Clinical manifestations and outcomes of coronavirus disease-19 in heart transplant recipients: a multicentre case series with a systematic review and meta-analysis.
Adolescent
Adult
Aged
Aged, 80 and over
COVID-19
/ diagnosis
COVID-19 Testing
Female
Follow-Up Studies
France
Heart Transplantation
Humans
Male
Middle Aged
Postoperative Complications
/ diagnosis
Prognosis
Prospective Studies
Respiration, Artificial
/ statistics & numerical data
Risk Factors
Severity of Illness Index
Young Adult
COVID-19
heart transplant
immunosuppressive medication
Journal
Transplant international : official journal of the European Society for Organ Transplantation
ISSN: 1432-2277
Titre abrégé: Transpl Int
Pays: Switzerland
ID NLM: 8908516
Informations de publication
Date de publication:
04 2021
04 2021
Historique:
revised:
14
10
2020
received:
13
09
2020
accepted:
29
01
2021
pubmed:
5
2
2021
medline:
20
4
2021
entrez:
4
2
2021
Statut:
ppublish
Résumé
Available data on clinical presentation and mortality of coronavirus disease-2019 (COVID-19) in heart transplant (HT) recipients remain limited. We report a case series of laboratory-confirmed COVID-19 in 39 HT recipients from 3 French heart transplant centres (mean age 54.4 ± 14.8 years; 66.7% males). Hospital admission was required for 35 (89.7%) cases including 14/39 (35.9%) cases being admitted in intensive care unit. Immunosuppressive medications were reduced or discontinued in 74.4% of the patients. After a median follow-up of 54 (19-80) days, death and death or need for mechanical ventilation occurred in 25.6% and 33.3% of patients, respectively. Elevated C-reactive protein and lung involvement ≥50% on chest computed tomography (CT) at admission were associated with an increased risk of death or need for mechanical ventilation. Mortality rate from March to June in the entire 3-centre HT recipient cohort was 56% higher in 2020 compared to the time-matched 2019 cohort (2% vs. 1.28%, P = 0.15). In a meta-analysis including 4 studies, pre-existing diabetes mellitus (OR 3.60, 95% CI 1.43-9.06, I
Identifiants
pubmed: 33539616
doi: 10.1111/tri.13837
pmc: PMC8014589
doi:
Types de publication
Journal Article
Meta-Analysis
Multicenter Study
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
721-731Informations de copyright
© 2021 Steunstichting ESOT. Published by John Wiley & Sons Ltd.
Références
Nature. 2020 Mar;579(7798):270-273
pubmed: 32015507
Clin Transplant. 2020 Dec;34(12):e14089
pubmed: 32918761
Transplant Proc. 2020 Nov;52(9):2711-2714
pubmed: 32563584
JAMA Cardiol. 2020 Jul 1;5(7):811-818
pubmed: 32219356
Circulation. 2020 Jun 9;141(23):1930-1936
pubmed: 32243205
Am J Transplant. 2020 Nov;20(11):3008-3018
pubmed: 32780493
Am J Transplant. 2020 Oct;20(10):2876-2882
pubmed: 32412159
Am J Transplant. 2021 May;21(5):1825-1837
pubmed: 33098200
Circulation. 2020 May 19;141(20):1648-1655
pubmed: 32200663
Diabetes Metab Syndr. 2020 Jul - Aug;14(4):535-545
pubmed: 32408118
Arq Bras Cardiol. 2020 Sep;115(3):574-578
pubmed: 33027383
