Mitochondrial translation deficiency impairs NAD
Animals
Cells, Cultured
Glyceraldehyde-3-Phosphate Dehydrogenase (Phosphorylating)
/ metabolism
Hypoxia-Inducible Factor 1, alpha Subunit
/ metabolism
Lysosomes
/ metabolism
Mice
Mice, Inbred C57BL
Microtubule-Associated Proteins
/ metabolism
Mitochondria, Heart
/ metabolism
Mitochondrial Proteins
/ deficiency
NAD
/ metabolism
Nicotinamide-Nucleotide Adenylyltransferase
/ metabolism
Phosphoglycerate Kinase
/ metabolism
GAPDH
NAD+
Nmnat3
lysosome
mitochondria
Journal
The EMBO journal
ISSN: 1460-2075
Titre abrégé: EMBO J
Pays: England
ID NLM: 8208664
Informations de publication
Date de publication:
15 04 2021
15 04 2021
Historique:
revised:
21
11
2020
received:
13
04
2020
accepted:
08
12
2020
pubmed:
3
2
2021
medline:
25
2
2023
entrez:
2
2
2021
Statut:
ppublish
Résumé
Mitochondrial translation dysfunction is associated with neurodegenerative and cardiovascular diseases. Cells eliminate defective mitochondria by the lysosomal machinery via autophagy. The relationship between mitochondrial translation and lysosomal function is unknown. In this study, mitochondrial translation-deficient hearts from p32-knockout mice were found to exhibit enlarged lysosomes containing lipofuscin, suggesting impaired lysosome and autolysosome function. These mice also displayed autophagic abnormalities, such as p62 accumulation and LC3 localization around broken mitochondria. The expression of genes encoding for nicotinamide adenine dinucleotide (NAD
Identifiants
pubmed: 33528041
doi: 10.15252/embj.2020105268
pmc: PMC8047443
doi:
Substances chimiques
C1qbp protein, mouse
0
Hif1a protein, mouse
0
Hypoxia-Inducible Factor 1, alpha Subunit
0
Map1lc3b protein, mouse
0
Microtubule-Associated Proteins
0
Mitochondrial Proteins
0
NAD
0U46U6E8UK
Glyceraldehyde-3-Phosphate Dehydrogenase (Phosphorylating)
EC 1.2.1.12
Pgk1 protein, mouse
EC 2.7.2.3
Phosphoglycerate Kinase
EC 2.7.2.3
Nicotinamide-Nucleotide Adenylyltransferase
EC 2.7.7.1
nicotinamide mononucleotide adenylyltransferase 3, mouse
EC 2.7.7.1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e105268Informations de copyright
© 2021 The Authors. Published under the terms of the CC BY 4.0 license.
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