Design, Synthesis and Biological Activity of New Amides Derived from 3-Benzhydryl and 3-sec-Butyl-2,5-dioxo-pyrrolidin-1-yl-acetic Acid.
Acetic Acid
/ chemical synthesis
Amides
/ chemical synthesis
Analgesics
/ chemical synthesis
Antineoplastic Agents
/ chemical synthesis
Cell Proliferation
/ drug effects
Dose-Response Relationship, Drug
Drug Design
Drug Screening Assays, Antitumor
Formaldehyde
Hep G2 Cells
Humans
Molecular Structure
Pain
/ chemically induced
Seizures
/ chemically induced
Structure-Activity Relationship
Amides
anticonvulsant activity
antinociceptive activity
in vitro studies
in vivo studies
pyrrolidinedione
Journal
ChemMedChem
ISSN: 1860-7187
Titre abrégé: ChemMedChem
Pays: Germany
ID NLM: 101259013
Informations de publication
Date de publication:
18 05 2021
18 05 2021
Historique:
revised:
26
01
2021
received:
29
12
2020
pubmed:
5
2
2021
medline:
7
1
2022
entrez:
4
2
2021
Statut:
ppublish
Résumé
The aim of this study was to design and synthesize two new series of pyrrolidine-2,5-dione-acetamides with a benzhydryl or sec-butyl group at position 3 as potential anticonvulsants. Their anticonvulsant activity was evaluated in standard animal models of epilepsy: the maximal electroshock (MES), the 6 Hz, and the subcutaneous pentylenetetrazole (scPTZ) tests. The in vivo studies revealed the most potent anticonvulsant activity for 15 (3-(sec-butyl)-1-(2-(4-(3-trifluoromethylphenyl)piperazin-1-yl)-2-oxoethyl)pyrrolidine-2,5-dione), with ED
Identifiants
pubmed: 33539029
doi: 10.1002/cmdc.202001007
doi:
Substances chimiques
Amides
0
Analgesics
0
Antineoplastic Agents
0
Formaldehyde
1HG84L3525
Acetic Acid
Q40Q9N063P
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1619-1630Subventions
Organisme : Jagiellonian University Medical College
ID : K/ZDS/007864
Organisme : Jagiellonian University Medical College
ID : K/DSC/005295
Organisme : Jagiellonian University Medical College
ID : N42/DBS/000048
Organisme : National Science Centre, Poland
ID : 2017/25/B/NZ7/01048
Informations de copyright
© 2021 Wiley-VCH GmbH.
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