David Sprinzak

Affiliations

George S. Wise Faculty of Life Sciences, School of Neurobiology, Biochemistry, and Biophysics, Tel Aviv University, Tel Aviv 69978, Israel.

Publications (25)

Structural requirements for activity of Mind bomb1 in Notch signaling.

Structure (London, England : 1993)

Avec: Ruili Cao , Oren Gozlan , Alina Airich , Lena Tveriakhina , Haixia Zhou , Hanjie Jiang , Philip A Cole , Jon C Aster , Thomas Klein , David Sprinzak , Stephen C Blacklow

Precise alternating cellular pattern in the inner ear by coordinated hopping intercalations and delaminations.

Science advances

Avec: Roie Cohen , Shahar Taiber , Olga Loza , Shahar Kasirer , Shiran Woland , David Sprinzak

Enhancer architecture sensitizes cell specific responses to

eLife

Avec: Yi Kuang , Ohad Golan , Kristina Preusse , Brittany Cain , Collin J Christensen , Joseph Salomone , Ian Campbell , FearGod V Okwubido-Williams , Matthew R Hass , Zhenyu Yuan , Nathanel Eafergan , Kenneth H Moberg , Rhett A Kovall , Raphael Kopan , David Sprinzak , Brian Gebelein

Structure of the planar cell polarity cadherins Fat4 and Dachsous1.

Nature communications

Avec: Elliot Medina , Yathreb Easa , Daniel K Lester , Eric K Lau , David Sprinzak , Vincent C Luca

Notch signaling in development and homeostasis.

Development (Cambridge, England)

Avec: Oren Gozlan , David Sprinzak

Notch ligand Dll4 impairs cell recruitment to aortic clusters and limits blood stem cell generation.

The EMBO journal

Avec: Cristina Porcheri , Ohad Golan , Fernando J Calero-Nieto , Roshana Thambyrajah , Cristina Ruiz-Herguido , Xiaonan Wang , Francesca Catto , Yolanda Guillén , Roshani Sinha , Jessica González , Sarah J Kinston , Samanta A Mariani , Antonio Maglitto , Chris S Vink , Elaine Dzierzak , Pierre Charbord , Bertie Göttgens , Lluis Espinosa , David Sprinzak , Anna Bigas

Roadmap for the multiscale coupling of biochemical and mechanical signals during development.

Physical biology

Avec: Pierre-François Lenne , Edwin Munro , Idse Heemskerk , Aryeh Warmflash , Laura Bocanegra-Moreno , Kasumi Kishi , Anna Kicheva , Yuchen Long , Antoine Fruleux , Arezki Boudaoud , Timothy E Saunders , Paolo Caldarelli , Arthur Michaut , Jerome Gros , Yonit Maroudas-Sacks , Kinneret Keren , Edouard Hannezo , Zev J Gartner , Benjamin Stormo , Amy Gladfelter , Alan Rodrigues , Amy Shyer , Nicolas Minc , Jean-Léon Maître , Stefano Di Talia , Bassma Khamaisi , David Sprinzak , Sham Tlili

Mechanical forces shaping the development of the inner ear.

Biophysical journal

Avec: Roie Cohen , David Sprinzak

Matrix stiffness regulates Notch signaling activity in endothelial cells.

Journal of cell science

Avec: Maibritt Kretschmer , Rose Mamistvalov , David Sprinzak , Angelika M Vollmar , Stefan Zahler

Novel Association of the NOTCH Pathway Regulator MIB1 Gene With the Development of Bicuspid Aortic Valve.

