Biophysics of Notch Signaling.
Notch signaling
intramembrane proteolysis
mechanotransduction
signal transduction
structural biology
transcription
Journal
Annual review of biophysics
ISSN: 1936-1238
Titre abrégé: Annu Rev Biophys
Pays: United States
ID NLM: 101469708
Informations de publication
Date de publication:
06 05 2021
06 05 2021
Historique:
pubmed:
4
2
2021
medline:
21
5
2021
entrez:
3
2
2021
Statut:
ppublish
Résumé
Notch signaling is a conserved system of communication between adjacent cells, influencing numerous cell fate decisions in the development of multicellular organisms. Aberrant signaling is also implicated in many human pathologies. At its core, Notch has a mechanotransduction module that decodes receptor-ligand engagement at the cell surface under force to permit proteolytic cleavage of the receptor, leading to the release of the Notch intracellular domain (NICD). NICD enters the nucleus and acts as a transcriptional effector to regulate expression of Notch-responsive genes. In this article, we review and integrate current understanding of the detailed molecular basis for Notch signal transduction, highlighting quantitative, structural, and dynamic features of this developmentally central signaling mechanism. We discuss the implications of this mechanistic understanding for the functionality of the signaling pathway in different molecular and cellular contexts.
Identifiants
pubmed: 33534608
doi: 10.1146/annurev-biophys-101920-082204
pmc: PMC8105286
mid: NIHMS1690127
doi:
Substances chimiques
Receptors, Notch
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
157-189Subventions
Organisme : NCI NIH HHS
ID : R35 CA220340
Pays : United States
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