Eosinophils attenuate hepatic ischemia-reperfusion injury in mice through ST2-dependent IL-13 production.
Journal
Science translational medicine
ISSN: 1946-6242
Titre abrégé: Sci Transl Med
Pays: United States
ID NLM: 101505086
Informations de publication
Date de publication:
03 02 2021
03 02 2021
Historique:
received:
18
03
2020
revised:
28
09
2020
accepted:
12
01
2021
entrez:
4
2
2021
pubmed:
5
2
2021
medline:
13
7
2021
Statut:
ppublish
Résumé
Eosinophils are a myeloid cell subpopulation that mediates type 2 T helper cell immune responses. Unexpectedly, we identified a rapid accumulation of eosinophils in 22 human liver grafts after hepatic transplantation. In contrast, no eosinophils were detectable in healthy liver tissues before transplantation. Studies with two genetic mouse models of eosinophil deficiency and a mouse model of antibody-mediated eosinophil depletion revealed exacerbated liver injury after hepatic ischemia and reperfusion. Adoptive transfer of bone marrow-derived eosinophils normalized liver injury of eosinophil-deficient mice and reduced hepatic ischemia and reperfusion injury in wild-type mice. Mechanistic studies combining genetic and adoptive transfer approaches identified a critical role of suppression of tumorigenicity (ST2)-dependent production of interleukin-13 by eosinophils in the hepatoprotection against ischemia-reperfusion-induced injury. Together, these data provide insight into a mechanism of eosinophil-mediated liver protection that could serve as a therapeutic target to improve outcomes of patients undergoing liver transplantation.
Identifiants
pubmed: 33536281
pii: 13/579/eabb6576
doi: 10.1126/scitranslmed.abb6576
pmc: PMC8167890
mid: NIHMS1701463
pii:
doi:
Substances chimiques
Interleukin-13
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NHLBI NIH HHS
ID : P01 HL114457
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL109233
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL124165
Pays : United States
Organisme : NIAAA NIH HHS
ID : R21 AA024636
Pays : United States
Organisme : NIEHS NIH HHS
ID : R01 ES019311
Pays : United States
Organisme : NIAID NIH HHS
ID : P01 AI116501
Pays : United States
Organisme : NIAID NIH HHS
ID : R21 AI132840
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK097075
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK122708
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK109574
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL119837
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK121330
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI145108
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL133900
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK122796
Pays : United States
Organisme : NIAAA NIH HHS
ID : U01 AA021723
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL065228
Pays : United States
Informations de copyright
Copyright © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.
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