Transient receptor potential channels in sensory mechanisms of the lower urinary tract.
Female
Humans
Lower Urinary Tract Symptoms
/ metabolism
Male
Muscle, Smooth
/ innervation
Prostate
/ metabolism
Sensation
/ physiology
TRPA1 Cation Channel
/ metabolism
TRPM Cation Channels
/ metabolism
TRPV Cation Channels
/ metabolism
Transient Receptor Potential Channels
/ metabolism
Urethra
/ metabolism
Urinary Bladder
/ innervation
Urothelium
/ innervation
Visceral Afferents
/ physiopathology
Journal
Nature reviews. Urology
ISSN: 1759-4820
Titre abrégé: Nat Rev Urol
Pays: England
ID NLM: 101500082
Informations de publication
Date de publication:
03 2021
03 2021
Historique:
accepted:
08
01
2021
pubmed:
5
2
2021
medline:
27
8
2021
entrez:
4
2
2021
Statut:
ppublish
Résumé
Disruptions to sensory pathways in the lower urinary tract commonly occur and can give rise to lower urinary tract symptoms (LUTS). The unmet clinical need for treatment of LUTS has stimulated research into the molecular mechanisms that underlie neuronal control of the bladder and transient receptor potential (TRP) channels have emerged as key regulators of the sensory processes that regulate bladder function. TRP channels function as molecular sensors in urothelial cells and afferent nerve fibres and can be considered the origin of bladder sensations. TRP channels in the lower urinary tract contribute to the generation of normal and abnormal bladder sensations through a variety of mechanisms, and have demonstrated potential as targets for the treatment of LUTS in functional disorders of the lower urinary tract.
Identifiants
pubmed: 33536636
doi: 10.1038/s41585-021-00428-6
pii: 10.1038/s41585-021-00428-6
doi:
Substances chimiques
TRPA1 Cation Channel
0
TRPM Cation Channels
0
TRPV Cation Channels
0
Transient Receptor Potential Channels
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
139-159Références
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