmed: 25988755
Methods Mol Biol. 2019;1854:209-222
pubmed: 29855817
Curr Pharm Des. 2014;20(30):4879-98
pubmed: 24283956
Small GTPases. 2018 May 4;9(3):260-273
pubmed: 27574848
Eur J Histochem. 2015 May 05;59(2):2481
pubmed: 26150155
Cancer Causes Control. 2017 Nov;28(11):1295-1304
pubmed: 28887687
Methods Mol Biol. 2017;1560:189-194
pubmed: 28155154
Nucleic Acids Res. 2011 Jan;39(Database issue):D986-90
pubmed: 20972215
J Mammary Gland Biol Neoplasia. 2011 Sep;16(3):173-87
pubmed: 21779879
Nat Genet. 2011 May;43(5):491-8
pubmed: 21478889
Expert Rev Anticancer Ther. 2011 Aug;11(8):1283-94
pubmed: 21916582
Autophagy. 2014 Mar;10(3):526-8
pubmed: 24413059
Front Pharmacol. 2018 May 22;9:536
pubmed: 29910728
Genes Dev. 2018 Sep 1;32(17-18):1141-1154
pubmed: 30181360
Nat Rev Genet. 2014 Jun;15(6):379-93
pubmed: 24776769
Clin Exp Metastasis. 2014 Jun;31(5):497-510
pubmed: 24570268
PLoS Genet. 2018 Jun 7;14(6):e1007368
pubmed: 29879116
Adv Cancer Res. 2016;130:1-53
pubmed: 27037750
Clin Breast Cancer. 2010;10 Suppl 1:E38-46
pubmed: 20587406
Am J Hum Genet. 2016 Jan 7;98(1):5-21
pubmed: 26748513
Nat Genet. 2012 Nov;44(11):1176-7
pubmed: 23104063
Genes Dev. 2001 Jul 1;15(13):1613-8
pubmed: 11445535
Methods Mol Biol. 2014;1150:153-60
pubmed: 24743996
Proc Natl Acad Sci U S A. 2005 Oct 25;102(43):15545-50
pubmed: 16199517
J Cell Biol. 2020 Jan 6;219(1):
pubmed: 31753861
Nat Commun. 2019 Nov 29;10(1):5440
pubmed: 31784511
Nat Cell Biol. 2020 Feb;22(2):137-139
pubmed: 31992866
Nature. 2015 Oct 1;526(7571):68-74
pubmed: 26432245
Nat Cell Biol. 2020 Feb;22(2):187-199
pubmed: 31932738
Histochem Cell Biol. 2015 Jan;143(1):29-43
pubmed: 25182933
Genome Res. 2009 Sep;19(9):1655-64
pubmed: 19648217
Autophagy. 2019 Oct;15(10):1682-1693
pubmed: 30894055
Nat Rev Mol Cell Biol. 2015 Aug;16(8):461-72
pubmed: 26177004
BMC Cancer. 2009 Jun 09;9:178
pubmed: 19508730
J Med Genet. 2018 Jul;55(7):431-441
pubmed: 29929997
Cancer Res. 2005 Mar 15;65(6):2224-33
pubmed: 15781635
Nat Rev Clin Oncol. 2016 Apr;13(4):228-41
pubmed: 26667975
Cancer Res Treat. 2019 Apr;51(2):649-663
pubmed: 30064200