Deoxyribonuclease I Inhibitory Properties, Molecular Docking and Molecular Dynamics Simulations of 1-(Pyrrolidin-2-yl)propan-2-one Derivatives.
Deoxyribonuclease I
/ antagonists & inhibitors
Dose-Response Relationship, Drug
Enzyme Inhibitors
/ chemical synthesis
Humans
Molecular Docking Simulation
Molecular Dynamics Simulation
Molecular Structure
Propane
/ analogs & derivatives
Pyrrolidines
/ chemical synthesis
Stereoisomerism
Structure-Activity Relationship
DNase I inhibitors
enzyme inhibition
molecular docking
molecular dynamics
Journal
Chemistry & biodiversity
ISSN: 1612-1880
Titre abrégé: Chem Biodivers
Pays: Switzerland
ID NLM: 101197449
Informations de publication
Date de publication:
Mar 2021
Mar 2021
Historique:
received:
05
12
2020
accepted:
02
02
2021
pubmed:
3
2
2021
medline:
9
7
2021
entrez:
2
2
2021
Statut:
ppublish
Résumé
Deoxyribonuclease I (DNase I) inhibitory properties of two 1-(pyrrolidin-2-yl)propan-2-one derivatives were examined in vitro. Determined IC
Identifiants
pubmed: 33529484
doi: 10.1002/cbdv.202000996
doi:
Substances chimiques
Enzyme Inhibitors
0
Pyrrolidines
0
DNASE1 protein, human
EC 3.1.21.1
Deoxyribonuclease I
EC 3.1.21.1
pyrrolidine
LJU5627FYV
Propane
T75W9911L6
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2000996Subventions
Organisme : Ministry of Education, Science and Technological Development of the Republic of Serbia
ID : 451-03-68/2020-14/200113
Organisme : Ministry of Education, Science and Technological Development of the Republic of Serbia
ID : 451-03-68/2020-14/200026
Organisme : Faculty of Medicine of the University of Niš
ID : 40
Organisme : D. E. Shaw Research
Informations de copyright
© 2021 Wiley-VHCA AG, Zurich, Switzerland.
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