Modeling SARS-CoV-2 viral kinetics and association with mortality in hospitalized patients from the French COVID cohort.

Aged Antibodies, Viral / blood COVID-19 / diagnosis Female France / epidemiology Hospitalization Humans Kinetics Male Models, Theoretical Nasopharynx / virology Prognosis Prospective Studies RNA, Viral / analysis Risk Factors SARS-CoV-2 / genetics Survival Rate Viral Load

SARS-CoV-2 mortality viral dynamics

Journal

Proceedings of the National Academy of Sciences of the United States of America

ISSN: 1091-6490

Titre abrégé: Proc Natl Acad Sci U S A

Pays: United States

ID NLM: 7505876

Informations de publication

Date de publication:
23 02 2021

Historique:

entrez: 4 2 2021

pubmed: 5 2 2021

medline: 16 2 2021

Statut: ppublish

Résumé

The characterization of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral kinetics in hospitalized patients and its association with mortality is unknown. We analyzed death and nasopharyngeal viral kinetics in 655 hospitalized patients from the prospective French COVID cohort. The model predicted a median peak viral load that coincided with symptom onset. Patients with age ≥65 y had a smaller loss rate of infected cells, leading to a delayed median time to viral clearance occurring 16 d after symptom onset as compared to 13 d in younger patients (

Identifiants

DOI: 10.1073/pnas.2017962118 PMID: 33536313 PMC: PMC7929555

pubmed: 33536313

pii: 2017962118

doi: 10.1073/pnas.2017962118

pmc: PMC7929555

pii:

doi:

Substances chimiques

Antibodies, Viral 0

RNA, Viral 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

Informations de copyright

Déclaration de conflit d'intérêts

Competing interest statement: J. Guedj has worked as a consultant for ROCHE Company.

Références

N Engl J Med. 2021 Feb 11;384(6):497-511

pubmed: 33264556

J Virol. 2003 Aug;77(15):8181-6

pubmed: 12857886

Chest. 2020 Nov;158(5):1876-1884

pubmed: 32569635

Lancet Infect Dis. 2020 Jun;20(6):656-657

pubmed: 32199493

Sci Adv. 2020 Nov 20;6(47):

pubmed: 33097472

N Engl J Med. 2020 Mar 19;382(12):1177-1179

pubmed: 32074444

Lancet Infect Dis. 2020 May;20(5):565-574

pubmed: 32213337

Lancet. 2020 Feb 15;395(10223):507-513

pubmed: 32007143

Cytokine. 2008 Sep;43(3):336-41

pubmed: 18694646

AAPS J. 2020 Feb 13;22(2):48

pubmed: 32060662

AAPS J. 2015 May;17(3):691-9

pubmed: 25739818

Cell. 2018 Jan 25;172(3):423-438.e25

pubmed: 29249360

Emerg Infect Dis. 2010 Aug;16(8):1265-72

pubmed: 20678321

Euro Surveill. 2020 Jan;25(3):

pubmed: 31992387

Lancet Infect Dis. 2020 Sep;20(9):1051-1060

pubmed: 32539986

Clin Infect Dis. 2020 Jun 30;:

pubmed: 32603425

Nat Med. 2020 Aug;26(8):1200-1204

pubmed: 32555424

N Engl J Med. 2021 Jan 21;384(3):229-237

pubmed: 33113295

Crit Care. 2020 Oct 16;24(1):610

pubmed: 33066801

JAMA. 2020 May 26;323(20):2052-2059

pubmed: 32320003

N Engl J Med. 2020 Aug 27;383(9):885-886

pubmed: 32530584

Growth Factors. 2004 Dec;22(4):243-51

pubmed: 15621727

Ann Intern Med. 2020 May 5;172(9):577-582

pubmed: 32150748

Lancet Infect Dis. 2014 Jan;14(1):8-9

pubmed: 24355025

Lancet Microbe. 2021 Jan;2(1):e13-e22

pubmed: 33521734

J Med Virol. 2021 Apr;93(4):2149-2159

pubmed: 33058220

Lancet. 2016 May 28;387(10034):2183-5

pubmed: 27145708

Nature. 2020 Aug;584(7821):430-436

pubmed: 32640463

Immunol Rev. 2018 Sep;285(1):97-112

pubmed: 30129197

Science. 1996 Mar 15;271(5255):1582-6

pubmed: 8599114

Wiley Interdiscip Rev Syst Biol Med. 2011 Jul-Aug;3(4):429-45

pubmed: 21197654

JAMA. 2020 Apr 21;323(15):1488-1494

pubmed: 32125362

JAMA. 2020 May 12;323(18):1775-1776

pubmed: 32203977

Lancet. 2020 Feb 15;395(10223):497-506

pubmed: 31986264

Math Biosci. 2020 Oct;328:108438

pubmed: 32771304

CPT Pharmacometrics Syst Pharmacol. 2020 Sep;9(9):509-514

pubmed: 32558354

Eur Respir J. 2020 Jul 16;56(1):

pubmed: 32430428

Immunity. 2006 Sep;25(3):373-81

pubmed: 16979569

Nat Med. 2020 May;26(5):672-675

pubmed: 32296168

Nature. 2020 Sep;585(7826):584-587

pubmed: 32698191

J Virol. 2019 Feb 19;93(5):

pubmed: 30541850

Clin Infect Dis. 2020 May 22;:

pubmed: 32442256

Eur J Clin Microbiol Infect Dis. 2020 Jun;39(6):1059-1061

pubmed: 32342252

PLoS Med. 2018 Mar 27;15(3):e1002535

pubmed: 29584730

J Infect. 2021 Feb 3;:

pubmed: 33545165

J Virol. 2006 Aug;80(15):7590-9

pubmed: 16840338

BMJ. 2020 Apr 21;369:m1443

pubmed: 32317267

Science. 1998 Oct 2;282(5386):103-7

pubmed: 9756471

Clin Pharmacol Ther. 2019 Oct;106(4):810-820

pubmed: 30985002

CPT Pharmacometrics Syst Pharmacol. 2020 May;9(5):258-271

pubmed: 32198838

Nat Med. 2020 May;26(5):681-687

pubmed: 32327758

Nat Commun. 2018 Oct 1;9(1):4013

pubmed: 30275474

BMJ. 2020 May 22;369:m1985

pubmed: 32444460