Neuroimmune Response Mediated by Cytokines in Natural Scrapie after Chronic Dexamethasone Treatment.
Animals
Anti-Inflammatory Agents
/ pharmacology
Astrocytes
/ metabolism
Brain
/ metabolism
Cytokines
/ metabolism
Dexamethasone
/ administration & dosage
Gene Expression Profiling
Immunohistochemistry
Inflammation
Interleukin-1
/ metabolism
Neuroglia
/ metabolism
Prion Proteins
/ metabolism
Prions
/ metabolism
Reverse Transcriptase Polymerase Chain Reaction
Scrapie
/ drug therapy
Sheep
cytokines
dexamethasone
neuroinflammation
prion diseases
scrapie
Journal
Biomolecules
ISSN: 2218-273X
Titre abrégé: Biomolecules
Pays: Switzerland
ID NLM: 101596414
Informations de publication
Date de publication:
02 02 2021
02 02 2021
Historique:
received:
14
01
2021
accepted:
27
01
2021
entrez:
5
2
2021
pubmed:
6
2
2021
medline:
20
7
2021
Statut:
epublish
Résumé
The actual role of prion protein-induced glial activation and subsequent cytokine secretion during prion diseases is still incompletely understood. The overall aim of this study is to assess the effect of an anti-inflammatory treatment with dexamethasone on different cytokines released by neuroglial cells that are potentially related to neuroinflammation in natural scrapie. This study emphasizes the complex interactions existent among several pleiotropic neuromodulator peptides and provides a global approach to clarify neuroinflammatory processes in prion diseases. Additionally, an impairment of communication between microglial and astroglial populations mediated by cytokines, mainly IL-1, is suggested. The main novelty of this study is that it is the first one assessing in situ neuroinflammatory activity in relation to chronic anti-inflammatory therapy, gaining relevance because it is based on a natural model. The cytokine profile data would suggest the activation of some neurotoxicity-associated route. Consequently, targeting such a pathway might be a new approach to modify the damaging effects of neuroinflammation.
Identifiants
pubmed: 33540568
pii: biom11020204
doi: 10.3390/biom11020204
pmc: PMC7912810
pii:
doi:
Substances chimiques
Anti-Inflammatory Agents
0
Cytokines
0
Interleukin-1
0
Prion Proteins
0
Prions
0
Dexamethasone
7S5I7G3JQL
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : European Regional Development Fund
ID : POCTEFA EFA 148/16 REDPRION
Organisme : Ministerio de Educación, Cultura y Deporte
ID : FPU Nº 15/03524
Références
Vet Res Commun. 2007 Aug;31 Suppl 1:265-7
pubmed: 17682891
Curr Pharm Des. 2011 Nov;17(34):3781-5
pubmed: 22103849
Immunol Today. 1991 Nov;12(11):422
pubmed: 1786076
J Clin Invest. 1998 Jan 15;101(2):311-20
pubmed: 9435302
J Virol. 1994 Apr;68(4):2383-7
pubmed: 8139024
