Chain elongators, friends, and foes.
Journal
Current opinion in biotechnology
ISSN: 1879-0429
Titre abrégé: Curr Opin Biotechnol
Pays: England
ID NLM: 9100492
Informations de publication
Date de publication:
02 2021
02 2021
Historique:
received:
19
09
2020
revised:
02
01
2021
accepted:
07
01
2021
pubmed:
3
2
2021
medline:
27
4
2021
entrez:
2
2
2021
Statut:
ppublish
Résumé
Bioproduction of medium chain carboxylic acids has recently emerged as an alternative strategy to valorize low-value organic waste and side-streams. Key to this route is chain elongation, an anaerobic microbial process driven by ethanol, lactic acid, or carbohydrates. Because these technologies use wastes as feedstocks, mixed microbial communities are often considered as biocatalysts. Understanding and steering these microbiomes is key to optimize bioprocess performance. From a meta-analysis of publicly available sequencing data, we (i) explore how the current collection of isolated chain elongators compares to microbiome members, (ii) discuss the main beneficial and antagonistic interactions with community partners, and (iii) identify the key research gaps and needs to help understand chain elongation microbiomes, and design/steer these novel bioproduction processes.
Identifiants
pubmed: 33529974
pii: S0958-1669(21)00010-0
doi: 10.1016/j.copbio.2021.01.005
pii:
doi:
Substances chimiques
Carbohydrates
0
Lactic Acid
33X04XA5AT
Types de publication
Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
99-110Informations de copyright
Copyright © 2021 Elsevier Ltd. All rights reserved.