J Heart Lung Transplant. 2020 Jun;39(6):612-614
pubmed: 32503728
Am J Transplant. 2020 Oct;20(10):2916-2922
pubmed: 32378314
JACC Case Rep. 2020 Jul 15;2(9):1297-1301
pubmed: 32835271
Transpl Infect Dis. 2020 Oct;22(5):e13382
pubmed: 32583620
Transplantation. 2020 Nov;104(11):2208-2214
pubmed: 32496357
Am J Transplant. 2020 Jul;20(7):1885-1890
pubmed: 32330356
N Engl J Med. 2020 Jun 18;382(25):2441-2448
pubmed: 32356628
JACC Case Rep. 2020 Jul 15;2(9):1347-1350
pubmed: 32835277
Am J Transplant. 2020 Nov;20(11):3239-3245
pubmed: 32519406
Ann Intensive Care. 2019 Jan 25;9(1):17
pubmed: 30684052
Am J Transplant. 2020 Jul;20(7):1849-1858
pubmed: 32301155
Transplantation. 2021 Jan 1;105(1):128-137
pubmed: 32890139
N Engl J Med. 2020 Apr 30;382(18):1708-1720
pubmed: 32109013
Trop Med Infect Dis. 2020 May 15;5(2):
pubmed: 32429038
JAMA. 2020 May 26;323(20):2052-2059
pubmed: 32320003
J Heart Lung Transplant. 2020 Aug;39(8):855-857
pubmed: 32591314
J Card Fail. 2020 Jun;26(6):457-461
pubmed: 32417380
Eur J Cardiothorac Surg. 2020 Nov 1;58(5):899-906
pubmed: 33084868
Am J Transplant. 2020 Nov;20(11):3173-3181
pubmed: 32529737
J Heart Lung Transplant. 2020 Sep;39(9):983-985
pubmed: 32718694
Transpl Int. 2020 Sep;33(9):1099-1105
pubmed: 32460390
JAMA Cardiol. 2020 Oct 1;5(10):1165-1169
pubmed: 32402056
Research (Wash D C). 2020 Apr 19;2020:2402961
pubmed: 32377638
JACC Heart Fail. 2021 Jan;9(1):52-61
pubmed: 33309578
J Heart Lung Transplant. 2020 Aug;39(8):853-855
pubmed: 32586752
Mayo Clin Proc. 2008 Mar;83(3):304-8
pubmed: 18315996
Kidney Int. 2020 May;97(5):829-838
pubmed: 32247631
Clin Transplant. 2020 Nov;34(11):e14032
pubmed: 32621523
Transpl Infect Dis. 2020 Dec;22(6):e13367
pubmed: 32533615
Clin Transplant. 2020 Oct;34(10):e14027
pubmed: 32589760
J Heart Lung Transplant. 2020 May;39(5):496-497
pubmed: 32362394
Clin Transplant. 2020 Nov;34(11):e14070
pubmed: 32856335
Transpl Infect Dis. 2020 Dec;22(6):e13380
pubmed: 32573990
Clin Infect Dis. 2021 Dec 6;73(11):e4090-e4099
pubmed: 32766815
ESC Heart Fail. 2020 Oct;7(5):2003-2006
pubmed: 32648348
Clin Transplant. 2020 Dec;34(12):e14091
pubmed: 32940925
Am J Transplant. 2020 Jul;20(7):1911-1915
pubmed: 32315122
J Heart Lung Transplant. 2020 Sep;39(9):894-903
pubmed: 32891266
Diabetes Metab Syndr. 2020 May - Jun;14(3):247-250
pubmed: 32247212
Am J Transplant. 2020 Nov;20(11):3225-3233
pubmed: 32476258
Transplantation. 2007 Oct 15;84(7):851-6
pubmed: 17984837
Clin Res Cardiol. 2020 Dec;109(12):1531-1539
pubmed: 32783099
Transplantation. 2021 Jan 1;105(1):108-114
pubmed: 32826796
Int J Cardiol Heart Vasc. 2020 Jul 17;29:100596
pubmed: 32754630
Circulation. 2005 May 24;111(20):2605-10
pubmed: 15897343
J Heart Lung Transplant. 2020 Oct;39(10):1081-1088
pubmed: 32709482
Cell. 2020 Apr 16;181(2):271-280.e8
pubmed: 32142651
Clin Transplant. 2019 Sep;33(9):e13511
pubmed: 30817023
J Intensive Care Med. 2021 Apr;36(4):494-499
pubmed: 33034239
Rev Esp Cardiol (Engl Ed). 2020 Dec;73(12):1077-1080
pubmed: 32981843
Am J Transplant. 2020 Jul;20(7):1925-1929
pubmed: 32319218