α-Particle-induced DNA damage tracks in peripheral blood mononuclear cells of [
53BP1
Biokinetics
DNA damage
Dosimetry
Nuclear medicine
Prostate cancer
[223Ra]RaCl2
α-Emitter
γ-H2AX
Journal
European journal of nuclear medicine and molecular imaging
ISSN: 1619-7089
Titre abrégé: Eur J Nucl Med Mol Imaging
Pays: Germany
ID NLM: 101140988
Informations de publication
Date de publication:
08 2021
08 2021
Historique:
received:
25
08
2020
accepted:
15
12
2020
pubmed:
5
2
2021
medline:
24
7
2021
entrez:
4
2
2021
Statut:
ppublish
Résumé
One therapy option for prostate cancer patients with bone metastases is the use of [ Multiple blood samples from nine prostate cancer patients were collected before and after administration of [ The absorbed doses to the blood were less than 6 mGy up to 4 h after administration and maximally 16 mGy in total. Up to 4 h after administration, the α-track frequency was significantly increased relative to baseline and correlated with the absorbed dose to the blood in the dose range < 3 mGy. In most of the late samples (24 h - 4 weeks after administration), the α-track frequency remained elevated. The γ-H2AX+53BP1 assay is a potent method for detection of α-particle-induced DNA damages during treatment with or after accidental incorporation of radionuclides even at low absorbed doses. It may serve as a biomarker discriminating α- from β-emitters based on damage geometry.
Identifiants
pubmed: 33537837
doi: 10.1007/s00259-020-05170-6
pii: 10.1007/s00259-020-05170-6
pmc: PMC8263441
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2761-2770Références
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