Methods Find Exp Clin Pharmacol. 1994 Jan-Feb;16(1):29-35
pubmed: 8164471
Pflugers Arch. 2019 Oct;471(10):1247-1261
pubmed: 31520182
Histol Histopathol. 2010 Aug;25(8):1025-38
pubmed: 20552553
Neuropathol Appl Neurobiol. 2002 Apr;28(2):107-19
pubmed: 11972797
Neuron. 2015 Feb 4;85(3):534-48
pubmed: 25619654
Endocr Rev. 2003 Aug;24(4):488-522
pubmed: 12920152
Neurobiol Aging. 2000 May-Jun;21(3):383-421
pubmed: 10858586
J Leukoc Biol. 2002 Aug;72(2):233-8
pubmed: 12149413
Prog Neurobiol. 2003 Aug;70(6):473-507
pubmed: 14568361
Brain Behav Immun. 2009 Jul;23(5):573-9
pubmed: 19258032
Brain Res. 1994 Aug 22;654(2):200-6
pubmed: 7987669
Neuroscience. 2001;105(1):1-5
pubmed: 11483295
J Immunol. 2000 May 1;164(9):4878-82
pubmed: 10779797
Neuron. 2009 Oct 15;64(1):33-9
pubmed: 19840546
J Neuroimmunol. 1999 Jan 1;93(1-2):194-202
pubmed: 10378883
Nature. 2017 Jan 26;541(7638):481-487
pubmed: 28099414
Neurochem Res. 2012 Nov;37(11):2326-38
pubmed: 22476701
Brain Res. 2002 Jan 25;925(2):195-203
pubmed: 11792368
Neurosci Lett. 1988 Nov 22;94(1-2):17-22
pubmed: 3266526
J Neurosci. 2005 Oct 5;25(40):9275-84
pubmed: 16207887
Brain Res. 1993 Dec 3;629(2):245-52
pubmed: 7509248
Curr Opin Neurol. 2002 Jun;15(3):349-54
pubmed: 12045736
Inflammopharmacology. 2009 Feb;17(1):15-22
pubmed: 19139829
Arthritis Res Ther. 2006;8 Suppl 2:S3
pubmed: 16899107
Int J Dev Neurosci. 2006 Apr-May;24(2-3):167-76
pubmed: 16472958
Endocr Rev. 1984 Winter;5(1):25-44
pubmed: 6368214
Glia. 2015 Aug;63(8):1394-405
pubmed: 26010551
J Immunol. 2008 May 1;180(9):5771-7
pubmed: 18424693
Front Aging Neurosci. 2017 Jun 23;9:207
pubmed: 28690540
Front Cell Neurosci. 2014 Apr 22;8:112
pubmed: 24795567
Immunity. 2015 Jul 21;43(1):92-106
pubmed: 26163371
Blood. 1996 Mar 15;87(6):2095-147
pubmed: 8630372
J Gen Virol. 2008 Jul;89(Pt 7):1777-1788
pubmed: 18559949
Trends Immunol. 2016 Oct;37(10):668-679
pubmed: 27616557
Brain Res. 1996 Apr 9;715(1-2):9-16
pubmed: 8739617
Nat Immunol. 2003 Jun;4(6):551-6
pubmed: 12754507
Mol Cell Neurosci. 1996 May;7(5):354-70
pubmed: 8812062
Microbiol Spectr. 2016 Jun;4(3):
pubmed: 27337461
Brain. 2017 Mar 1;140(3):826-842
pubmed: 28003243
BMC Vet Res. 2006 Dec 27;2:37
pubmed: 17192191
Acta Neuropathol. 2016 Mar;131(3):323-45
pubmed: 26671410
Neuron. 2015 Feb 4;85(3):519-33
pubmed: 25619653
Cell Tissue Res. 2012 Oct;350(1):127-34
pubmed: 22821398
J Neurol Neurosurg Spine. 2016;1(1):
pubmed: 28127589
Neuroreport. 1999 Mar 17;10(4):723-9
pubmed: 10208538
Mol Cell Endocrinol. 1992 Dec;90(1):C1-4
pubmed: 1301388
Brain Behav Immun. 2016 Feb;52:58-70
pubmed: 26434621
Scand J Rheumatol. 2007 May-Jun;36(3):165-6
pubmed: 17657667
Proc Natl Acad Sci U S A. 1993 Nov 1;90(21):10061-5
pubmed: 7694279
Brain Pathol. 2018 Mar;28(2):240-263