JAMA cardiology

Avec: Idit Tessler , Juliette Albuisson , Rebeca Piñeiro-Sabarís , Aline Verstraeten , Hatem Elif Kamber Kaya , Marcos Siguero-Álvarez , Guillaume Goudot , Donal MacGrogan , Ilse Luyckx , Shoshana Shpitzen , Galina Levin , Guy Kelman , Noga Reshef , Hugo Mananet , Jake Holdcraft , Jochen D Muehlschlegel , Gina M Peloso , Olya Oppenheim , Charles Cheng , Jean-Michael Mazzella , Gregor Andelfinger , Seema Mital , Per Eriksson , Clarisse Billon , Mahyar Heydarpour , Harry C Dietz , Xavier Jeunemaitre , Eran Leitersdorf , David Sprinzak , Stephen C Blacklow , Simon C Body , Shai Carmi , Bart Loeys , José Luis de la Pompa , Dan Gilon , Emmanuel Messas , Ronen Durst

Cis-inhibition suppresses basal Notch signaling during sensory organ precursor selection.

Proceedings of the National Academy of Sciences of the United States of America

Avec: Tobias Troost , Udi Binshtok , David Sprinzak , Thomas Klein

Modelling cell surface dynamics and cell-cell interactions using Cell Studio: a three-dimensional visualization tool based on gaming technology.

Journal of the Royal Society, Interface

Avec: Asaf Liberman , Matan Mussel , Danny Kario , David Sprinzak , Uri Nevo

Notch-Mediated Tumor-Stroma-Inflammation Networks Promote Invasive Properties and CXCL8 Expression in Triple-Negative Breast Cancer.

Frontiers in immunology

Avec: Yulia Liubomirski , Shalom Lerrer , Tsipi Meshel , Dina Morein , Linor Rubinstein-Achiasaf , David Sprinzak , Stefan Wiemann , Cindy Körner , Marcelo Ehrlich , Adit Ben-Baruch

Enhancers with cooperative Notch binding sites are more resistant to regulation by the Hairless co-repressor.

PLoS genetics

Avec: Yi Kuang , Anna Pyo , Natanel Eafergan , Brittany Cain , Lisa M Gutzwiller , Ofri Axelrod , Ellen K Gagliani , Matthew T Weirauch , Raphael Kopan , Rhett A Kovall , David Sprinzak , Brian Gebelein

Functional Comparison between Endogenous and Synthetic Notch Systems.

ACS synthetic biology

Avec: Bassma Khamaisi , Vincent C Luca , Stephen C Blacklow , David Sprinzak

Endothelial Notch1 signaling in white adipose tissue promotes cancer cachexia.

Nature cancer

Avec: Jacqueline Taylor , Leonie Uhl , Iris Moll , Sana Safatul Hasan , Lena Wiedmann , Jakob Morgenstern , Benedetto Daniele Giaimo , Tobias Friedrich , Elisenda Alsina-Sanchis , Francesca De Angelis Rigotti , Ronja Mülfarth , Sarah Kaltenbach , Darius Schenk , Felix Nickel , Thomas Fleming , David Sprinzak , Carolin Mogler , Thomas Korff , Adrian T Billeter , Beat P Müller-Stich , Mauricio Berriel Diaz , Tilman Borggrefe , Stephan Herzig , Maria Rohm , Juan Rodriguez-Vita , Andreas Fischer

Therapeutic gene silencing of

Science advances

Avec: Sushmita Chatterjee , Gonna Somu Naidu , Inbal Hazan-Halevy , Hanna Grobe , Assaf Ezra , Preeti Sharma , Meir Goldsmith , Srinivas Ramishetti , David Sprinzak , Ronen Zaidel-Bar , Dan Peer

Genetic and Mechanical Regulation of Intestinal Smooth Muscle Development.

Cell

Avec: Tyler R Huycke , Bess M Miller , Hasreet K Gill , Nandan L Nerurkar , David Sprinzak , L Mahadevan , Clifford J Tabin

Dynamic spatiotemporal coordination of neural stem cell fate decisions occurs through local feedback in the adult vertebrate brain.

