Occurrence and severity of acute respiratory infections during the first year among very preterm infants: an Epipage-2 cohort analysis.
Acute respiratory infections
Bronchiolitis
Oxygen
Palivizumab
Preterm
Journal
European journal of pediatrics
ISSN: 1432-1076
Titre abrégé: Eur J Pediatr
Pays: Germany
ID NLM: 7603873
Informations de publication
Date de publication:
Jun 2021
Jun 2021
Historique:
received:
20
11
2020
accepted:
18
01
2021
revised:
15
01
2021
pubmed:
3
2
2021
medline:
24
6
2021
entrez:
2
2
2021
Statut:
ppublish
Résumé
This study aims to describe the incidence of acute respiratory infections (ARI) during the first year in infants born before 32 weeks' gestation, and to analyze and study the risk factors as well as factors associated with oxygen requirement among infants with an ARI, in the palivizumab era. This study included 2571 infants from a nationwide French population-based cohort (Epipage 2). ARI at 1-year corrected age was identified by parental questionnaires. Risk and severity factors included those already known, and detailed information about neonatal morbidities. ARI occurred in 52.2% (n = 1349) of infants. Oxygen therapy was used in 33.2% (n = 391) of infants with an ARI. Risk factors for AII were male sex, bronchopulmonary dysplasia, presence of siblings at home, and childcare in the community together with incomplete treatment palivizumab. Mechanical ventilation in the neonatal period, bronchopulmonary dysplasia, and discharge between October and March were associated with more frequent oxygen requirement. No other factors describing neonatal morbidities were associated with risk of ARI or oxygen requirement.Conclusion: ARIs are still very common during the first year of life of very preterm children, and oxygen therapy is frequently needed. Educational strategies are needed in all families with a very preterm infant. What is Known: • Acute respiratory infections (ARIs) are the first cause of rehospitalizations in preterm children, with bronchopulmonary dysplasia being the main risk factor. • Palivizumab prophylaxis has proven its effect against severe RSV infections, but it is not universal. What is New: • No factor describing neonatal morbidity, except BPD, was associated with ARI occurrence or severity. • BPD and discharge during RSV season were the only factors associated with O
Identifiants
pubmed: 33527179
doi: 10.1007/s00431-021-03956-w
pii: 10.1007/s00431-021-03956-w
doi:
Substances chimiques
Antiviral Agents
0
Palivizumab
DQ448MW7KS
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1833-1840Subventions
Organisme : French Equipex Program of Investments in the Future
ID : ANR-11-AQPX-0038
Références
Smyth RL, Openshaw PJ (2006) Bronchiolitis. Lancet 368:312–322
doi: 10.1016/S0140-6736(06)69077-6
Murray J, Bottle A, Sharland M, Modi N, Aylin P, Majeed A, Saxena S, on behalf of the Medecines for Neonates Investigator Group (2014) Risk factors for hospital admission with RSV bronchiolitis in England: a population-based birth cohort study. PLoS One 9:e89186
doi: 10.1371/journal.pone.0089186
Hong T, Bolisetty S, Bajuk B, Abdel-Latif M, Oei J, Daffe A, Lui K (2016) A population study of respiratory rehospitalisation in very preterm infants in the first 3 years of life. J Pediatr Child Health 52:715–721
doi: 10.1111/jpc.13205
Laugier O, Garcia P, Boucékine M, Daguzan A, Tardieu S, Sambuc R, Boubred F (2017) Influence of socioeconomic context on the rehospitalization rates of infants born preterm. J Pediatr 190:174–179
doi: 10.1016/j.jpeds.2017.08.001
Liese JG, Grill E, Fischer B, Roeckl-Wiedmann J, Carr D, Belohradsky BH, The Munich RSV Study Group (2003) Incidence and risk factors of respiratory syncytial virus-related hospitalizations in premature infants in Germany. Eur J Pediatr 162:230–236
doi: 10.1007/s00431-002-1105-7
Gijtenbeek RG, Kerstjens JM, Reijneveld SA, Duiverman EJ, Bos AF, Vrijlandt EJ (2015) RSV infection among children born moderately preterm in a community-based cohort. Eur J Pediatr 174:435–442
doi: 10.1007/s00431-014-2415-2
Gouyon JB, Rozé JC, Guillermet-Fromentin C, Glorieux I, Adamon L, Di Maio M, Miloradovitch T, Anghelscu D, Pinquier D, Escande B, Elleau C (2013) Hospitalizations for respiratory syncytial virus bronchiolitis in preterm infants at < 33 weeks gestation without bronchopulmonary dysplasia: the CASTOR study. Epidemiol Infect 141:816–826
doi: 10.1017/S0950268812001069
Resch B, Pasnocht A, Gusenleitner W, Müller W (2005) Rehospitalisations for respiratory disease and respiratory syncytial virus infection in preterm infants of 29-36 weeks gestational age. J Infect 50:397–403
doi: 10.1016/j.jinf.2004.06.015
Paes B, Fauroux B, Figueras-Aloy J, Bont L, Checchia PA, Simoes EAF, Manzoni P, Carbonell-Estrany X. Defining the risk and associated morbitidy and mortality of severe respiratory syncytial virus infection
