Investigating the possible association between NLRP3 gene polymorphisms and myasthenia gravis.
NLRP3
inflammasome
myasthenia gravis
single-nucleotide polymorphisms
Journal
Muscle & nerve
ISSN: 1097-4598
Titre abrégé: Muscle Nerve
Pays: United States
ID NLM: 7803146
Informations de publication
Date de publication:
05 2021
05 2021
Historique:
revised:
26
01
2021
received:
08
08
2019
accepted:
31
01
2021
pubmed:
4
2
2021
medline:
11
6
2021
entrez:
3
2
2021
Statut:
ppublish
Résumé
In this case-control study, we investigated the association between nucleotide oligomerization domain-like receptor family pyrin domain containing 3 (NLRP3) single-nucleotide polymorphisms (SNPs) rs10754558, rs3806265, rs4612666, and rs35829419 and myasthenia gravis (MG). Samples from MG patients were selected from a previous study conducted in our neuromuscular clinic, which investigated the association between human leukocyte antigen (HLA) class II genes and MG. Genetic data of controls were also available from another study. The NLRP3 SNPs genotyping was performed using the TaqMan method. A total of 93 blood samples from eligible Iranian patients with MG and 56 samples from healthy controls were obtained. The NLRP3 rs3806265 "C" allele was significantly more frequent in MG patients (P < .001; odd ratio [OR] = 2.33, 95% confidence interval [CI]: 1.4-4.0) than controls. The "CC" genotype of this SNP was found in 18.27% of patients, but none of the controls (P < .001). The distribution of other SNPs was similar between the groups. These preliminary results suggest that there might be some associations between the NLRP3 gene polymorphism and MG.
Substances chimiques
NLR Family, Pyrin Domain-Containing 3 Protein
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
730-736Informations de copyright
© 2021 Wiley Periodicals LLC.
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