Cell stem cell

Avec: Nicolas Dray , Laure Mancini , Udi Binshtok , Felix Cheysson , Willy Supatto , Pierre Mahou , Sébastien Bedu , Sara Ortica , Emmanuel Than-Trong , Monika Krecsmarik , Sébastien Herbert , Jean-Baptiste Masson , Jean-Yves Tinevez , Gabriel Lang , Emmanuel Beaurepaire , David Sprinzak , Laure Bally-Cuif

Mechanical forces drive ordered patterning of hair cells in the mammalian inner ear.

Nature communications

Avec: Roie Cohen , Liat Amir-Zilberstein , Micha Hersch , Shiran Woland , Olga Loza , Shahar Taiber , Fumio Matsuzaki , Sven Bergmann , Karen B Avraham , David Sprinzak

Neonatal AAV gene therapy rescues hearing in a mouse model of SYNE4 deafness.

EMBO molecular medicine

Avec: Shahar Taiber , Roie Cohen , Ofer Yizhar-Barnea , David Sprinzak , Jeffrey R Holt , Karen B Avraham

Biophysics of Notch Signaling.

Annual review of biophysics

Avec: David Sprinzak , Stephen C Blacklow

Notch dimerization and gene dosage are important for normal heart development, intestinal stem cell maintenance, and splenic marginal zone B-cell homeostasis during mite infestation.

PLoS biology

Avec: Francis M Kobia , Kristina Preusse , Quanhui Dai , Nicholas Weaver , Matthew R Hass , Praneet Chaturvedi , Sarah J Stein , Warren S Pear , Zhenyu Yuan , Rhett A Kovall , Yi Kuang , Natanel Eafergen , David Sprinzak , Brian Gebelein , Eric W Brunskill , Raphael Kopan

Structural Requirements for Activity of Mind bomb1 in Notch Signaling.

bioRxiv : the preprint server for biology

Avec: Ruili Cao , Oren Gozlan , Lena Tveriakhina , Haixia Zhou , Hanjie Jiang , Philip A Cole , Jon C Aster , David Sprinzak , Stephen C Blacklow

A Nesprin-4/kinesin-1 cargo model for nuclear positioning in cochlear outer hair cells.

Frontiers in cell and developmental biology

Avec: Shahar Taiber , Oren Gozlan , Roie Cohen , Leonardo R Andrade , Ellen F Gregory , Daniel A Starr , Yehu Moran , Rebecca Hipp , Matthew W Kelley , Uri Manor , David Sprinzak , Karen B Avraham

