Influenza and pneumococcus vaccination rates in pediatric dialysis patients in Europe: recommendations vs reality A European Pediatric Dialysis Working Group and European Society for Pediatric Nephrology Dialysis Working Group study
Adolescent
Antibodies
/ analysis
Child
Child, Preschool
Humans
Immunization
/ statistics & numerical data
Infant
Influenza Vaccines
/ administration & dosage
Influenza, Human
/ prevention & control
Nephrology
/ standards
Pediatrics
Pneumococcal Vaccines
/ administration & dosage
Renal Dialysis
/ methods
Renal Insufficiency, Chronic
/ complications
Retrospective Studies
Societies, Medical
Streptococcus pneumoniae
Vaccination
/ statistics & numerical data
immunization
Dialysis
influenza vaccine
pneumococcal vaccine
accination
Journal
Turkish journal of medical sciences
ISSN: 1303-6165
Titre abrégé: Turk J Med Sci
Pays: Turkey
ID NLM: 9441758
Informations de publication
Date de publication:
13 12 2021
13 12 2021
Historique:
received:
03
12
2020
accepted:
03
02
2021
entrez:
4
2
2021
pubmed:
5
2
2021
medline:
28
12
2021
Statut:
epublish
Résumé
Children on dialysis are under increased risk of influenza and invasive pneumococcal disease. Although vaccination against these microorganisms are recommended in dialysis patients and despite the fact that these vaccines can reduce disease burden and rates of hospitalization due to infection, vaccination rates are below expected and desired. We aimed to evaluate influenza and pneumococcal vaccination and infection rates in European pediatric dialysis centers. In 16 centers from 11 countries, 357 pediatric dialysis patients were evaluated retrospectively during 1 year
of observation period between 01.01.2014 and 01.01.2015. In all centers, vaccination policy included immunization of dialysis patients with inactive influenza vaccine and pneumococcal conjugate vaccine (PCV). Fifty percent of the centers recommended pneumococcal polysaccharide vaccine following routine PCV series. A significantly higher pneumococcal vaccination rate (43.9%) was seen in peritoneal dialysis (PD) patients compared to those on hemodialysis (HD) (32.9%) (p = 0.035), while the rates for influenza were similar (42.4% and 46.1% respectively, p = 0.496). Among all dialysis patients, 2.2% (n = 8) developed pneumonia and 6.4% (n = 23) was infected by Influenza. Pneumococcic pneumonia rate was 5% for 140 patients who received antipneumococcal vaccine, while only one pneumonia episode was recorded out of 217 unvaccinated patients (p = 0.007). The influenza virus infection rates were similar for patients vaccinated and nonvaccinated (7 % and 6 %, respectively). Although influenza and pneumococcal vaccines are highly recommended in pediatric dialysis patients, vaccination rates
were lower than expected. Pneumococcal vaccination rates were higher in PD compared to the patients on HD. The rate of children
with influenza infection was higher than pneumonia. The efficacy of influenza and pneumococcal vaccines was highlighted by the low infection rates. Higher pneumonia rates in patients vaccinated against pneumococcus compared to unvaccinated ones might be due to coexisting risk factors.
Sections du résumé
Background/aim
Children on dialysis are under increased risk of influenza and invasive pneumococcal disease. Although vaccination against these microorganisms are recommended in dialysis patients and despite the fact that these vaccines can reduce disease burden and rates of hospitalization due to infection, vaccination rates are below expected and desired. We aimed to evaluate influenza and pneumococcal vaccination and infection rates in European pediatric dialysis centers.
Materials and methods
In 16 centers from 11 countries, 357 pediatric dialysis patients were evaluated retrospectively during 1 year
of observation period between 01.01.2014 and 01.01.2015.
Results
In all centers, vaccination policy included immunization of dialysis patients with inactive influenza vaccine and pneumococcal conjugate vaccine (PCV). Fifty percent of the centers recommended pneumococcal polysaccharide vaccine following routine PCV series. A significantly higher pneumococcal vaccination rate (43.9%) was seen in peritoneal dialysis (PD) patients compared to those on hemodialysis (HD) (32.9%) (p = 0.035), while the rates for influenza were similar (42.4% and 46.1% respectively, p = 0.496). Among all dialysis patients, 2.2% (n = 8) developed pneumonia and 6.4% (n = 23) was infected by Influenza. Pneumococcic pneumonia rate was 5% for 140 patients who received antipneumococcal vaccine, while only one pneumonia episode was recorded out of 217 unvaccinated patients (p = 0.007). The influenza virus infection rates were similar for patients vaccinated and nonvaccinated (7 % and 6 %, respectively).
Conclusions
Although influenza and pneumococcal vaccines are highly recommended in pediatric dialysis patients, vaccination rates
were lower than expected. Pneumococcal vaccination rates were higher in PD compared to the patients on HD. The rate of children
with influenza infection was higher than pneumonia. The efficacy of influenza and pneumococcal vaccines was highlighted by the low infection rates. Higher pneumonia rates in patients vaccinated against pneumococcus compared to unvaccinated ones might be due to coexisting risk factors.
Substances chimiques
Antibodies
0
Influenza Vaccines
0
Pneumococcal Vaccines
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2881-2886Informations de copyright
The authors declare that there are no competing conflicts of interest.