Chemical Synthesis and NMR Solution Structure of Conotoxin GXIA from

Amino Acid Sequence Animals Conotoxins / analysis Conus Snail Magnetic Resonance Spectroscopy / methods Neurotoxins / analysis Protein Structure, Secondary Protein Structure, Tertiary omega-Conotoxin GVIA / analysis
Conus geographus cone snail conotoxin disulfide-rich inhibitor cystine knot venom

Journal

Marine drugs
ISSN: 1660-3397
Titre abrégé: Mar Drugs
Pays: Switzerland
ID NLM: 101213729

Informations de publication

Date de publication:
26 Jan 2021
Historique:
received: 30 11 2020
revised: 07 01 2021
accepted: 19 01 2021
entrez: 3 2 2021
pubmed: 4 2 2021
medline: 20 5 2021
Statut: epublish

Résumé

Conotoxins are disulfide-rich peptides found in the venom of cone snails. Due to their exquisite potency and high selectivity for a wide range of voltage and ligand gated ion channels they are attractive drug leads in neuropharmacology. Recently, cone snails were found to have the capability to rapidly switch between venom types with different proteome profiles in response to predatory or defensive stimuli. A novel conotoxin, GXIA (original name G117), belonging to the I

Identifiants

DOI: 10.3390/md19020060 PMID: 33530397 PMC: PMC7912261
pubmed: 33530397
pii: md19020060
doi: 10.3390/md19020060
pmc: PMC7912261
pii:
doi:

Substances chimiques

Conotoxins 0
Neurotoxins 0
omega-Conotoxin GVIA 92078-76-7

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Australian Research Council
ID : FT130100890
Organisme : National Health and Medical Research Council
ID : APP1072113

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Auteurs

David A Armstrong (DA)

School of Biomedical Sciences, Faculty of Medicine, The University of Queensland, Brisbane, QLD 4072, Australia.

Ai-Hua Jin (AH)

Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia.

Nayara Braga Emidio (N)

Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia.
ORCID: 0000-0001-7835-9636

Richard J Lewis (RJ)

Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia.
ORCID: 0000-0003-3470-923X

Paul F Alewood (PF)

Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia.

K Johan Rosengren (KJ)

School of Biomedical Sciences, Faculty of Medicine, The University of Queensland, Brisbane, QLD 4072, Australia.
ORCID: 0000-0002-5007-8434

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Classifications MeSH

questionsmedicales.fr › Sciences de l'information › Sources d'information › Services d'information › Documentation › Données de séquences moléculaires › Séquence d'acides aminés › Chemical Synthesis and NMR Solution Structure...
questionsmedicales.fr › Eucaryotes › Animaux › Chemical Synthesis and NMR Solution Structure...
questionsmedicales.fr › Facteurs biologiques › Toxines biologiques › Venins › Venins de mollusque › Conotoxines › Chemical Synthesis and NMR Solution Structure...
questionsmedicales.fr › Eucaryotes › Animaux › Invertébrés › Mollusca › Gastropoda › Conus › Chemical Synthesis and NMR Solution Structure...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Analyse spectrale › Spectroscopie par résonance magnétique › Chemical Synthesis and NMR Solution Structure...
questionsmedicales.fr › Actions chimiques et utilisations › Actions toxiques › Noxas › Neurotoxines › Chemical Synthesis and NMR Solution Structure...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Conformation moléculaire › Conformation des protéines › Structure secondaire des protéines › Chemical Synthesis and NMR Solution Structure...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Conformation moléculaire › Conformation des protéines › Structure tertiaire des protéines › Chemical Synthesis and NMR Solution Structure...
questionsmedicales.fr › Facteurs biologiques › Toxines biologiques › Venins › Venins de mollusque › Conotoxines › Conotoxines-oméga › Conotoxine-oméga-GVIA › Chemical Synthesis and NMR Solution Structure...