Regulatory genomic circuitry of human disease loci by integrative epigenomics.
Chromatin
/ genetics
Disease
/ genetics
Enhancer Elements, Genetic
/ genetics
Epigenesis, Genetic
/ genetics
Epigenomics
Female
Gene Regulatory Networks
/ genetics
Genetic Loci
/ genetics
Genome-Wide Association Study
Humans
Male
Multifactorial Inheritance
/ genetics
Organ Specificity
/ genetics
Reproducibility of Results
Journal
Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462
Informations de publication
Date de publication:
02 2021
02 2021
Historique:
received:
30
10
2019
accepted:
18
12
2020
pubmed:
5
2
2021
medline:
10
3
2021
entrez:
4
2
2021
Statut:
ppublish
Résumé
Annotating the molecular basis of human disease remains an unsolved challenge, as 93% of disease loci are non-coding and gene-regulatory annotations are highly incomplete
Identifiants
pubmed: 33536621
doi: 10.1038/s41586-020-03145-z
pii: 10.1038/s41586-020-03145-z
pmc: PMC7875769
doi:
Substances chimiques
Chromatin
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
300-307Subventions
Organisme : NIH HHS
ID : HG008155
Pays : United States
Organisme : NHGRI NIH HHS
ID : U41 HG007234
Pays : United States
Organisme : NIH HHS
ID : MH109978
Pays : United States
Organisme : NIH HHS
ID : MH119509
Pays : United States
Organisme : NHGRI NIH HHS
ID : U24 HG009446
Pays : United States
Organisme : NIH HHS
ID : GM087237
Pays : United States
Organisme : NIH HHS
ID : HG007234
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH109978
Pays : United States
Organisme : NIMH NIH HHS
ID : U01 MH119509
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG058002
Pays : United States
Organisme : NHGRI NIH HHS
ID : R01 HG008155
Pays : United States
Organisme : NHGRI NIH HHS
ID : R35 HG011317
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM113708
Pays : United States
Organisme : NHGRI NIH HHS
ID : U01 HG007610
Pays : United States
Organisme : NIH HHS
ID : HG009446
Pays : United States
Organisme : NIH HHS
ID : HG009088
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM087237
Pays : United States
Organisme : NIH HHS
ID : AG058002
Pays : United States
Organisme : NIH HHS
ID : HG007610
Pays : United States
Organisme : NIH HHS
ID : GM113708
Pays : United States
Organisme : NHGRI NIH HHS
ID : U01 HG009088
Pays : United States
Commentaires et corrections
Type : CommentIn
Type : CommentIn
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