Réseau de co-auteurs

Stephen C Blacklow 5 collaborations

Roie Cohen 5 collaborations

Oren Gozlan 4 collaborations

Shahar Taiber 4 collaborations

Yi Kuang 3 collaborations

Rhett A Kovall 3 collaborations

Raphael Kopan 3 collaborations

Brian Gebelein 3 collaborations

Karen B Avraham 3 collaborations

Ruili Cao 2 collaborations

Lena Tveriakhina 2 collaborations

Haixia Zhou 2 collaborations

Hanjie Jiang 2 collaborations

Philip A Cole 2 collaborations

Jon C Aster 2 collaborations

Thomas Klein 2 collaborations

Olga Loza 2 collaborations

Shiran Woland 2 collaborations

Ohad Golan 2 collaborations

Kristina Preusse 2 collaborations

Brittany Cain 2 collaborations

Matthew R Hass 2 collaborations

Zhenyu Yuan 2 collaborations

Vincent C Luca 2 collaborations

Bassma Khamaisi 2 collaborations

Udi Binshtok 2 collaborations

Alina Airich 1 collaboration

Shahar Kasirer 1 collaboration

Collin J Christensen 1 collaboration

Joseph Salomone 1 collaboration

Ian Campbell 1 collaboration

FearGod V Okwubido-Williams 1 collaboration

Nathanel Eafergan 1 collaboration

Kenneth H Moberg 1 collaboration

Elliot Medina 1 collaboration

Yathreb Easa 1 collaboration

Daniel K Lester 1 collaboration

Eric K Lau 1 collaboration

Cristina Porcheri 1 collaboration

Fernando J Calero-Nieto 1 collaboration

Roshana Thambyrajah 1 collaboration

Cristina Ruiz-Herguido 1 collaboration

Xiaonan Wang 1 collaboration

Francesca Catto 1 collaboration

Yolanda Guillén 1 collaboration

Roshani Sinha 1 collaboration

Jessica González 1 collaboration

Sarah J Kinston 1 collaboration

Samanta A Mariani 1 collaboration

Antonio Maglitto 1 collaboration

Chris S Vink 1 collaboration

Elaine Dzierzak 1 collaboration

Pierre Charbord 1 collaboration

Bertie Göttgens 1 collaboration

Lluis Espinosa 1 collaboration

Anna Bigas 1 collaboration

Pierre-François Lenne 1 collaboration

Edwin Munro 1 collaboration

Idse Heemskerk 1 collaboration

Aryeh Warmflash 1 collaboration

Laura Bocanegra-Moreno 1 collaboration

Kasumi Kishi 1 collaboration

Anna Kicheva 1 collaboration

Yuchen Long 1 collaboration

Antoine Fruleux 1 collaboration

Arezki Boudaoud 1 collaboration

Timothy E Saunders 1 collaboration

Paolo Caldarelli 1 collaboration

Arthur Michaut 1 collaboration

Jerome Gros 1 collaboration

Yonit Maroudas-Sacks 1 collaboration

Kinneret Keren 1 collaboration

Edouard Hannezo 1 collaboration

Zev J Gartner 1 collaboration

Benjamin Stormo 1 collaboration

Amy Gladfelter 1 collaboration

Alan Rodrigues 1 collaboration

Amy Shyer 1 collaboration

Nicolas Minc 1 collaboration

Jean-Léon Maître 1 collaboration

Stefano Di Talia 1 collaboration

Sham Tlili 1 collaboration

Maibritt Kretschmer 1 collaboration

Rose Mamistvalov 1 collaboration

Angelika M Vollmar 1 collaboration

Stefan Zahler 1 collaboration

Idit Tessler 1 collaboration

Juliette Albuisson 1 collaboration

Rebeca Piñeiro-Sabarís 1 collaboration

Aline Verstraeten 1 collaboration

Hatem Elif Kamber Kaya 1 collaboration

Marcos Siguero-Álvarez 1 collaboration

Guillaume Goudot 1 collaboration

Donal MacGrogan 1 collaboration

Ilse Luyckx 1 collaboration

Shoshana Shpitzen 1 collaboration

Galina Levin 1 collaboration

Guy Kelman 1 collaboration

Noga Reshef 1 collaboration

Hugo Mananet 1 collaboration

Jake Holdcraft 1 collaboration

Jochen D Muehlschlegel 1 collaboration

Gina M Peloso 1 collaboration

Olya Oppenheim 1 collaboration

Charles Cheng 1 collaboration

Jean-Michael Mazzella 1 collaboration

Gregor Andelfinger 1 collaboration

Seema Mital 1 collaboration

