Roadmap for the multiscale coupling of biochemical and mechanical signals during development.
embryogenesis
morphogenesis
signalling
Journal
Physical biology
ISSN: 1478-3975
Titre abrégé: Phys Biol
Pays: England
ID NLM: 101197454
Informations de publication
Date de publication:
14 04 2021
14 04 2021
Historique:
received:
29
10
2020
accepted:
04
12
2020
pubmed:
5
12
2020
medline:
3
11
2021
entrez:
4
12
2020
Statut:
epublish
Résumé
The way in which interactions between mechanics and biochemistry lead to the emergence of complex cell and tissue organization is an old question that has recently attracted renewed interest from biologists, physicists, mathematicians and computer scientists. Rapid advances in optical physics, microscopy and computational image analysis have greatly enhanced our ability to observe and quantify spatiotemporal patterns of signalling, force generation, deformation, and flow in living cells and tissues. Powerful new tools for genetic, biophysical and optogenetic manipulation are allowing us to perturb the underlying machinery that generates these patterns in increasingly sophisticated ways. Rapid advances in theory and computing have made it possible to construct predictive models that describe how cell and tissue organization and dynamics emerge from the local coupling of biochemistry and mechanics. Together, these advances have opened up a wealth of new opportunities to explore how mechanochemical patterning shapes organismal development. In this roadmap, we present a series of forward-looking case studies on mechanochemical patterning in development, written by scientists working at the interface between the physical and biological sciences, and covering a wide range of spatial and temporal scales, organisms, and modes of development. Together, these contributions highlight the many ways in which the dynamic coupling of mechanics and biochemistry shapes biological dynamics: from mechanoenzymes that sense force to tune their activity and motor output, to collectives of cells in tissues that flow and redistribute biochemical signals during development.
Identifiants
pubmed: 33276350
doi: 10.1088/1478-3975/abd0db
pmc: PMC8380410
mid: NIHMS1729815
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIGMS NIH HHS
ID : R35 GM138346
Pays : United States
Organisme : NCI NIH HHS
ID : U01 CA244109
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK126376
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM135462
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM122936
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM126122
Pays : United States
Organisme : NICHD NIH HHS
ID : DP2 HD080351
Pays : United States
Informations de copyright
Creative Commons Attribution license.
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