Two cases of refractory eosinophilic granulomatosis with polyangiitis wherein mepolizumab was effective against pulmonary and ear lesions.

Antibodies, Monoclonal, Humanized / therapeutic use Churg-Strauss Syndrome / diagnosis Ear Diseases / drug therapy Granulomatosis with Polyangiitis / diagnosis Humans Lung Diseases / drug therapy Treatment Outcome
ANCA-associated vasculitis Eosinophilic granulomatosis with polyangiitis lung lesions mepolizumab otitis media with ANCA-associated vasculitis

Journal

Modern rheumatology case reports
ISSN: 2472-5625
Titre abrégé: Mod Rheumatol Case Rep
Pays: England
ID NLM: 101761026

Informations de publication

Date de publication:
07 2021
Historique:
pubmed: 4 2 2021
medline: 1 12 2021
entrez: 3 2 2021
Statut: ppublish

Résumé

Recently, mepolizumab, an interleukin (IL)-5 inhibitor, has been indicated for the treatment of eosinophilic granulomatosis with polyangiitis (EGPA) refractory to standard therapies. However, no reports have compared the efficacy of mepolizumab according to symptoms and organ lesions. Herein, we report two cases in which mepolizumab was highly effective in the management of EGPA with lung lesions and otitis media refractory to treatment with multiple immunosuppressive agents. These two cases suggest that mepolizumab is effective in treating pulmonary and ear lesions in EGPA.

Identifiants

DOI: 10.1080/24725625.2021.1881205 PMID: 33533698
pubmed: 33533698
doi: 10.1080/24725625.2021.1881205
doi:

Substances chimiques

Antibodies, Monoclonal, Humanized 0
mepolizumab 90Z2UF0E52

Types de publication

Case Reports

Langues

eng

Sous-ensembles de citation

IM

Pagination

327-332

Auteurs

Yusuke Ushio (Y)

Department of Internal Medicine, Division of Haematology, Rheumatology and Respiratory Medicine, Faculty of Medicine, Kagawa University, Kagawa, Japan.
ORCID: 0000-0002-6240-3820

Risa Wakiya (R)

Department of Internal Medicine, Division of Haematology, Rheumatology and Respiratory Medicine, Faculty of Medicine, Kagawa University, Kagawa, Japan.

Mikiya Kato (M)

Department of Internal Medicine, Division of Haematology, Rheumatology and Respiratory Medicine, Faculty of Medicine, Kagawa University, Kagawa, Japan.

Tomohiro Kameda (T)

Department of Internal Medicine, Division of Haematology, Rheumatology and Respiratory Medicine, Faculty of Medicine, Kagawa University, Kagawa, Japan.

Shusaku Nakashima (S)

Department of Internal Medicine, Division of Haematology, Rheumatology and Respiratory Medicine, Faculty of Medicine, Kagawa University, Kagawa, Japan.

Hiromi Shimada (H)

Department of Internal Medicine, Division of Haematology, Rheumatology and Respiratory Medicine, Faculty of Medicine, Kagawa University, Kagawa, Japan.

Mai Mahmoud Fahmy Mansour (MMF)

Department of Internal Medicine, Division of Haematology, Rheumatology and Respiratory Medicine, Faculty of Medicine, Kagawa University, Kagawa, Japan.

Koichi Sugihara (K)

Department of Internal Medicine, Division of Haematology, Rheumatology and Respiratory Medicine, Faculty of Medicine, Kagawa University, Kagawa, Japan.

Takenori Miyashita (T)

Department of Otorhinolaryngology, Faculty of Medicine, Kagawa University, Kagawa, Japan.

Norimitsu Kadowaki (N)

Department of Internal Medicine, Division of Haematology, Rheumatology and Respiratory Medicine, Faculty of Medicine, Kagawa University, Kagawa, Japan.

Hiroaki Dobashi (H)

Department of Internal Medicine, Division of Haematology, Rheumatology and Respiratory Medicine, Faculty of Medicine, Kagawa University, Kagawa, Japan.

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Anticorps › Anticorps monoclonaux › Anticorps monoclonaux humanisés › Two cases of refractory eosinophilic...
questionsmedicales.fr › Maladies du système immunitaire › Maladies auto-immunes › Vascularites associées aux anticorps anti-cytoplasme des neutrophiles › Syndrome de Churg-Strauss › Two cases of refractory eosinophilic...
questionsmedicales.fr › Maladies oto-rhino-laryngologiques › Maladies des oreilles › Two cases of refractory eosinophilic...
questionsmedicales.fr › Maladies du système immunitaire › Maladies auto-immunes › Vascularites associées aux anticorps anti-cytoplasme des neutrophiles › Granulomatose avec polyangéite › Two cases of refractory eosinophilic...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Two cases of refractory eosinophilic...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Maladies pulmonaires › Two cases of refractory eosinophilic...
questionsmedicales.fr › Qualité, accès, évaluation des soins de santé › Qualité des soins de santé › Mécanismes d'évaluation des soins de santé › Évaluation des résultats et des processus en soins de santé › Évaluation de résultat (soins) › Résultat thérapeutique › Two cases of refractory eosinophilic...