Per Eriksson 1 collaboration

Clarisse Billon 1 collaboration

Mahyar Heydarpour 1 collaboration

Harry C Dietz 1 collaboration

Xavier Jeunemaitre 1 collaboration

Eran Leitersdorf 1 collaboration

Simon C Body 1 collaboration

Shai Carmi 1 collaboration

Bart Loeys 1 collaboration

José Luis de la Pompa 1 collaboration

Dan Gilon 1 collaboration

Emmanuel Messas 1 collaboration

Ronen Durst 1 collaboration

Tobias Troost 1 collaboration

Asaf Liberman 1 collaboration

Matan Mussel 1 collaboration

Danny Kario 1 collaboration

Uri Nevo 1 collaboration

Yulia Liubomirski 1 collaboration

Shalom Lerrer 1 collaboration

Tsipi Meshel 1 collaboration

Dina Morein 1 collaboration

Linor Rubinstein-Achiasaf 1 collaboration

Stefan Wiemann 1 collaboration

Cindy Körner 1 collaboration

Marcelo Ehrlich 1 collaboration

Adit Ben-Baruch 1 collaboration

Anna Pyo 1 collaboration

Natanel Eafergan 1 collaboration

Lisa M Gutzwiller 1 collaboration

Ofri Axelrod 1 collaboration

Ellen K Gagliani 1 collaboration

Matthew T Weirauch 1 collaboration

Jacqueline Taylor 1 collaboration

Leonie Uhl 1 collaboration

Iris Moll 1 collaboration

Sana Safatul Hasan 1 collaboration

Lena Wiedmann 1 collaboration

Jakob Morgenstern 1 collaboration

Benedetto Daniele Giaimo 1 collaboration

Tobias Friedrich 1 collaboration

Elisenda Alsina-Sanchis 1 collaboration

Francesca De Angelis Rigotti 1 collaboration

Ronja Mülfarth 1 collaboration

Sarah Kaltenbach 1 collaboration

Darius Schenk 1 collaboration

Felix Nickel 1 collaboration

Thomas Fleming 1 collaboration

Carolin Mogler 1 collaboration

Thomas Korff 1 collaboration

Adrian T Billeter 1 collaboration

Beat P Müller-Stich 1 collaboration

Mauricio Berriel Diaz 1 collaboration

Tilman Borggrefe 1 collaboration

Stephan Herzig 1 collaboration

Maria Rohm 1 collaboration

Juan Rodriguez-Vita 1 collaboration

Andreas Fischer 1 collaboration

Sushmita Chatterjee 1 collaboration

Gonna Somu Naidu 1 collaboration

Inbal Hazan-Halevy 1 collaboration

Hanna Grobe 1 collaboration

Assaf Ezra 1 collaboration

Preeti Sharma 1 collaboration

Meir Goldsmith 1 collaboration

Srinivas Ramishetti 1 collaboration

Ronen Zaidel-Bar 1 collaboration

Dan Peer 1 collaboration

Tyler R Huycke 1 collaboration

Bess M Miller 1 collaboration

Hasreet K Gill 1 collaboration

Nandan L Nerurkar 1 collaboration

L Mahadevan 1 collaboration

Clifford J Tabin 1 collaboration

Nicolas Dray 1 collaboration

Laure Mancini 1 collaboration

Felix Cheysson 1 collaboration

Willy Supatto 1 collaboration

Pierre Mahou 1 collaboration

Sébastien Bedu 1 collaboration

Sara Ortica 1 collaboration

Emmanuel Than-Trong 1 collaboration

Monika Krecsmarik 1 collaboration

Sébastien Herbert 1 collaboration

Jean-Baptiste Masson 1 collaboration

Jean-Yves Tinevez 1 collaboration

Gabriel Lang 1 collaboration

Emmanuel Beaurepaire 1 collaboration

Laure Bally-Cuif 1 collaboration

Liat Amir-Zilberstein 1 collaboration

Micha Hersch 1 collaboration

Fumio Matsuzaki 1 collaboration

Sven Bergmann 1 collaboration

Ofer Yizhar-Barnea 1 collaboration

Jeffrey R Holt 1 collaboration

Francis M Kobia 1 collaboration

Quanhui Dai 1 collaboration

Nicholas Weaver 1 collaboration

Praneet Chaturvedi 1 collaboration

Sarah J Stein 1 collaboration

Warren S Pear 1 collaboration

Natanel Eafergen 1 collaboration

Eric W Brunskill 1 collaboration

Leonardo R Andrade 1 collaboration

Ellen F Gregory 1 collaboration

Daniel A Starr 1 collaboration

Yehu Moran 1 collaboration

Rebecca Hipp 1 collaboration

Matthew W Kelley 1 collaboration

Uri Manor 1 collaboration