pubmed: 28268246
Proc Natl Acad Sci U S A. 1999 Jul 20;96(15):8721-6
pubmed: 10411942
J Biol Chem. 1995 Apr 21;270(16):9558-63
pubmed: 7721885
J Neurosci Res. 1999 Nov 15;58(4):593-8
pubmed: 10533051
J Neuropathol Exp Neurol. 2001 Feb;60(2):173-82
pubmed: 11273005
Neuroscience. 1991;43(1):21-30
pubmed: 1833666
Cell Tissue Res. 2014 Oct;358(1):57-63
pubmed: 24931403
J Gen Virol. 2003 Sep;84(Pt 9):2605-2611
pubmed: 12917482
Neuroscience. 2006;137(1):301-8
pubmed: 16289587
J Nucl Med. 2015 May;56(5):701-6
pubmed: 25766898
Neuron. 2014 Jan 22;81(2):229-48
pubmed: 24462092
J Virol. 2015 Feb;89(4):2388-404
pubmed: 25505076
Brain Behav Immun. 2008 Jan;22(1):105-13
pubmed: 17890050
Neurobiol Aging. 2009 Dec;30(12):1924-35
pubmed: 18375019
J Virol. 2000 Apr;74(7):3338-44
pubmed: 10708451
J Neuroinflammation. 2016 Nov 24;13(1):297
pubmed: 27881137
J Neurochem. 2016 Oct;139 Suppl 2:136-153
pubmed: 26990767
Mol Chem Neuropathol. 1995 Feb-Apr;24(2-3):223-5
pubmed: 7632323
Brain. 2016 Apr;139(Pt 4):1237-51
pubmed: 26912648
J Neurosci Res. 2005 Aug 1;81(3):302-13
pubmed: 15954124
J Neurochem. 2003 Feb;84(4):705-16
pubmed: 12562515
Mech Ageing Dev. 2019 Dec;184:111176
pubmed: 31689427
Science. 2016 Aug 19;353(6301):777-83
pubmed: 27540165
J Immunol. 1990 Jan 15;144(2):499-505
pubmed: 2104896
J Physiol. 2006 Jun 1;573(Pt 2):413-25
pubmed: 16543270
Neurochem Res. 2003 Feb;28(2):307-18
pubmed: 12608703
Dev Comp Immunol. 2004 May 3;28(5):487-97
pubmed: 15062645
Int J Mol Sci. 2020 May 02;21(9):
pubmed: 32370224
Proc Natl Acad Sci U S A. 1996 Sep 3;93(18):9754-8
pubmed: 8790403
Int J Dev Neurosci. 2004 Nov;22(7):497-505
pubmed: 15465279
J Virol. 2004 Dec;78(24):13697-707
pubmed: 15564479
Lab Invest. 1992 Feb;66(2):223-30
pubmed: 1370967
Brain Res. 1997 Apr 18;754(1-2):171-80
pubmed: 9134973
Proc Natl Acad Sci U S A. 2002 Jan 22;99(2):919-24
pubmed: 11792852
Hum Pathol. 1995 Aug;26(8):816-23
pubmed: 7635444
Mol Cell Neurosci. 2000 Sep;16(3):221-32
pubmed: 10995549
Am J Pathol. 2004 Aug;165(2):671-8
pubmed: 15277240
J Virol. 2009 Nov;83(21):11244-53
pubmed: 19710140
Nat Rev Neurosci. 2001 Oct;2(10):734-44
pubmed: 11584311
Biochem Biophys Res Commun. 2003 Oct 24;310(3):725-9
pubmed: 14550262
Neuroscience. 1999 Mar;89(1):127-36
pubmed: 10051222
Cell Death Dis. 2011 Jun 02;2:e167
pubmed: 21633390
Neuropathol Appl Neurobiol. 2013 Feb;39(1):3-18
pubmed: 23252647
J Virol. 2002 May;76(10):5131-9
pubmed: 11967328
Front Aging Neurosci. 2014 Aug 04;6:198
pubmed: 25136317
Mamm Genome. 2007 Jan;18(1):53-63
pubmed: 17242860
Immunol Today. 1997 Sep;18(9):428-32
pubmed: 9293158
Medicine (Baltimore). 2018 Apr;97(15):e0320
pubmed: 29642165
J Virol. 2015 Dec 30;90(6):3003-17
pubmed: 26719249