Straak Z, Saliba E, Kosma P, Posfay-Barbe K, Yunis K, Farstad T, Unnebrink K, van Wyk J, Wegzyn C, Notario G, Kalus S, Campbell FJ (2016) Predictors of RSV LRTI hospitalization in infants born at 33 to 35 weeks gestational age: a large multinational study (PONI). PLoS One:e0157446
Haute Autorité de Santé [homepage on the internet]. Paris. Pertinence du recours à l'hospitalisation pour bronchiolite. [updated 2011 Sep 01; cited 2020 March 11]. Available from: https://www.has-sante.fr/upload/docs/application/pdf/2013-04/pertinence_du_recours_a_lhospitalisation_pour_bronchiolite.pdf
Torchin H, Rousseau J, Marchand-Martin L, Truffert P, Jarreau PH, Ancel PY (2018) Palivizumab administration in preterm infants in France: EPIPAGE-2 cohort study. Arch Pediatr 25:89–94
doi: 10.1016/j.arcped.2017.12.009
Haute Autorité de Santé [homepage on the internet]. Paris. Commission de la transparence, avis, 19 décembre 2007. [cited 2020 October 10]. Available from: https://www.has-sante.fr/upload/docs/application/pdf/ct-5014_synagis.pdf
Ancel PY, Goffinet F (2014) EPIPAGE 2 Writing Group. EPIPAGE 2: a preterm birth cohort in France in 2011. BMC Pediatr 14:97
doi: 10.1186/1471-2431-14-97
Ego A, Prunet C, Blondel B, Kaminski M, Goffinet F, Zeitlin J (2016) Customized and non-customized French intrauterine growth curves. II - compariton with existing curves and benefits of customization. J Gynecol Obstet Biol Reprod 45:165–176
doi: 10.1016/j.jgyn.2015.08.008
Jobe AH, Bancalari E (2001) Bronchopulmonary dysplasia. Am J Respir Crit Care Med 163:1723–1729
doi: 10.1164/ajrccm.163.7.2011060
Sauzet O, Peacock JL (2017) Binomial outcomes in dataset with some clusters of size two: can the dependence of twins be accounted for? A simulation study comparing the reliability of statistical methods based on a dataset of preterm infants. BMC Med Res Methodol 17:110
doi: 10.1186/s12874-017-0369-6
Pérez-Yarza EG, Moreno-Galdo A, Ramilo O, Rubi T, Escribano A, Torres A, Sardon O, Oliva C, Pérez G, Cortell I, Rovira-Amigo S, Pastor-Vierao MS, Périz-Frias J, Velasco V, Torres-Borrego J, Figuerola J, Marrio MI, Garcia-Henrnandez G, Mejias A, on behalf of the SAREPREM 3235 investigators (2017) Risk factors for bronchiolitis, recurrent wheezing, and related hospitalization in preterm infants during the first year of life. Pediatr Allergy Immunol 2015:26:707–804. 19. S Iacobelli et al. Gestational age and 1-year hospital admission or mortality: a nation-wide population-based study. BMC Pediatr 17:28
doi: 10.1186/s12887-017-0787-y
Iacobelli S, Combier E, Roussot A, Cottenet J, Gouyon JB, Quantin C (2017) Gestational age and 1-year hospital admission or mortality: a nation-wide population-based study. BMC Pediatr 17:28
doi: 10.1186/s12887-017-0787-y
Olabarieta I, Gonzales-Carrasco E, Calvo C, Pozo F, Casas I, Garcia-Garcia ML (2015) Hospital admission due to respiratory viral infections in moderate preterm, late preterm and term infants during their first year of life. Allergol Immunopathol (Madr) 43:468–473
doi: 10.1016/j.aller.2014.06.006
Resch B, Egger B, Kurath-Koller S, Urlesberger B (2017) Respiratory syncytial virus hospitalizations in infants of 28 weeks gestational age and less in the palivizumab era. Int J Infect Dis 57:50–53
doi: 10.1016/j.ijid.2017.01.034
Blanken MO, Paes B, Anderson EJ, Lanari M, Sheridan-Pereira M, Buchan S, Fullbarton JR, ElizaBeth G, Notario G, Rodgers-Gray BS, Carbonell-Estrany X (2018) Risk scoring tool to predict respiratory syncytial virus hospitalisation in premature infants. Pediatr Pulmonol 53:605–612
doi: 10.1002/ppul.23960
Torchin H, Charkaluk ML, Rousseau J, Marchand-Martin L, Treluyer L, Nuytten A, Truffert P, Jarreau PH, Ancel PY (2020) Full compliance with respiratory syncitial virus prophylaxis was associated with fewer respiratory related hospital admissions in preterm children: a cohort study. Acta Paediatr online ahead of print
Bernard L, Lecomte B, Pereira B, Proux A, Boyer A, Sautou V (2015) Impact of a targeted educational intervention on respiratory syncytial virus bronchiolitis prevention in full-term and preterm infants. Arch Pediatr 22:146–153
doi: 10.1016/j.arcped.2014.11.015
Garcia CG, Bhore R, Soriano-Fallas A, Trost M, Chason R, Ramilo O, Mejias A (2010) Risk factors in children hospitalized with RSV bronchiolitis versus non-RSV bronchiolitis. Pediatrics 126:e1453–e1460
doi: 10.1542/peds.2010-0507
Ciuffini F, Robertson CF, Tingay DG (2018) How best to capture the respiratory consequences of prematurity? Eur Respir Rev 14:170108
doi: 10.1183/16000617.0108-2017
Mecklin M, Heikkila P, Korppi M (2017) Low age, low birthweight and congenital heart disease are risk factors for intensive care in infants with bronchiolitis. Acta Paediatr 106:2004–2010
doi: 10.1111/apa.14021
Munoz-Quiles C, Lopez-Lacort M, Ubeda-Sansano I, Aleman-Sanchez S, Pérez-Vilar S, Puig-Barbera J, Diez-Comingo J (2016) Population-based analysis of bronchiolitis epidemiolgy in Valencia, Spain. Pediatr Infect J 35:275–280
doi: 10.1097/INF.0000000000000993