Bio-guided isolation of leishmanicidal and trypanocidal constituents from Pituranthos battandieri aerial parts.

Apiaceae / chemistry Chemical Fractionation Leishmania mexicana / drug effects Plant Components, Aerial / chemistry Plant Extracts / chemistry Trypanocidal Agents / chemistry Trypanosoma cruzi / drug effects
Bioguided isolation Furanocoumarins Leishmanicidal Pituranthos battandieri Polyacetylenes Trypanocidal

Journal

Parasitology international
ISSN: 1873-0329
Titre abrégé: Parasitol Int
Pays: Netherlands
ID NLM: 9708549

Informations de publication

Date de publication:
Jun 2021
Historique:
received: 17 07 2019
revised: 22 01 2021
accepted: 29 01 2021
pubmed: 5 2 2021
medline: 31 8 2021
entrez: 4 2 2021
Statut: ppublish

Résumé

Protozoan pathogens that cause neglected tropical diseases are a major public health concern in tropical and developing countries. In the course of our ongoing search for new lead compounds as potential antiprotozoal agents, this study aims to perform a bio-guided fractionation of Pituranthos battandieri, using an in vitro assay against Leishmania amazonensis and Trypanosoma cruzi. Two known polyacetylenes, (-)-panaxydiol (1) and (-)-falcarindiol (2) were identified from the ethanolic extract of the aerial parts of P. battandieri as the main bioactive constituents. Compounds 1 and 2 showed similar potency (IC

Identifiants

DOI: 10.1016/j.parint.2021.102300 PMID: 33540121
pubmed: 33540121
pii: S1383-5769(21)00019-2
doi: 10.1016/j.parint.2021.102300
pii:
doi:

Substances chimiques

Plant Extracts 0
Trypanocidal Agents 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

102300

Informations de copyright

Copyright © 2021 Elsevier B.V. All rights reserved.

Auteurs

Imad Mennai (I)

Unité de Recherche Valorisation des Ressources Naturelles, Molécules Bioactives et Analyses Physicochimiques et Biologiques, Université Frères Mentouri, Constantine 1, Route d'Ain El Bey, 25000 Constantine, Algeria.

Ines Sifaoui (I)

University Institute of Tropical Diseases and Public Heath, University of La Laguna, Avenida Astrofísico Francisco Sánchez s/n, Campus de Anchieta, Tenerife, Canary Islands, Spain.

Chahrazed Esseid (C)

Unité de Recherche Valorisation des Ressources Naturelles, Molécules Bioactives et Analyses Physicochimiques et Biologiques, Université Frères Mentouri, Constantine 1, Route d'Ain El Bey, 25000 Constantine, Algeria.

Atteneri López-Arencibia (A)

University Institute of Tropical Diseases and Public Heath, University of La Laguna, Avenida Astrofísico Francisco Sánchez s/n, Campus de Anchieta, Tenerife, Canary Islands, Spain.

María Reyes-Batlle (M)

University Institute of Tropical Diseases and Public Heath, University of La Laguna, Avenida Astrofísico Francisco Sánchez s/n, Campus de Anchieta, Tenerife, Canary Islands, Spain.

Fadila Benayache (F)

Unité de Recherche Valorisation des Ressources Naturelles, Molécules Bioactives et Analyses Physicochimiques et Biologiques, Université Frères Mentouri, Constantine 1, Route d'Ain El Bey, 25000 Constantine, Algeria.

Samir Benayache (S)

Unité de Recherche Valorisation des Ressources Naturelles, Molécules Bioactives et Analyses Physicochimiques et Biologiques, Université Frères Mentouri, Constantine 1, Route d'Ain El Bey, 25000 Constantine, Algeria.

Isabel L Bazzocchi (IL)

Instituto Universitario de Bio-Orgánica Antonio González, Departamento de Química Orgánica, Universidad de La Laguna, Avenida Astrofísico Francisco Sánchez 2, 38206 La Laguna, Tenerife, Canary Islands, Spain.

Jacob Lorenzo-Morales (J)

University Institute of Tropical Diseases and Public Heath, University of La Laguna, Avenida Astrofísico Francisco Sánchez s/n, Campus de Anchieta, Tenerife, Canary Islands, Spain.

José E Piñero (JE)

University Institute of Tropical Diseases and Public Heath, University of La Laguna, Avenida Astrofísico Francisco Sánchez s/n, Campus de Anchieta, Tenerife, Canary Islands, Spain.

Ignacio A Jiménez (IA)

Instituto Universitario de Bio-Orgánica Antonio González, Departamento de Química Orgánica, Universidad de La Laguna, Avenida Astrofísico Francisco Sánchez 2, 38206 La Laguna, Tenerife, Canary Islands, Spain. Electronic address: ignadiaz@ull.edu.es.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Viridiplantae › Streptophyta › Embryophyta › Tracheobionta › Magnoliopsida › Apiaceae › Bio-guided isolation of leishmanicidal and...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Fractionnement chimique › Bio-guided isolation of leishmanicidal and...
questionsmedicales.fr › Eucaryotes › Euglénozoaires › Kinetoplastida › Trypanosomatina › Leishmania › Leishmania mexicana › Bio-guided isolation of leishmanicidal and...
questionsmedicales.fr › Structures de plante › Parties aériennes de plante › Bio-guided isolation of leishmanicidal and...
questionsmedicales.fr › Préparations pharmaceutiques › Extraits de plantes › Bio-guided isolation of leishmanicidal and...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antiparasitaires › Antiprotozoaires › Trypanocides › Bio-guided isolation of leishmanicidal and...
questionsmedicales.fr › Eucaryotes › Euglénozoaires › Kinetoplastida › Trypanosomatina › Trypanosoma › Trypanosoma cruzi › Bio-guided isolation of leishmanicidal and...