18F-FDG PET cannot predict expression of clinically relevant histopathological biomarkers in head and neck squamous cell carcinoma: a meta-analysis.
Apoptosis
Apoptosis Regulatory Proteins
/ analysis
Biomarkers, Tumor
Cell Proliferation
ErbB Receptors
/ analysis
Fluorodeoxyglucose F18
Genes, p53
Glucose Transporter Type 1
/ analysis
Head and Neck Neoplasms
/ diagnostic imaging
Humans
Ki-67 Antigen
/ analysis
Microcirculation
Positron-Emission Tomography
/ methods
Repressor Proteins
/ analysis
Squamous Cell Carcinoma of Head and Neck
/ diagnostic imaging
FDG PET
GLUT
KI 67
epidermal growth factor receptor
hypoxia-inducible factor-1α
p53
vascular endothelial growth factor
Journal
Acta radiologica (Stockholm, Sweden : 1987)
ISSN: 1600-0455
Titre abrégé: Acta Radiol
Pays: England
ID NLM: 8706123
Informations de publication
Date de publication:
Feb 2022
Feb 2022
Historique:
pubmed:
6
2
2021
medline:
8
1
2022
entrez:
5
2
2021
Statut:
ppublish
Résumé
Head and neck squamous cell carcinoma (HNSCC) is a common cancer. Positron emission tomography (PET) with 18F-fluorodeoxyglucose (18F-FDG) is a widely used imaging modality in HNSCC. To provide evident data about associations between 18F-FDG PET and histopathology in HNSCC. The MEDLINE database was screened for associations between maximum standard uptake values (SUV The following correlations were calculated: KI 67: 12 studies (345 patients), pooled correlation coefficient (PCC): 0.23 (95% confidence interval [CI] 0.06-0.40); hypoxia-inducible factor-1α: eight studies (240 patients), PCC: 0.24 (95% CI 0.06-0.42); microvessel density: three studies (64 patients), PCC: 0.33 (95% CI 0.02-0.65); vascular endothelial growth factor: two studies (59 cases), PCC: 0.27 (95% CI 0.02-0.51); tumor suppressor protein p53: four studies (159 patients), PCC: 0.05 (95% CI -0.41 to 0.51); epidermal growth factor receptor: two studies (124 patients), PCC: 0.21 (95% CI 0.05-0.37); tumor cell count: three studies (67 patients), PCC: 0.18 (95% CI -0.06 to 0.42); tumor cell apoptosis: two studies (40 patients), PCC: 0.07 (95% CI = -0.85 to 0.99); B-cell lymphoma-2 protein: two studies (118 patients); PCC: 0.04 (95% CI -0.65 to 0.74); glucose-transporter 1: 10 studies (317 patients), PCC: 0.20 (95% CI 0.10-0.30). SUV
Sections du résumé
BACKGROUND
BACKGROUND
Head and neck squamous cell carcinoma (HNSCC) is a common cancer. Positron emission tomography (PET) with 18F-fluorodeoxyglucose (18F-FDG) is a widely used imaging modality in HNSCC.
PURPOSE
OBJECTIVE
To provide evident data about associations between 18F-FDG PET and histopathology in HNSCC.
MATERIAL AND METHODS
METHODS
The MEDLINE database was screened for associations between maximum standard uptake values (SUV
RESULTS
RESULTS
The following correlations were calculated: KI 67: 12 studies (345 patients), pooled correlation coefficient (PCC): 0.23 (95% confidence interval [CI] 0.06-0.40); hypoxia-inducible factor-1α: eight studies (240 patients), PCC: 0.24 (95% CI 0.06-0.42); microvessel density: three studies (64 patients), PCC: 0.33 (95% CI 0.02-0.65); vascular endothelial growth factor: two studies (59 cases), PCC: 0.27 (95% CI 0.02-0.51); tumor suppressor protein p53: four studies (159 patients), PCC: 0.05 (95% CI -0.41 to 0.51); epidermal growth factor receptor: two studies (124 patients), PCC: 0.21 (95% CI 0.05-0.37); tumor cell count: three studies (67 patients), PCC: 0.18 (95% CI -0.06 to 0.42); tumor cell apoptosis: two studies (40 patients), PCC: 0.07 (95% CI = -0.85 to 0.99); B-cell lymphoma-2 protein: two studies (118 patients); PCC: 0.04 (95% CI -0.65 to 0.74); glucose-transporter 1: 10 studies (317 patients), PCC: 0.20 (95% CI 0.10-0.30).
CONCLUSION
CONCLUSIONS
SUV
Identifiants
pubmed: 33541089
doi: 10.1177/0284185121988973
doi:
Substances chimiques
Apoptosis Regulatory Proteins
0
Biomarkers, Tumor
0
Glucose Transporter Type 1
0
HIF3A protein, human
0
Ki-67 Antigen
0
Repressor Proteins
0
Fluorodeoxyglucose F18
0Z5B2CJX4D
EGFR protein, human
EC 2.7.10.1
ErbB Receptors
EC 2.7.10.1
Types de publication
Journal Article
Meta-Analysis
Langues
eng
Sous-ensembles de citation
IM